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ChemicalBook >> CAS DataBase List >>10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)-

10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)-

10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)- Structure
10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)- structure
CAS No.
2857037-69-3
Chemical Name:
10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)-
Synonyms
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT;10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)-
CBNumber:
CB112971719
Molecular Formula:
C26H23N3O6
Molecular Weight:
473.48
MDL Number:
MOL File:
2857037-69-3.mol
Last updated:2025-04-17 18:22:24
Request For Quotation

10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)- Properties

Boiling point 850.5±65.0 °C(Predicted)
Density 1.65±0.1 g/cm3(Predicted)
pka 11.17±0.20(Predicted)
form Solid
color Off-white to light yellow

10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)- Chemical Properties,Uses,Production

Uses

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) is a topoisomerase I inhibitor，which can be delivered to cells through conjugated antibody targeting，and has good ADC activity in vivo and in vitro[1].

References

[1] Andrew C. Phillips, et al. Anti-c-met antibody drug conjugates.WO2022232834.

10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)- Preparation Products And Raw materials

Raw materials

Preparation Products

10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Tekanbio Pharm-Tech Co., Ltd. 021-50896099 18017206244 sales@tekanbio.com China 107 58
Anhui JYHX CO., LTD. 0551-68788198 13295518198 wangyanan@ahjyhx.com China 1759 58
Hubei Rhema Reference Materials Technology Co., Ltd. 15787875101 645977340@qq.com China 9995 58
Supplier Advantage
Shanghai Tekanbio Pharm-Tech Co., Ltd. 58
Anhui JYHX CO., LTD. 58
Hubei Rhema Reference Materials Technology Co., Ltd. 58
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT 10H-1,3-Dioxolo[4,5-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione, 14-(3-aminobicyclo[1.1.1]pent-1-yl)-7-ethyl-7-hydroxy-, (7S)- 2857037-69-3