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2,5-Diamino-4,6-dichloropyrimidine

2,5-Diamino-4,6-dichloropyrimidine structure

CAS No.: 55583-59-0

Chemical Name:: 2,5-Diamino-4,6-dichloropyrimidine

Synonyms: AKOS 90003;2,5-Diamino-4,6-Dichloropyrimi;dichloropyriMidine-2,5-diaMine;4,6-Dichlorpyrimidin-2,5-diamin;4,6-Dichlorpyrimidine-2,5-diamine;4,6-DICHLOROPYRIMIDINE-2,5-DIAMINE;2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE;4,6-dichloro-2,5-diaminopyrimidine;2,5-PYRIMIDINEDIAMINE, 4,6-DICHLORO;4,6-Dichloro-2,5-diamine pyrimidine

CBNumber:: CB1197259

Molecular Formula:: C4H4Cl2N4

Molecular Weight:: 179.01

MDL Number:: MFCD00792652

MOL File:: 55583-59-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:12

Product description	Number	Pack Size	Price
2,5-Diamino-4,6-dichloropyrimidine >98.0%(GC)(T)	D4231	1g	$23
2,5-Diamino-4,6-dichloropyrimidine >98.0%(GC)(T)	D4231	5g	$69
2,5-Diamino-4,6-dichloropyrimidine	D415110	250mg	$50
2,5-Diamino-4,6-dichloropyrimidine	295994	10g	$531
2,5-Diamino-4,6-dichloropyrimidine	FD16293	100g	$400
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2,5-Diamino-4,6-dichloropyrimidine Properties

Melting point	188-191 °C (decomp)
Boiling point	395.8±52.0 °C(Predicted)
Density	1.715±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO, Methanol (Slightly), Water (Slightly)
form	Solid
pka	1.08±0.10(Predicted)
color	Pale Red to Light Red
InChI	InChI=1S/C4H4Cl2N4/c5-2-1(7)3(6)10-4(8)9-2/h7H2,(H2,8,9,10)
InChIKey	ZXWGHENZKVQKPX-UHFFFAOYSA-N
SMILES	C1(N)=NC(Cl)=C(N)C(Cl)=N1
CAS DataBase Reference	55583-59-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes	Xi
Hazard Note	Irritant
HS Code	2933599590

2,5-Diamino-4,6-dichloropyrimidine price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D4231	2,5-Diamino-4,6-dichloropyrimidine >98.0%(GC)(T)	55583-59-0	1g	$23	2026-03-19	Buy
TCI Chemical	D4231	2,5-Diamino-4,6-dichloropyrimidine >98.0%(GC)(T)	55583-59-0	5g	$69	2026-03-19	Buy
TRC	D415110	2,5-Diamino-4,6-dichloropyrimidine	55583-59-0	250mg	$50	2021-12-16	Buy
Usbiological	295994	2,5-Diamino-4,6-dichloropyrimidine	55583-59-0	10g	$531	2021-12-16	Buy
Biosynth Carbosynth	FD16293	2,5-Diamino-4,6-dichloropyrimidine	55583-59-0	100g	$400	2021-12-16	Buy

Product number	Packaging	Price	Buy
D4231	1g	$23	Buy
D4231	5g	$69	Buy
D415110	250mg	$50	Buy
295994	10g	$531	Buy
FD16293	100g	$400	Buy

2,5-Diamino-4,6-dichloropyrimidine Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

2,5-Diamino-4,6-dichloropyrimidine is used as building block in chemical synthesis.

Uses

2,5-Diamino-4,6-dichloropyrimidine is a useful reagent for the preparation of Abacavir impurities, carbocyclic and hexenopyranosy nucleosides.

