2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
- CAS No.
- 194085-75-1
- Chemical Name:
- 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE
- Synonyms
- YKP 509;RWJ 333369;Carisbamate;JNJ 10234094;(S)-Carisbamate;CarisbaMate (RWJ-333369);2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE;[(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate;1,2-ETHANEDIOL,1-(2-CHLOROPHENYL)-, 2-CARBAMATE, (S)-;1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbaMate, (1S)-
- CBNumber:
- CB11474577
- Molecular Formula:
- C813CH8D2Cl15NO3
- Molecular Weight:
- 215.63
- MDL Number:
- MFCD15071195
- MOL File:
- 194085-75-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Carisbamate ≥98% | 23514 | 500μg | $121 |
| Carisbamate ≥98% | 23514 | 1mg | $218 |
| (S)-Carisbamate | C183510 | 5mg | $215 |
| CARISBAMATE 95.00% | API0009416 | 1MG | $315 |
| (S)-Carisbamate | X3698 | 1mg | $340 |
| More product size | |||
| Melting point | 131-132°C |
|---|---|
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]/D +77 to +87°, c =0.2 in chloroform-d |
| InChI | 1S/C9H10ClNO3/c10-7-4-2-1-3-6(7)8(12)5-14-9(11)13/h1-4,8,12H,5H2,(H2,11,13)/t8-/m1/s1 |
| InChIKey | OLBWFRRUHYQABZ-MRVPVSSYSA-N |
| SMILES | ClC1=C([C@H](O)COC(N)=O)C=CC=C1 |
| FDA UNII | P7725I9V3Z |
| ATC code | N03AX19 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23514 | Carisbamate ≥98% | 194085-75-1 | 500μg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 23514 | Carisbamate ≥98% | 194085-75-1 | 1mg | $218 | 2024-03-01 | Buy |
| TRC | C183510 | (S)-Carisbamate | 194085-75-1 | 5mg | $215 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009416 | CARISBAMATE 95.00% | 194085-75-1 | 1MG | $315 | 2021-12-16 | Buy |
| AK Scientific | X3698 | (S)-Carisbamate | 194085-75-1 | 1mg | $340 | 2021-12-16 | Buy |
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Chemical Properties,Uses,Production
Description
Carisbamate is an antiepileptic agent., In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures. Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner. Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner. It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM.
Uses
Labelled Carisbamate; it is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizu re models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.
Uses
Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models.
Definition
ChEBI: Carisbamate is an organochlorine compound.
in vivo
Carisbamate (10, 30, 60 mg/kg; i.p.; single) dose dependently reduces the expression of spike-and-wave discharges (SWD) in absence seizures rat model[2].
Carisbamate (20, 30 mg/kg; i.p.; single) shows no wild running episode or tonic seizure occurres in any of the rats tested[2].
| Animal Model: | Male genetic absence epilepsy rat (absence seizures model)[2]. |
| Dosage: | 10, 30, 60 mg/kg |
| Administration: | Intraperitoneal injection; single. |
| Result: | Completely inhibited SWD when at 60 mg/kg after 120 min, and restored the duration of SWD to the control level when at 30 mg/kg after 100 min. |
| Animal Model: | Male Wistar audiogenic sensitive rat (convulsive seizures model)[2]. |
| Dosage: | 10, 20, 30 mg/kg |
| Administration: | Intraperitoneal injection; single. |
| Result: | Showed no wild running episode or tonic seizure occurred in any of the rats tested when at 20 and 30 mg/kg. Increased by 327% the latency to the tonic seizure that still occurred in the six of eight rats studied when at 10 mg/kg. |
References
[1] JENNIFER FRANOIS Astrid N Any Boehrer. Effects of Carisbamate (RWJ-333369) in Two Models of Genetically Determined Generalized Epilepsy, the GAERS and the Audiogenic Wistar AS[J]. Epilepsia, 2007, 49 3: 393-399. DOI: 10.1111/j.1528-1167.2007.01278.x
[2] HEIDI L. GRABENSTATTER F. E D. A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy[J]. Epilepsia, 2008, 49 10: 1787-1794. DOI: 10.1111/j.1528-1167.2008.01657.x
[3] YI LIU . Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons[J]. Epilepsy Research, 2009, 83 1: Pages 66-72. DOI: 10.1016/j.eplepsyres.2008.09.006
[4] DO YOUNG KIM. Carisbamate blockade of T-type voltage-gated calcium channels[J]. Epilepsia, 2017, 58 4: 617-626. DOI: 10.1111/epi.13710
2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15079 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49964 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19964 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 410 | 57 |
View Lastest Price from 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-25 | Carisbamate
194085-75-1
|
US $513.00-339.00 / mg | 99.94% | 10g | TargetMol Chemicals Inc. |
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- Carisbamate
194085-75-1
- US $513.00-339.00 / mg
- 99.94%
- TargetMol Chemicals Inc.
