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4-Hydrazinobenzene-1-sulfonamide hydrochloride

4-Hydrazinobenzene-1-sulfonamide hydrochloride structure

CAS No.: 17852-52-7

Chemical Name:: 4-Hydrazinobenzene-1-sulfonamide hydrochloride

Synonyms: BENZENESULPHONAMIDE;Celecoxib Intermediate;4-Hydrazinobenzene-1-sulfonaMide;4-Sulfonamidophenylhydrazine hydrochloride;4-SPH;4SPHH;4-SAPH.HCl;fonamide HydrochL;4-SPH/Sulfonamide;4-Hydrazinobenzene-1

CBNumber:: CB1200737

Molecular Formula:: C6H10ClN3O2S

Molecular Weight:: 223.68

MDL Number:: MFCD00052262

MOL File:: 17852-52-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:12:10

Product description	Number	Pack Size	Price
4-sulfonamidophenylhydrazine hydrochloride AldrichCPR	CDS003887	250mg	$81.6
4-Hydrazinobenzenesulfonamide Hydrochloride >98.0%(HPLC)(T)	H1230	5g	$28
4-Hydrazinobenzenesulfonamide Hydrochloride >98.0%(HPLC)(T)	H1230	25g	$86
4-(Sulfamoylphenyl) hydrazine hydrochloride	121274	25.00g	$192
4-(Sulfamoylphenyl) hydrazine hydrochloride	121274	250.00g	$960
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4-Hydrazinobenzene-1-sulfonamide hydrochloride Properties

Melting point	149-152 °C(lit.)
Density	1.644[at 20℃]
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Methanol (Slightly, Heated), Water (Slightly)
form	powder to crystal
color	White to Light yellow to Light orange
Water Solubility	Soluble in water.
Sensitive	Hygroscopic
Major Application	pharmaceutical (small molecule)
InChI	InChI=1S/C6H9N3O2S.ClH/c7-9-5-1-3-6(4-2-5)12(8,10)11;/h1-4,9H,7H2,(H2,8,10,11);1H
InChIKey	IKEURONJLPUALY-UHFFFAOYSA-N
SMILES	C1(S(=O)(=O)N)C=CC(NN)=CC=1.Cl
LogP	-0.99 at 20℃
CAS DataBase Reference	17852-52-7(CAS DataBase Reference)
FDA UNII	9D634JG95C
EPA Substance Registry System	Benzenesulfonamide, 4-hydrazinyl-, hydrochloride (1:1) (17852-52-7)
UNSPSC Code	12352200
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38

Safety Statements

36-24/25

WGK Germany

RTECS

DA9380000

Hazard Note

Irritant

HS Code

29350090

REACH Registrations

Active

NFPA 704

	1
0		0

4-Hydrazinobenzene-1-sulfonamide hydrochloride price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS003887	4-sulfonamidophenylhydrazine hydrochloride AldrichCPR	17852-52-7	250mg	$81.6	2023-01-07	Buy
TCI Chemical	H1230	4-Hydrazinobenzenesulfonamide Hydrochloride >98.0%(HPLC)(T)	17852-52-7	5g	$28	2026-04-30	Buy
TCI Chemical	H1230	4-Hydrazinobenzenesulfonamide Hydrochloride >98.0%(HPLC)(T)	17852-52-7	25g	$86	2026-04-30	Buy
Matrix Scientific	121274	4-(Sulfamoylphenyl) hydrazine hydrochloride	17852-52-7	25.00g	$192	2026-05-18	Buy
Matrix Scientific	121274	4-(Sulfamoylphenyl) hydrazine hydrochloride	17852-52-7	250.00g	$960	2026-05-18	Buy

Product number	Packaging	Price	Buy
CDS003887	250mg	$81.6	Buy
H1230	5g	$28	Buy
H1230	25g	$86	Buy
121274	25.00g	$192	Buy
121274	250.00g	$960	Buy

4-Hydrazinobenzene-1-sulfonamide hydrochloride Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

Intermediate in the production of Celebrex.

Uses

It is a potentially useful intermediate in the production of Celebrex an anti inflammatory drug.