Synthesis

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

56830-58-1

55583-59-0

General procedure for the synthesis of 2,5-diamino-4,6-dihydroxypyrimidine hydrochloride from 2,5-diamino-4,6-dichloropyrimidine hydrochloride: 2,5-diamino-4,6-dihydroxypyrimidine hydrochloride (0.14 mol, 25 g) was placed in a dry reactor, and dry 1,2,3-trichloropropane (51.96 mL) was added and stirred. Subsequently, tetramethylammonium chloride (0.29 mol, 31.25 g) and phosphorous trichloride (0.54-0.81 mol, 83.28-124.9 g, 50.6-75.9 mL) were added sequentially. The reaction mixture was heated to reflux (about 115°C) and maintained for 24 hours. Upon completion of the reaction, it was cooled to below 50°C and ice water (24.44 mol, 440.44 g) was added slowly, keeping the temperature below 55°C. The pH was adjusted to 6.5-7.0 with 50% sodium hydroxide solution (3.12 mol, 124.92 g, 163.3 mL), keeping the temperature below 55°C, and stirring was continued for 30 minutes. Subsequently, the reaction mixture was stirred at 50-60°C and tetrahydrofuran (3.7 mol, 267.0 g, 300 mL) was added. Insoluble material was removed by diatomaceous earth filtration and the filter cake was washed with ethyl acetate (20.5 mol, 1806.58 g, 2002.86 mL). The organic phases (tetrahydrofuran and ethyl acetate) were combined, washed three times with water (5.57 mol, 100.32 g, 100.32 L), dried with sodium bicarbonate and filtered. Ethyl acetate was removed by vacuum distillation, hexane (0.77 mol, 66.14 g, 100.36 mL) was added to the residue, cooled to below 10°C, filtered, and the resulting solid was dried in vacuo at 50°C to afford the title product, 2,5-diamino-4,6-dichloropyrimidine (0.09 mol, 15.71 g), as a slightly brownish solid in about 65% yield .

References

[1] Patent: EP1188750, 2002, A1. Location in patent: Page 5
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 2, p. 655 - 668
[3] Patent: US2012/46278, 2012, A1. Location in patent: Page/Page column 75
[4] Patent: US2013/190297, 2013, A1. Location in patent: Paragraph 1123
[5] Patent: US2014/88088, 2014, A1. Location in patent: Paragraph 1138

2,5-Diamino-4,6-dichloropyrimidine Preparation Products And Raw materials

Raw materials

Sodium dithionite Acetonitrile Benzyltriethylammonium chloride Ethanol 2-AMINODIETHYLMALONATE

Sodium chloride Sodium Phosphorus oxitrichloride 2-Amino-4,6-dihydroxypyrimidine Sodium nitrite

Phosphorus pentachloride Guanidine hydrochloride Ethyl acetate Hydrochloric acid Triethylmethylammonium chloride

Sodium hydroxide Magnesium sulfate Ammonia

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Preparation Products

2,5-Diamino-4,6-dichloropyrimidine Suppliers

Global( 293)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
HaBo Hong Kong Co., Limited.	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2,5-Diamino-4,6-dichloropyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-12	2,5-Diamino-4,6-dichloropyrimidine 55583-59-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02	2,5-Diamino-4,6-dichloropyrimidine 55583-59-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-05-15	2,5-Diamino-4,6-dichloropyrimidine 55583-59-0	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd

2,5-Diamino-4,6-dichloropyrimidine
55583-59-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2,5-Diamino-4,6-dichloropyrimidine
55583-59-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2,5-Diamino-4,6-dichloropyrimidine
55583-59-0
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

2,5-Diamino-4,6-dichloropyrimidine Spectrum

2,5-Diamino-4,6-dichloropyrimidine(55583-59-0)¹HNMR 2,5-Diamino-4,6-dichloropyrimidine(55583-59-0)¹³CNMR

55583-59-0(2,5-Diamino-4,6-dichloropyrimidine)Related Search:

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Iminodiacetic acid HYDRAZINE 4,4'-Methylenedianiline 2,5-Diamino-4,6-dichloropyrimidine hydrochloride N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride 2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE,97% 2,5-Diamino-4,6-dichloropyrimidine

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AKOS 90003 2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE 98+% 4,6-DICHLOROPYRIMIDINE-2,5-DIAMINE 2,5-PYRIMIDINEDIAMINE, 4,6-DICHLORO 2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE 2,5-Diamino-4,6-Dichloropyrimi 4,6-Dichlorpyrimidine-2,5-diamine (2-amino-4,6-dichloro-pyrimidin-5-yl)amine 2,5-Diamino-4,6-dichloropyrimidine, 2,5-Diamino-4,6-dichloro-1,3-diazine dichloropyriMidine-2,5-diaMine 2,5-Diamino-4,6-dichloropyrimidine> 2,5-DIAMINO-4,6-DICHLOROPYRIMIDINE,CAS:55583-59-0 4,6-Dichlorpyrimidin-2,5-diamin 4,6-dichloro-2,5-diaminopyrimidine 4,6-Dichloro-2,5-diamine pyrimidine 55583-59-0 55-52-4 5583-59-0 C4H4N4Cl2 C4H4Cl2N4 Heterocycle-Pyrimidine series Pyrimidines various pyrimidines APIs & Intermediate Pyrimidine