2-(4-Methoxyphenyl)thiazole-5-carbaldehyde
- CAS No.
- 914348-82-6
- Chemical Name:
- 2-(4-Methoxyphenyl)thiazole-5-carbaldehyde
- Synonyms
- 2-(4-Methoxyphenyl)thiazole-5-carbaldehyde;2-(4-Methoxyphenyl)-5-thiazolecarboxaldehyde;5-Thiazolecarboxaldehyde, 2-(4-methoxyphenyl)-
- CBNumber:
- CB1160185
- Molecular Formula:
- C11H9NO2S
- Molecular Weight:
- 219.26
- MDL Number:
- MFCD05864660
- MOL File:
- 914348-82-6.mol
- MSDS File:
- SDS
| Boiling point | 387.6±48.0 °C(Predicted) |
|---|---|
| Density | 1.266±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 1.04±0.10(Predicted) |
| InChI | InChI=1S/C11H9NO2S/c1-14-9-4-2-8(3-5-9)11-12-6-10(7-13)15-11/h2-7H,1H3 |
| InChIKey | DFJPGTVCVKDDEY-UHFFFAOYSA-N |
| SMILES | S1C(C=O)=CN=C1C1=CC=C(OC)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Risk Statements | 36 |
| Safety Statements | 26 |
| HazardClass | IRRITANT |
2-(4-Methoxyphenyl)thiazole-5-carbaldehyde price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 064623 | 2-(4-Methoxyphenyl)-1,3-thiazole-5-carbaldehyde | 914348-82-6 | 500.00mg | $315 | 2026-05-18 | Buy |
| Synthonix | M55376 | 2-(4-Methoxyphenyl)thiazole-5-carbaldehyde 98% | 914348-82-6 | 100mg | $150 | 2026-05-06 | Buy |
| Synthonix | M55376 | 2-(4-Methoxyphenyl)thiazole-5-carbaldehyde 98% | 914348-82-6 | 250mg | $250 | 2026-05-06 | Buy |
| Synthonix | M55376 | 2-(4-Methoxyphenyl)thiazole-5-carbaldehyde 98% | 914348-82-6 | 1g | $550 | 2026-05-06 | Buy |
| Synthonix | M55376 | 2-(4-Methoxyphenyl)thiazole-5-carbaldehyde 98% | 914348-82-6 | 5g | $2750 | 2026-05-06 | Buy |
2-(4-Methoxyphenyl)thiazole-5-carbaldehyde Chemical Properties,Uses,Production
Synthesis
27088-84-2
68-12-2
914348-82-6
1. Palladium acetate (0.82 g, 3.66 mmol), triphenylphosphine (4.80 g, 18.29 mmol) and 2 M aqueous sodium carbonate (183.0 mL, 366.0 mmol) were sequentially added under nitrogen protection to a DMF (400 mL) solution containing 2-bromothiazole (20.00 g, 121.94 mmol) and 4-methoxyphenylboronic acid (25.94 g, 170.71 mmol). 170.71 mmol) in a solution of DMF (400 mL). The reaction mixture was stirred at 100 °C for 3 hours. After completion of the reaction, water was added to the reaction solution and extracted with a solvent mixture of ethyl acetate and toluene (1:1, v/v). The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to give a yellow oily thiazole derivative (20.40 g, 88% yield). 2. n-Butyllithium (2.64 M hexane solution, 52.5 mL, 138.67 mmol) was slowly added dropwise to a solution of THF (500 mL) of the above thiazole derivative (20.40 g, 106.67 mmol) at -78 °C and under nitrogen protection. After the dropwise addition, stirring was continued at -78 °C for 2 hours. Subsequently, DMF (16.4 mL, 213.33 mmol) was added slowly dropwise and the reaction system was slowly warmed to 0 °C and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched by dropwise addition of acetic acid (7.9 mL, 138.67 mmol) and the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate and partitioned by adding water. The aqueous phase was extracted with ethyl acetate, the organic phases were combined, washed with water and saturated brine sequentially, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was recrystallized with diisopropyl ether to obtain 2-(4-methoxyphenyl)thiazole-5-carbaldehyde (18.31 g, 78% yield) as yellow powder.
References
[1] Patent: EP2308838, 2011, A1. Location in patent: Page/Page column 69
2-(4-Methoxyphenyl)thiazole-5-carbaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Born Pharmaceutical Co., Ltd. | 13261021908 | 1198872622@qq.com | China | 949 | 55 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Scientia Pharmaceutical Technology Co., Ltd. | 21-21-54301573 13917723525 | sales@scientiapharm.com | China | 260 | 62 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Civic Chemical Technology Co., Ltd. | 021-34053660 | sale2@labgogo.com | China | 2018 | 58 |
