columbamine
- CAS No.
- 3621-36-1
- Chemical Name:
- columbamine
- Synonyms
- Columbamin;Dehydroisocorypalmine;Columbamine (Columbamin;Columbamine, 10 mM in DMSO;Inhibitor,Columbamine,inhibit;5,6-Dihydro-3,9,10-trimethoxydibenzo[a,g]quinolizinium-2-ol;5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium;Dibenzo[a,g]quinolizinium,5,6-dihydro-2-hydroxy-3,9,10-trimethoxy-;3,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2-ol;2-Hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium
- CBNumber:
- CB11321390
- Molecular Formula:
- [C20H20NO4]+.
- Molecular Weight:
- 0
- MDL Number:
- MFCD01546522
- MOL File:
- 3621-36-1.mol
- MSDS File:
- SDS
| Melting point | 280-282℃ (methanol ) |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO: soluble |
| form | Powder |
| color | Light yellow to orange |
| FDA UNII | 7T4808FEJW |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H402 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
columbamine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FC74185 | Columbamine | 3621-36-1 | 5mg | $92 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC74185 | Columbamine | 3621-36-1 | 10mg | $160 | 2021-12-16 | Buy |
| AK Scientific | 9161AF | Columbamine | 3621-36-1 | 1mg | $174 | 2021-12-16 | Buy |
| ChemScene | CS-4254 | Columbamine 98.38% | 3621-36-1 | 5mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-4254 | Columbamine 98.38% | 3621-36-1 | 10mg | $288 | 2021-12-16 | Buy |
columbamine Chemical Properties,Uses,Production
Chemical Properties
Orange-yellow crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tomato rhizomes, leaves, green fruits, high in content, and low in mature fruits.
Uses
Columbamine has antibacterial, anti-inflammatory, antihistamine, cardiotonic, anticancer effects.
Definition
ChEBI: Columbamine is a berberine alkaloid and an organic heterotetracyclic compound.
Biological Activity
Columbamine is a quaternary isoquinoline alkaloid extracted from plants.
in vivo
Columbamine (5-20 mg/kg; 23 days) significantly decreases the tumor volumes in a dose-dependent manner in HCT116 xenograft mice model[4].
| Animal Model: | Six-weeks-old male BALB/c nude mice (subcutaneously injected with HCT116 and control cells on the opposite flanks of the same mouse)[4] |
| Dosage: | 5, 10, 20 mg/kg |
| Administration: | Administered to experimental mice for 23 days |
| Result: | Decreased the tumor volumes in a dose-dependent manner. |
IC 50
CYP3A4: 30.6 μM (IC50)
columbamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 953 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10244 | 58 |
View Lastest Price from columbamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-01 | Columbamine
3621-36-1
|
US $43.00-137.00 / mg | 99.16% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Columbamine
3621-36-1
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2020-01-13 | columbamine
3621-36-1
|
US $5.50 / KG | 1KG | 98%min | 1kg-100kg | Career Henan Chemical Co |
-
- Columbamine
3621-36-1
- US $43.00-137.00 / mg
- 99.16%
- TargetMol Chemicals Inc.
-
- Columbamine
3621-36-1
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- columbamine
3621-36-1
- US $5.50 / KG
- 98%min
- Career Henan Chemical Co
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