QX 314 chloride
- CAS No.
- 5369-03-9
- Chemical Name:
- QX 314 chloride
- Synonyms
- QX314.Cl;QX 314 CHLORIDE;N-Ethyllidocaine chloride;Lidocaine N-ethyl chloride;QX-314 chloride, 10 mM in DMSO;QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;QX-314 chloride (N-Ethyllidocaine chloride), Na+ channel blocker;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride
- CBNumber:
- CB1191994
- Molecular Formula:
- C16H27ClN2O
- Molecular Weight:
- 298.85
- MDL Number:
- MFCD01669894
- MOL File:
- 5369-03-9.mol
| Melting point | 209-211 °C |
|---|---|
| storage temp. | Room temp |
| solubility | insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O |
| form | solid |
| color | White |
| Water Solubility | Soluble in water (100mM) |
| InChI | InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H |
| InChIKey | LLPPOMUAOGMYQI-UHFFFAOYSA-N |
| SMILES | C1(=C(C)C=CC=C1C)NC(=O)C[N+](CC)(CC)CC.[Cl-] |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
QX 314 chloride price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L1663 | Lidocaine N-ethyl chloride | 5369-03-9 | 500MG | $331.55 | 2025-07-31 | Buy |
| Sigma-Aldrich | L1663 | Lidocaine N-ethyl chloride | 5369-03-9 | 1G | $611 | 2025-07-31 | Buy |
| Cayman Chemical | 18454 | QX-314 (chloride) ≥98% | 5369-03-9 | 50mg | $121 | 2024-03-01 | Buy |
| Tocris | 2313 | QX314chloride ≥99%(HPLC) | 5369-03-9 | 50 | $139 | 2021-12-16 | Buy |
| TRC | Q950010 | QX314Chloride | 5369-03-9 | 50mg | $130 | 2021-12-16 | Buy |
QX 314 chloride Chemical Properties,Uses,Production
Uses
QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.
Uses
QX 314 Chloride has been shown to have antitussive properties in mammalian animal models.
Biological Activity
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.
Biochem/physiol Actions
Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.
storage
Room temperature
QX 314 chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32431 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20601 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Universal Biotech Co.,Ltd | 19301387927 19301387927 | yh-wang@univ-bio.com | China | 25005 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 | info@yuhaochemical.com | China | 6387 | 52 |
View Lastest Price from QX 314 chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-15 | QX-314 chloride
5369-03-9
|
US $132.00-48.00 / mg | 99.84% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-09-15 | QX-314 chloride
5369-03-9
|
US $132.00-48.00 / mg | 99.84% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-05-13 | QX 314 chloride
5369-03-9
|
US $1.10 / g | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited |
-
- QX-314 chloride
5369-03-9
- US $132.00-48.00 / mg
- 99.84%
- TargetMol Chemicals Inc.
-
- QX-314 chloride
5369-03-9
- US $132.00-48.00 / mg
- 99.84%
- TargetMol Chemicals Inc.
-
- QX 314 chloride
5369-03-9
- US $1.10 / g
- 99.0% Min
- Dideu Industries Group Limited