Flammability and Explosibility

Non flammable

Synthesis

63-74-1

4-Hydrazinobenzene-1-sulfonamide hydrochloride

17852-52-7

The general procedure for the synthesis of p-hydrazinylbenzenesulfonamide hydrochloride from crystalline sulfanilamide was as follows: firstly, 4'-methylacetophenone was reacted with succinic anhydride in the presence of diisopropanolamine (LDA) and tetrahydrofuran (THF) for 1 hr at -78 °C to afford p-tolyl-4,6-dioxohexanoic acid in 66% yield and the product was a white solid. Subsequently, the sulfonamide was reacted with sodium nitrite (NaNO2) and concentrated hydrochloric acid for 30 min at 0-4 °C, followed by the addition of tin(II) chloride (SnCl2), and the reaction was continued for 4 h at 0 °C to produce 4-sulfonylaminophenylhydrazine hydrochloride in 55% yield, the product being a pale yellow solid. Finally, p-tolyl-4,6-dioxohexanoic acid was reacted with 4-sulfonylaminophenylhydrazine hydrochloride in a methanolic solution of triethanolamine (TEA) at room temperature for 16 h to give compound 30c, 3-[1-{p-(p-(sulfonylamino)phenyl}-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid in 76% yield and the product was a yellow solid.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 18, p. 4444 - 4452
[2] Organic Letters, 2012, vol. 14, # 19, p. 5030 - 5033,4
[3] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 4, p. 913 - 922
[4] Patent: US2007/292352, 2007, A1. Location in patent: Page/Page column 45-46
[5] Patent: US2003/236294, 2003, A1. Location in patent: Page 9

4-Hydrazinobenzene-1-sulfonamide hydrochloride Preparation Products And Raw materials

Raw materials

Sulfanilamide Sodium nitrite Hydrochloric acid

Preparation Products

4-Hydrazinobenzene-1-sulfonamide hydrochloride Suppliers

Global( 580)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2988	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58

View Lastest Price from 4-Hydrazinobenzene-1-sulfonamide hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-27	4-Hydrazinobenzene-1-sulfonamide hydrochloride 17852-52-7			0.99		RongNa Biotechnology Co.,Ltd
2026-03-20	4-Hydrazinobenzene-1-sulfonamide hydrochloride 17852-52-7	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	4-Hydrazinobenzene-1-sulfonamide hydrochloride 17852-52-7	US $10.00-0.80 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

4-Hydrazinobenzene-1-sulfonamide hydrochloride
17852-52-7
0.99
RongNa Biotechnology Co.,Ltd

4-Hydrazinobenzene-1-sulfonamide hydrochloride
17852-52-7
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Hydrazinobenzene-1-sulfonamide hydrochloride
17852-52-7
US $10.00-0.80 / KG
99%
Henan Fengda Chemical Co., Ltd

4-Hydrazinobenzene-1-sulfonamide hydrochloride Spectrum

4-Hydrazinobenzene-1-sulfonamide hydrochloride(17852-52-7)MS 4-Hydrazinobenzene-1-sulfonamide hydrochloride(17852-52-7)¹HNMR 4-Hydrazinobenzene-1-sulfonamide hydrochloride(17852-52-7)IR1 4-Hydrazinobenzene-1-sulfonamide hydrochloride(17852-52-7)IR2

17852-52-7(4-Hydrazinobenzene-1-sulfonamide hydrochloride)Related Search:

Hydrazine monohydrochloride Benzenesulfonamide Benzoyl hydrazine Topotecan hydrochloride 4-Methylbenzenesulfonhydrazide

1,5-Diphenylcarbazide Phenylhydrazine hydrochloride 4-AMINOAZOBENZENE HYDROCHLORIDE D-Glucosamine hydrochloride Celecoxib Trifluro Impurity

5-(TRIFLUOROMETHYL)-3-P-TOLYL-1H-PYRAZOLE 4-[5-hydroxy-3-(4-methylphenyl)-5-(trifluoromethyl)-4H-pyrazol-1-yl]benzenesulfonamide Celecoxib Impurity 6 Celecoxib iMpurity-G Celecoxib IMpurity 1

