Nedosiran Sodium
- CAS No.
- 2247026-22-6
- Chemical Name:
- Nedosiran Sodium
- Synonyms
- Nedosiran Sodium;Hexanamide, N-[2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]- (ACI)
- CBNumber:
- CB113379963
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Nedosiran sodium 92.35% | CS-0781819 | 1mg | $313 |
| Nedosiran sodium 92.35% | CS-0781819 | 5mg | $756 |
| Nedosiran sodium 92.35% | CS-0781819 | 10mg | $1192 |
| Nedosiran sodium 92.35% | CS-0781819 | 50mg | $2979 |
| Nedosiran sodium 92.35% | CS-0781819 | 100mg | $4469 |
| form | Solid |
|---|---|
| color | White to off-white |
| FDA UNII | EGR9KYM536 |
Nedosiran Sodium price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0781819 | Nedosiran sodium 92.35% | 2247026-22-6 | 1mg | $313 | 2026-06-04 | Buy |
| ChemScene | CS-0781819 | Nedosiran sodium 92.35% | 2247026-22-6 | 5mg | $756 | 2026-06-04 | Buy |
| ChemScene | CS-0781819 | Nedosiran sodium 92.35% | 2247026-22-6 | 10mg | $1192 | 2026-06-04 | Buy |
| ChemScene | CS-0781819 | Nedosiran sodium 92.35% | 2247026-22-6 | 50mg | $2979 | 2026-06-04 | Buy |
| ChemScene | CS-0781819 | Nedosiran sodium 92.35% | 2247026-22-6 | 100mg | $4469 | 2026-06-04 | Buy |
Nedosiran Sodium Chemical Properties,Uses,Production
Uses
Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate[1][2][3].
in vivo
Nedosiran sodium is a RNAi therapy for primary hyperoxaluria that selectively reduce hepatic expression of lactate dehydrogenase[3].
Nedosiran sodium specially inhibits hepatic expression of lactate dehydrogenase (LDHA)[3].
Nedosiran sodium is a double-strand siRNA molecule that is conjugated with GalNAc, which takes advantage of the aforementioned unique asialoglycoprotein receptor (ASGPR) delivery system in the liver. Nedosiran sodium is administered by monthly subcutaneous injection. Nedosiran sodium decreases plasma oxalate in animal models[3].
References
[1] Kevin Shee, et al. Nedosiran Dramatically Reduces Serum Oxalate in Dialysis-Dependent Primary Hyperoxaluria 1: A Compassionate Use Case Report. Urology.2021 Oct;156:e147-e149. DOI:10.1016/j.urology.2021.03.014
[2] Gema Ariceta, et al. Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria. Kidney Int Rep.2021 Feb 3;6(4):1088-1098. DOI:10.1016/j.ekir.2021.01.029
[3] Thomas A Forbes, et al. Therapeutic RNA interference: A novel approach to the treatment of primary hyperoxaluria. Br J Clin Pharmacol.2021 May 22. DOI:10.1111/bcp.14925
Nedosiran Sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Nedosiran Sodium Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +86-0086-13720134139 | orders@jknbiochem.com | China | 5215 | 58 |
| Chongqing jooe co., ltd | +86-15223382610 | info@jooe.com | China | 15967 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7234 | 58 |
| Olix ( Hubei) Pharmaceutical Technology Co., Ltd | 17316404525 17316404525 | 209533805@qq.com | China | 9771 | 58 |
| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 9988 | 58 |
