2-Pyridinol-1-oxide
- CAS No.
- 13161-30-3
- Chemical Name:
- 2-Pyridinol-1-oxide
- Synonyms
- HOPO;2-HYDROXYPYRIDINE 1-OXIDE;2-HYDROXYPYRIDINE N-OXIDE;HPNO;1-oxide;1-HYDROXY-2-PYRIDONE;1-hydroxypyridin-2-one;2-Hydorxy Pyridine-N-Oxide;2-HYDROXYPYRIDINE N-OXIDE 98%;2-pyridinol-1-oxide
- CBNumber:
- CB1168000
- Molecular Formula:
- C5H5NO2
- Molecular Weight:
- 111.1
- MDL Number:
- MFCD00006195
- MOL File:
- 13161-30-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Pyridinol 1-oxide ≥98.0% (N) | 56413 | 25g | $132 |
| 2-Pyridinol 1-oxide ≥98.0% (N) | 56413 | 100g | $288 |
| 2-Hydroxypyridine N-Oxide >98.0%(T) | H0672 | 25g | $42 |
| 2-Hydroxypyridine N-Oxide | 278689 | 50g | $330 |
| 2-Hydroxypyridine N-Oxide | H953633 | 25g | $70 |
| More product size | |||
| Melting point | 147-152 °C |
|---|---|
| Boiling point | 387.7±15.0 °C(Predicted) |
| Density | 1.111 |
| vapor pressure | 0.223Pa at 25℃ |
| refractive index | 1.388 |
| Flash point | 100 °C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| pka | pK1:-0.62;pK2:5.97(0) (25°C) |
| form | Solid |
| color | Off-White to Light Yellow |
| Water Solubility | 331g/L |
| BRN | 1422545 |
| InChI | 1S/C5H5NO2/c7-5-3-1-2-4-6(5)8/h1-4,7H |
| InChIKey | JVHZMYAXZUIZKS-UHFFFAOYSA-N |
| SMILES | Oc1cccc[n+]1[O-] |
| LogP | -1.07 at 25℃ |
| CAS DataBase Reference | 13161-30-3(CAS DataBase Reference) |
| FDA UNII | YO3915897S |
| NIST Chemistry Reference | 2-Pyridinol-1-oxide(13161-30-3) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-40 | |||||||||
| Safety Statements | 26-36-22 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Pyridinol-1-oxide price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 56413 | 2-Pyridinol 1-oxide ≥98.0% (N) | 13161-30-3 | 25g | $132 | 2026-03-19 | Buy |
| Sigma-Aldrich | 56413 | 2-Pyridinol 1-oxide ≥98.0% (N) | 13161-30-3 | 100g | $288 | 2026-03-19 | Buy |
| TCI Chemical | H0672 | 2-Hydroxypyridine N-Oxide >98.0%(T) | 13161-30-3 | 25g | $42 | 2026-03-19 | Buy |
| Usbiological | 278689 | 2-Hydroxypyridine N-Oxide | 13161-30-3 | 50g | $330 | 2021-12-16 | Buy |
| TRC | H953633 | 2-Hydroxypyridine N-Oxide | 13161-30-3 | 25g | $70 | 2021-12-16 | Buy |
2-Pyridinol-1-oxide Chemical Properties,Uses,Production
Chemical Properties
Weight 20% solution in water
Uses
2-Pyridinol 1-oxide can be used:
- To fabricate gold electrodes for the electrochemical determination of europium using cyclic voltammetry.
- To prepare polymeric nickel (II) complex of 2-hydroxypyridine-N-oxide.
- In the synthesis of 1-methoxypyrid-4-one in the presence of sodium methoxide and methyl toluene-9-sulphonate.
Definition
Bactericidal agent related to aspergillic acid, made from pyridine-N-oxide.
General Description
2-Pyridinol 1-oxide (HOPO) is a peptide coupling agent used as a subsititue for HOBt. It can form stable chelate complexes with transition metal ions.
Synthesis
500L reactor add 2-chloropyridine 30 kg, 200 kg of tap water, sodium tungstate 1.5 kg, 2 kg of concentrated sulfuric acid, stirring to dissolve clear; temperature to 55 , slowly drop 30% hydrogen peroxide 100 kg; drop after the completion of the temperature to continue to react for 48 hours, HPLC test raw material conversion rate of 84%, cooled down to room temperature, add 12.3 kg of liquid alkali adjusted to neutral. Add toluene 50 kg, extract the raw material is not fully reacted (the layer can be concentrated to recover toluene and raw materials); aqueous layer to add 20 kg of sodium hydroxide, reflux reaction for 8 hours, HPLC monitoring, showing that the raw material is fully converted, cooled down to 25 C, add hydrochloric acid to adjust the PH = 6, add ethyl acetate extraction, each time the dosage of 30 kg, extract three times, the combined organic phase, with anhydrous sodium sulfate 15 kg drying ; filter, concentrate the organic phase to 1/5 of the original volume, add 85 kg of 60-90 C petroleum ether, cooled to -5 C, stirring crystallization; filtration, drying, to obtain a light yellow crystal powder 22.9 kg, yield: 78.05% (calculated as 2-chloropyridine, and did not calculate the recovery of 2-chloropyridine).
References
[1] Laura Cruickshank. “Rare Elements Electrochemistry: The Development of a Novel Electrochemical Sensor for the Rapid Detection of Europium in Environmental Samples Using Gold Electrode Modified with 2-pyridinol-1-oxide.” Analytical Sciences 31 7 (2015): 623–627.
2-Pyridinol-1-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 489 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Hangzhou Verychem Science And Technology Co.Ltd | +86-86-57188162785 13606544505 | lucy@verychem.com | China | 1193 | 58 |
| Jinan Dexinjia Bio&Tech Co., Ltd | +86-0531-82375818 +86-15064153060 | sales@jndxj.com | China | 1290 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21591 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
View Lastest Price from 2-Pyridinol-1-oxide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2-Pyridinol-1-oxide
13161-30-3
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-06-27 | 2-Pyridinol-1-oxide
13161-30-3
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-20 | 2-Pyridinol-1-oxide
13161-30-3
|
US $20.00-5.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- 2-Pyridinol-1-oxide
13161-30-3
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 2-Pyridinol-1-oxide
13161-30-3
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Pyridinol-1-oxide
13161-30-3
- US $20.00-5.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
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