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ChemicalBook >> CAS DataBase List >>2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Structure
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide structure
CAS No.
946387-07-1
Chemical Name:
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
Synonyms
PM-0016;RN 1734;RN-1734, 10 mM in DMSO;RN-1734, TRPV4 antagonist;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide;RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide);2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734)
CBNumber:
CB11529521
Molecular Formula:
C14H22Cl2N2O2S
Molecular Weight:
353.31
MDL Number:
MFCD00129453
MOL File:
946387-07-1.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02
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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Properties

storage temp. 2-8°C
solubility DMSO: >20mg/mL
form Yellow solid
color white to off-white
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  nwg

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R0658 RN-1734 ≥98% (HPLC) 946387-07-1 5mg $84.1 2024-03-01 Buy
Sigma-Aldrich 616520 TRPV4 Antagonist I, RN-1734 946387-07-1 10mg $111 2024-03-01 Buy
Cayman Chemical 24205 RN-1734 ≥98% 946387-07-1 5mg $61 2024-03-01 Buy
Cayman Chemical 24205 RN-1734 ≥98% 946387-07-1 10mg $95 2024-03-01 Buy
Sigma-Aldrich R0658 RN-1734 ≥98% (HPLC) 946387-07-1 25mg $335 2024-03-01 Buy
Product number Packaging Price Buy
R0658 5mg $84.1 Buy
616520 10mg $111 Buy
24205 5mg $61 Buy
24205 10mg $95 Buy
R0658 25mg $335 Buy

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Chemical Properties,Uses,Production

Uses

RN 1734 is a novel TRPV4 modulator.

Uses

RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.

General Description

A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 μM).

Biological Activity

Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).

Biochem/physiol Actions

RN-1734 is a selective TRPV4 antagonist.

storage

+4°C

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Suppliers

Global( 88)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jk.info@jkchemical.com China 96815 76
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		58
Amadis Chemical Company Limited 		58
J & K SCIENTIFIC LTD. 76

View Lastest Price from 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RN-1734 pictures 2024-11-19 RN-1734
946387-07-1
 US $41.00-131.00 / mg 99.30% 10g TargetMol Chemicals Inc.
  • RN-1734 pictures
  • RN-1734
    946387-07-1
  • US $41.00-131.00 / mg
  • 99.30%
  • TargetMol Chemicals Inc.

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Spectrum

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide(946387-07-1)1HNMR

946387-07-1(2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide)Related Search:

5-METHYL-N,N-DIMETHYLTRYPTAMINE Cumene N-Isopropylacrylamide N-Isopropylbenzylamine N-Methyl-2-pyrrolidone
RN-1 (hydrochloride) RKI1447 RN486

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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide RN 1734 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734) 2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide TRPV4 Antagonist I, RN-1734 TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]- RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide) PM-0016 RN1734,Inhibitor,RN-1734,Transient receptor potential channels,TRP Channel,inhibit,RN 1734 RN-1734, TRPV4 antagonist RN-1734, 10 mM in DMSO 946387-07-1