ChemicalBook >> CAS DataBase List >>3-BROMOIMIDAZO[1,2-B]PYRIDAZINE

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE structure

CAS No.: 18087-73-5

Chemical Name:: 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE

Synonyms: Ponatinib Impurity 2;Ponatinib intermediate;3-BroMoiMidazo[1,2-b]pyri...;3-broMoiMidazo(1,2-b)pyridazin;3-BROMOIMIDAZO[1,2-B]PYRIDAZINE;IMidazo[1,2-b]pyridazine, 3-broMo-;3-Bromoimidazo[1,2-b]pyridazine >3-Bromoimidazo[1,2-b]pyridazine;3-Bromo-4-Hydroimidazo[1,2-e]Pyridazine;3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 18087-73-5

CBNumber:: CB11515636

Molecular Formula:: C6H4BrN3

Molecular Weight:: 198.02

MDL Number:: MFCD09757672

MOL File:: 18087-73-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:09:17

Product description	Number	Pack Size	Price
3-Bromoimidazo[1,2-b]pyridazine >98.0%(GC)(T)	B4652	1g	$34
3-Bromoimidazo[1,2-b]pyridazine	FB33555	50g	$900
3-Bromoimidazo[1,2-b]pyridazine	FB33555	25g	$900
3-Bromoimidazo[1,2-b]pyridazine	FB33555	200g	$900
3-Bromoimidazo[1,2-b]pyridazine	FB33555	100g	$900
More product size

Request For Quotation

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Properties

Melting point	148.0 to 152.0 °C
Density	1.89
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	2.35±0.30(Predicted)
form	powder to crystal
color	White to Light yellow
InChI	InChI=1S/C6H4BrN3/c7-5-4-8-6-2-1-3-9-10(5)6/h1-4H
InChIKey	KJQVHOFAWISYDO-UHFFFAOYSA-N
SMILES	C12=NC=C(Br)N1N=CC=C2
CAS DataBase Reference	18087-73-5

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P280-P305+P351+P338-P310
Hazard Codes	Xn
Risk Statements	22
Safety Statements	24/25
HS Code	29339900

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B4652	3-Bromoimidazo[1,2-b]pyridazine >98.0%(GC)(T)	18087-73-5	1g	$34	2026-04-30	Buy
Biosynth	FB33555	3-Bromoimidazo[1,2-b]pyridazine	18087-73-5	50g	$900	2026-06-04	Buy
Biosynth	FB33555	3-Bromoimidazo[1,2-b]pyridazine	18087-73-5	25g	$900	2026-06-04	Buy
Biosynth	FB33555	3-Bromoimidazo[1,2-b]pyridazine	18087-73-5	200g	$900	2026-06-04	Buy
Biosynth	FB33555	3-Bromoimidazo[1,2-b]pyridazine	18087-73-5	100g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
B4652	1g	$34	Buy
FB33555	50g	$900	Buy
FB33555	25g	$900	Buy
FB33555	200g	$900	Buy
FB33555	100g	$900	Buy

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Chemical Properties,Uses,Production

Uses

3-Bromoimidazo[1,2-B]pyridazine is a pharmaceutical intermediate compound. It is used in the preparation of Ponatinib, a tyrosine kinase inhibitor (TKI), which is used in the treatment of chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL).

Synthesis

766-55-2

18087-73-5

Imidazo[1,2-b]pyridazine (6.0 g, 50.4 mmol) was used as starting material, and N-bromosuccinimide (NBS, 6.0 g, 75.6 mmol) and a catalytic amount of azobisisobutyronitrile (AIBN) were added in 50 mL of chloroform. The reaction mixture was heated and refluxed for 2 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and subsequently stirred under ice bath conditions to promote precipitation. The precipitate was separated by filtration and the filtrate was concentrated to afford the target product 3-bromoimidazo[1,2-b]pyridazine as a pale yellow solid in 75% yield.

References

[1] Patent: CN105418615, 2016, A. Location in patent: Paragraph 0079 ; 0080 ; 0081; 0082; 0083; 0084
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 23, p. 5830 - 5835
[3] Patent: EP2818471, 2014, A1. Location in patent: Paragraph 0122; 0123
[4] Synthesis, 1981, # 12, p. 987 - 989
[5] Patent: WO2016/210036, 2016, A1. Location in patent: Page/Page column 107

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Preparation Products And Raw materials

Raw materials

Imidazo[1,2-b]pyridazine N-Bromosuccinimide AIBN Chloroform

Preparation Products

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Suppliers

Global( 292)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Changzhou Ditong Chemical Co.,Ltd	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-30	3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 18087-73-5		1KG	98%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2025-11-18	3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 18087-73-5	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-04-04	3-bromoimidazo[1,2-b]pyridazine 18087-73-5		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
18087-73-5
98%
Shenzhen Nexcon Pharmatechs Ltd.

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
18087-73-5
$1.10
99.00%
Dideu Industries Group Limited

3-bromoimidazo[1,2-b]pyridazine
18087-73-5
98%
Henan Aochuang Chemical Co.,Ltd.

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Spectrum

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE(18087-73-5)¹HNMR

18087-73-5(3-BROMOIMIDAZO[1,2-B]PYRIDAZINE)Related Search:

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 1-Methyl-4-[[4-nitro-2-(trifluoromethyl)phenyl]methyl]-piperazine BenzaMide, 3-iodo-4-Methyl-N-[4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)phenyl]- 3-Bromoimidazo[1,2-a]pyrimidine 3-Ethynylimidazo[1,2-b]pyridazine

4-Methyl-3-(trifluoromethyl)aniline 3-Iodo-4-methylbenzoic acid 2-METHYL-5-NITROBENZOTRIFLUORIDE 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 3-Bromo-6-chloroimidazo[1,2-b]pyridazine

Imidazo[1,2-b]pyridazine 3,8-DIBROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE 3-BROMO-6-CHLORO-2-PHENYL-IMIDAZO[1,2-B]PYRIDAZINE 3-Bromo-2-phenylimidazo[1,2-b]pyridazine 3-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-b]pyridazine

3-Bromo-6-piperidin-1-yl-imidazo[1,2-b]pyridazine 3-BROMO-7-METHYL-IMIDAZO[1,2-B]PYRIDAZINE 3-Bromo-6-pyrrolidin-1-yl-imidazo[1,2-b]pyridazine

1of4

IMidazo[1,2-b]pyridazine, 3-broMo- 3-BroMoiMidazo[1,2-b]pyri... 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 3-broMoiMidazo(1,2-b)pyridazin 3-Bromoimidazo[1,2-b]pyridazine Ponatinib Impurity 2 Ponatinib intermediate 3-Bromoimidazo[1,2-b]pyridazine > 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 18087-73-5 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE ISO 9001：2015 REACH 3-Bromo-4-Hydroimidazo[1,2-e]Pyridazine 18087-73-5