1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI)
- CAS No.
- 178747-83-6
- Chemical Name:
- 1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI)
- Synonyms
- 4-fluorobenzo[d]isoxazol-3-ol;4-fluoro-1,2-benzoxazol-3-one;4-Fluorobenzisoxazol-3(2H)-one;4-Fluorobenzo[d]isoxazol-3(2H)-one;4-Fluoro-1,2-benzisoxazol-3(2H)-one;1,2-Benzisoxazol-3(2H)-one, 4-fluoro-;1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI)
- CBNumber:
- CB11272287
- Molecular Formula:
- C7H4FNO2
- Molecular Weight:
- 153.11
- MDL Number:
- MFCD18804910
- MOL File:
- 178747-83-6.mol
1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI) price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC201177 | 4-Fluorobenzo[d]isoxazol-3(2H)-one >98% | 178747-83-6 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC201177 | 4-Fluorobenzo[d]isoxazol-3(2H)-one >98% | 178747-83-6 | 250mg | $25 | 2026-06-04 | Buy |
| Apolloscientific | PC201177 | 4-Fluorobenzo[d]isoxazol-3(2H)-one >98% | 178747-83-6 | 1g | $93 | 2026-06-04 | Buy |
| Apolloscientific | PC201177 | 4-Fluorobenzo[d]isoxazol-3(2H)-one >98% | 178747-83-6 | 5g | $436 | 2026-06-04 | Buy |
| Apolloscientific | PC201177 | 4-Fluorobenzo[d]isoxazol-3(2H)-one >98% | 178747-83-6 | 25g | $1990 | 2026-06-04 | Buy |
1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI) Chemical Properties,Uses,Production
Synthesis
855996-64-4
178747-83-6
The general procedure for the synthesis of 4-fluorophenyl[d]isoxazol-3-one from 2-fluoro-N,6-dihydroxybenzamide is as follows: 1. Add tetrahydrofuran (2.23L) and 1,1'-carbonyl diimidazole (0.910Kg, 5.64mol) to a 20L jacketed reactor and mix with stirring at 20°C. 2. A solution of 2-fluoro-N,6-dihydroxybenzamide (744 g, 4.34 mol) in tetrahydrofuran (4.45 L) was slowly added to the reactor, the temperature was controlled to be lower than 30 °C, and stirring was continued at 25 °C for 30 h. The reaction was carried out at 25 °C with continuous stirring. Gas release was observed during the reaction. 3. The reaction mixture was warmed up to 60°C within 30 minutes and stirring was continued for 6 hours. 4. Upon completion of the reaction, the reactor was cooled to 20 °C and the pH was adjusted to 1 by adding 1N aqueous HCl (7.48 L) within 15 min. 5. set the jacket temperature to 35°C and concentrated the reaction mixture under vacuum to remove about 6.68 L of tetrahydrofuran. 6. The reactor was cooled to 15 °C and stirred for 1 h. A white slurry was obtained by filtration. The filter cake was washed with water (3.71 L) and dried in a vacuum oven at 40°C for 12 hours. 7. The target product 4-fluorobenzo[d]isoxazol-3-ol (597 g, 3.90 mol) was finally isolated in 90% yield. Product characterization data: 1H NMR (400MHz, CD3OD) δ ppm 4.93 (b, 1H), 6.95 (dd, J = 10.1, 8.6, 1H), (d, J = 8.6, 1H), 7.52-7.57 (m, 1H); LRMS 154.029 (m + 1).
References
[1] Patent: WO2011/101774, 2011, A1. Location in patent: Page/Page column 25; 27
1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
1,2-Benzisoxazol-3(2H)-one,4-fluoro-(9CI) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Ji Ping Jia Chemical Co., Ltd. | 18622448868 | jpjchem@163.com | China | 489 | 62 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
| Shanghai YuLue Chemical Co., Ltd. | 021-60345187 13671753212 | lzz841106@aliyun.com | China | 10244 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4967 | 58 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 7994 | 58 |
| Allfluoro Pharmaceutical Company Limited | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11380 | 58 |
