(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- CAS No.
- 877397-65-4
- Chemical Name:
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- Synonyms
- (S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(S)-1-(2,6-Dichloro-3-fluorophenyl)ethano;(S)-1-(2,6-DichL;JACS-877397-65-4;Crizotinib Interm 7654;-1-(2,6-Dichloro-3-fluorophenyl);(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;(S)-1-(2,6-dichloro-4-fluorophenyl)ethanol;(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
- CBNumber:
- CB11503932
- Molecular Formula:
- C8H7Cl2FO
- Molecular Weight:
- 209.04
- MDL Number:
- MFCD09863793
- MOL File:
- 877397-65-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 273277 | 1g | $319 |
| S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 273277 | 2g | $438 |
| S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 273277 | 5g | $602 |
| S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 273277 | 10g | $814 |
| S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 273277 | 25g | $1097 |
| More product size | |||
| Boiling point | 261.3±35.0 °C(Predicted) |
|---|---|
| Density | 1.406±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 13.30±0.20(Predicted) |
| form | Solid |
| color | White |
| InChI | InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3 |
| InChIKey | JAOYKRSASYNDGH-UFLUHPNLNA-N |
| SMILES | [C@H](C1C(=CC=C(F)C=1Cl)Cl)(O)C |&1:0,r| |
| CAS DataBase Reference | 877397-65-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2906290090 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 273277 | S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 877397-65-4 | 1g | $319 | 2026-06-03 | Buy |
| Usbiological | 273277 | S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 877397-65-4 | 2g | $438 | 2026-06-03 | Buy |
| Usbiological | 273277 | S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 877397-65-4 | 5g | $602 | 2026-06-03 | Buy |
| Usbiological | 273277 | S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 877397-65-4 | 10g | $814 | 2026-06-03 | Buy |
| Usbiological | 273277 | S-1-(2,6-Dichloro-3-fluorophenyl)ethanol Asreported | 877397-65-4 | 25g | $1097 | 2026-06-03 | Buy |
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Chemical Properties,Uses,Production
Uses
(S) -1- (2,6-dichloro-3-fluorophenyl) ethanol(C8H7C12FO) is synthesized (R)-3-[l-(2, 6-dichloro-3-fluoro-benzene)- The key intermediate of ethoxy-5- (l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -pyrimidine-2-indane. And (R)-3-[l-(2,6-dichloro-3-fluoro-benzene)-ethoxy-5-(l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -Pyrimidine-2-indane is a small molecule kinase inhibitor for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) positive for anaplastic lymphohematokinase (ALK).
Uses
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
Synthesis
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is synthesised using (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate as a raw material by chemical reaction. The specific synthesis steps are as follows:
Sodium methoxide (19 mmol; 0.5 M in methanol) was added slowly to compound S-2 (4.64 g, 18.8 mmol) under a nitrogen atmosphere at 0° C. The resulting mixture was stirred at room temperature for 4 hours. The solvent was evaporated and H2O (100 mL) was added. The cooled reaction mixture was neutralized with sodium acetate-acetic acid buffer solution to pH 7. Ethyl acetate (100 mL.x.2) was added to extract the aqueous solution. The combined organic layers were dried over Na2SO4, filtered, and evaporated to obtain S-1 as a white solid (4.36 g, 94.9percent yield); SFC-MS: 97percent ee. 1H NMR (400 MHz, chloroform-D) δ ppm 1.65 (d, J=6.8 Hz, 3 H) 5.58 (q, J=6.9 Hz, 1H) 6.96-7.10 (m, 1H) 7.22-7.36 (m, 1H).
References
[1] Patent: CN105237346, 2016, A. Location in patent: Paragraph 0050; 0051; 0052; 0053; 0054; 0055; 0056-0061
[2] Patent: WO2012/48259, 2012, A2. Location in patent: Page/Page column 38-39
[3] Patent: WO2012/48258, 2012, A2. Location in patent: Page/Page column 31-32
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 21, p. 6804 - 6820
[5] Patent: WO2013/17989, 2013, A1
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| SyncoZymes (Shanghai) Co., Ltd., | +8613681683526 | lchen@syncozymes.com | China | 286 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
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View Lastest Price from (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-20 | (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-15 | (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
|
1kg | ＞98% by HPLC | 10kg/month | Zison Pharmaceutical (Shandong) Co., Ltd. | ||
 |
2025-12-12 | 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9
|
10g | 99%+ | 10000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
877397-65-4
- ＞98% by HPLC
- Zison Pharmaceutical (Shandong) Co., Ltd.
-
- 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
253870-02-9
- 99%+
- Shaanxi Dideu Medichem Co. Ltd
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