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5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID structure

CAS No.: 849068-61-7

Chemical Name:: 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID

Synonyms: 5-Bromo-7-azaindole-3-car...;3-b]pyridine-3-carboxylic acid;5-BroMo-7-azaindole-3-carboxylic;5-Bromo-7-azaindole-3-carboxylic acid;5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic;5-Bromopyrrolo[2,3-b]pyridine-3-carboxylic Acid;5-bromo-1H-pyrrolo[5,4-b]pyridine-3-carboxylic acid;5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID;1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-bromo-

CBNumber:: CB11502728

Molecular Formula:: C8H5BrN2O2

Molecular Weight:: 241.04

MDL Number:: MFCD09965908

MOL File:: 849068-61-7.mol

MSDS File:: SDS

Last updated:2026-05-27 23:10:41

Product description	Number	Pack Size	Price
5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid Aldrich	ADE001006	1g	$870
5-Bromo-7-azaindole-3-carboxylic acid 97%	OR308043	250mg	$52
5-Bromo-7-azaindole-3-carboxylic acid 97%	OR308043	1g	$90
5-Bromo-7-azaindole-3-carboxylic acid 97%	OR308043	5g	$224
5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid	3H21-9-01	1g	$225
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5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Properties

Density	1.946±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
form	solid
pka	13.34±0.40(Predicted)
Appearance	White to off-white Solid
InChI	1S/C8H5BrN2O2/c9-4-1-5-6(8(12)13)3-11-7(5)10-2-4/h1-3H,(H,10,11)(H,12,13)
InChIKey	AFVRLQXVTZZPGE-UHFFFAOYSA-N
SMILES	OC(=O)c1c[nH]c2ncc(Br)cc12
UNSPSC Code	12352106

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H319
Precautionary statements	P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes	Xi,Xn
Risk Statements	22-36
Safety Statements	26-24/25
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	ADE001006	5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid Aldrich	849068-61-7	1g	$870	2026-04-30	Buy
Apolloscientific	OR308043	5-Bromo-7-azaindole-3-carboxylic acid 97%	849068-61-7	250mg	$52	2026-06-04	Buy
Apolloscientific	OR308043	5-Bromo-7-azaindole-3-carboxylic acid 97%	849068-61-7	1g	$90	2026-06-04	Buy
Apolloscientific	OR308043	5-Bromo-7-azaindole-3-carboxylic acid 97%	849068-61-7	5g	$224	2026-06-04	Buy
SynQuest Laboratories	3H21-9-01	5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid	849068-61-7	1g	$225	2026-05-22	Buy

Product number	Packaging	Price	Buy
ADE001006	1g	$870	Buy
OR308043	250mg	$52	Buy
OR308043	1g	$90	Buy
OR308043	5g	$224	Buy
3H21-9-01	1g	$225	Buy

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Chemical Properties,Uses,Production

Uses

5-Bromo-1H-pyrrolo[2,3-B]pyridine-3-carboxylic acid is an important raw material in organic synthesis. Its derivative, pyrrolopyridine-2-carboxamide, is a glycogen phosphorylase inhibitor used to prevent or treat diabetes, hypertension, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, atherosclerosis, or tissue ischemia, and can also be used as a cardioprotective agent.

Synthesis

76-02-8

183208-35-7

849068-61-7

The general procedure for the synthesis of 5-bromo-1H-pyrrolo[2,3-B]pyridine-3-carboxylic acid using 5-bromo-7-azaindole and trichloroacetyl chloride as starting materials was as follows: 5-bromo-7-azaindole (10.00 g, 50.75 mmol) was dissolved in dichloromethane (200 mL), followed by the addition of aluminum chloride (34.00 g, 254.99 mmol). stirred for 10 minutes at room temperature. Next, trichloroacetyl chloride (8.6 mL, 77 mmol) was added slowly and the reaction continued to be stirred at room temperature overnight. After completion of the reaction, the reaction mixture was slowly poured into ice water and filtered to collect the white solid. The filtrate was extracted with ethyl acetate (200 mL x 3). The organic phases were combined and concentrated to give a white solid. The solid was dissolved in water (125 mL), triethylamine (50 mL) was added and stirred at room temperature for 24 hours. At the end of the reaction, the solvent was concentrated to remove the solvent, the pH was adjusted to 5-6 with 1.0 M dilute hydrochloric acid, the product was collected by filtration and dried at 50 °C to give the final 5-bromo-1H-pyrrolo[2,3-B]pyridine-3-carboxylic acid (8.20 g, off-white solid) in 67.0% yield.

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 2052 - 2070
[2] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0557; 0558; 0559

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Trichloroacetyl chloride 5-Bromo-7-azaindole Dichloromethane Aluminum chloride

Preparation Products

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Suppliers

Global( 121)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5973	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8645	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	58
ANHUI WITOP BIOTECH CO., LTD	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CR Corporation Limited	58

View Lastest Price from 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-09	5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 849068-61-7	$9.80	1g	≥99%	100kg	Career Henan Chemical Co

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID
849068-61-7
$9.80
≥99%
Career Henan Chemical Co

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Spectrum

5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID(849068-61-7)¹HNMR

849068-61-7(5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID)Related Search:

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5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-bromo- 5-Bromo-7-azaindole-3-carboxylic acid 5-Bromo-7-azaindole-3-car... 3-b]pyridine-3-carboxylic acid 5-BroMo-7-azaindole-3-carboxylic 5-Bromopyrrolo[2,3-b]pyridine-3-carboxylic Acid 5-bromo-1H-pyrrolo[5,4-b]pyridine-3-carboxylic acid 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic 849068-61-7 1222175-20-4 CHIRAL CHEMICALS