Celecoxib Impurity 2 Sulfanilamide Celecoxib Impurity

1of4

4-SPH 4-Sulphamoylphenylhydrazine hydrochloride, 4-(Aminosulphonyl)phenylhydrazine hydrochloride p-Sulfonamidophenylhydrazine 4-Hydrazinobenzene-1 4-Aminosulfonylphenylhydrazine hydrochloride 4-Hydrazinobenzene-1-sulfonamide hydrochloride 4-Sulfonamidophenylhydrazine hydrochloride 4-SAPH.HCl Celecoxib Impurity 10 HCl p-Sulfonamidophenylhydrazine HCl 4-Hydrazinobenzene-1-sulfonaMide Deracoxib Impurity 3 (E)-4-(2-(1-(o-tolyl)ethylidene)hydrazinyl)benzenesulfonamide Celecoxib Intermediate 4-Hydrazinobenzenesulphonamide hydrochloride 99% Celecoxib Hydrazine Impurity Celecoxib Impurity HCl (4-Hydrazinobenzene-1-sulfonamide HCl) 4-(sulfaMoylphenyl)hydrazine Monohydrochloride 4-Hydrazine benzene sulfonaMide hydrochloride 4-AMinosulfonylphenylhydrazine HCl Hydrazine benzene sulfonamide hydrochloride Thehydrazinebenzene sulfonaMidehydrochloride 4-Hydrazinobenzene-1-sulfonamide hydrochloride (Celecoxib) BENZENESULFONYLAMIDE BENZENESULPHONAMIDE 4-HYDRAZINOBENZENE-1-SULFONAMIDE HCL Celecoxib hydrochloride impurities (4-hydrazinophenyl-1-sulfonamide hydrochloride) 4-HydrazinobenzenesulfonamideHydrochloride> Celecoxib Impurity HCl fonamide HydrochL Benzenesulfonamide, 4-hydrazinyl-, hydrochloride (1:1) 4- hydrazine-benzene-1-sulfonamide hydrochloride 4-Hydrazinobenzene-1-sulfonamide hydrochloride ISO 9001：2015 REACH 4-Hydrazinobenzene-1-Sulfonamide Hydrochloride4-Hydrazinobenzene-1-Sulfonamide Hydrochloride 4-Hydrazinobenzene-1-Sulfonamide Hydrochloride 4-Hydrarazinobenzene sulfonamide Hydrochloride 4-Sulphanamido Phenyl Hydrazine Hydrochloride 4-Sulphanamido Phenyl Hydrazine Hydrochloride (4-SAPH) 4-sulphanamido phenyl hydrazine Hydrochloride (4-SPH) 4-Sulphonamido Phenyl Hydrazine Hydrochloride(4-SPH) 4-Sulfonamido Phenyl Hydrazine Hydrochloride (4SPH HCL) OR 4-Hydrazinobenzenesulfonamide HCL 4-sulphanamido phenyl hydrazine HCL (4-SPH) 4-Hydrazinyl-1-Sulfonamide—Hydrogen Chloride 4-SPH/Sulfonamide 4-Hydrazino Benzene Sulfonamide HCI 4-Hydrazinylbenzen-1-Sulfonamide-Hydrogen Chloride 4-Suphonamido Phenyl Hydrazine HCL Celecoxib Impurity 21 HCl Acrylamide Impurity 4 Sulfonamide benzyl chloride 4-hydrazylbenzene sulfonamide hydrochloride Celecoxib Hydrazine Impurity 4-Sulphonamido phenyl hydrazine hydrochloride Celecoxib Impurity 36 Hydrochloride (4-Sulfamoylpheny)hydrazine monohydrochloride p-Hydrazinobenzenesulfonamide hydrochloride (4-SAPH) Sulfonamide phenyl hydrazine hydrochloride p-Sulfamoylphenylhydrazine hydrochloride 4-SULPHONAMIDO PHENYL HYDRAZINE HCL(4-SPH)