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1-Methyl-5-nitro-1H-indole

1-Methyl-5-nitro-1H-indole structure

CAS No.: 29906-67-0

Chemical Name:: 1-Methyl-5-nitro-1H-indole

Synonyms: 1-Methyl-5-Nitroindole;1-Methyl-5-nitro-1H-indole;1H-Indole, 1-Methyl-5-nitro-;1-Methyl-5-nitro-1H-indole ,97%

CBNumber:: CB1207231

Molecular Formula:: C9H8N2O2

Molecular Weight:: 176.17

MDL Number:: MFCD07772841

MOL File:: 29906-67-0.mol

MSDS File:: SDS

Last updated:2026-09-12 18:49:01

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1-Methyl-5-nitro-1H-indole Properties

Melting point	167 °C
Boiling point	339.2±15.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly)
form	Solid
color	Dark Yellow to Very Dark Yellow
InChI	InChI=1S/C9H8N2O2/c1-10-5-4-7-6-8(11(12)13)2-3-9(7)10/h2-6H,1H3
InChIKey	PXBQSCHRKSBGKV-UHFFFAOYSA-N
SMILES	N1(C)C2=C(C=C([N+]([O-])=O)C=C2)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P271-P280-P260

Risk Statements

22-41

Safety Statements

26-39

HazardClass

IRRITANT

HS Code

29349990

NFPA 704

	1
2		0

1-Methyl-5-nitro-1H-indole price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-M320970-5G	1-Methyl-5-nitro-1H-indole	29906-67-0	5g	$177	2026-06-03	Buy
TRC	TRC-M320970-25G	1-Methyl-5-nitro-1H-indole	29906-67-0	25g	$504	2026-06-03	Buy
TRC	TRC-M320970-1G	1-Methyl-5-nitro-1H-indole	29906-67-0	1g	$91	2026-06-03	Buy
Apolloscientific	OR70135	1-Methyl-5-nitro-1H-indole ≥95%	29906-67-0	1g	$21	2026-06-04	Buy
Apolloscientific	OR70135	1-Methyl-5-nitro-1H-indole ≥95%	29906-67-0	5g	$47	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-M320970-5G	5g	$177	Buy
TRC-M320970-25G	25g	$504	Buy
TRC-M320970-1G	1g	$91	Buy
OR70135	1g	$21	Buy
OR70135	5g	$47	Buy

1-Methyl-5-nitro-1H-indole Chemical Properties, Uses, Production

Chemical Properties

Light yellow solid

Uses

1-Methyl-5-nitro-1H-indole is used as a reagent in the synthesis of the antiasthmatic drug Zafirlukast (Z125000).

Synthesis

6146-52-7

616-38-6

29906-67-0

91482-63-2

Example 14 Synthesis of 1-methyl-5-nitroindole. To a 500 mL three-necked flask equipped with a thermocouple, condenser tube, and constant pressure dropping funnel was added 5-nitroindole (20.0 g, 123 mmol), potassium carbonate (4.0 g, 29 mmol), N,N-dimethylformamide (80 mL), and dimethyl carbonate (22 mL, 261.4 mmol). The reaction mixture was heated to reflux. The reaction progress was monitored by high performance liquid chromatography (HPLC) or thin layer chromatography (TLC) (unfolding agent: heptane solution of 30% ethyl acetate). After 3 hours of refluxing, complete conversion of 5-nitroindole was confirmed by the analytical method described above. The reaction mixture was then cooled to 10±5°C and diluted with water (160 mL), at which point a yellow precipitate was generated. The mixture was continued to be stirred at room temperature for 2 h, after which the solid product was collected by filtration, washed with water (100 mL), and finally dried under high vacuum at 60-65 °C for 24 h. 1-methyl-5-nitroindole (21.1 g, 97.1% yield) was obtained as a yellow solid.

References

[1] Patent: US6326501, 2001, B1

1-Methyl-5-nitro-1H-indole Preparation Products And Raw materials

Raw materials

5-Nitroindole Quinoline Ethanol Potassium hydroxide Acetone

Ethyl pyruvate polyphosphoric acid Cupric oxide 4-Nitrophenylhydrazine Dichloromethane

Iodomethane

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Preparation Products

1H-Indol-5-amine, 1-methyl-N-2-propen-1-yl-

1-Methyl-5-nitro-1H-indole Suppliers

Global Suppliers ( 163)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Alan Pharmaceutical Co., LTD	021-58099609-8008 13816260319	251218799@qq.com	China	500	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6742	52
Shanghai Ennopharm Co., Ltd.	+86 (21) 6435-5022		China	4263	65
Tongchuang Pharma(Suzhou). Co., Ltd.	0512-63263366 18912765016	tongtf110@sina.com	China	984	62

Supplier	Advantage
Shanghai Alan Pharmaceutical Co., LTD	58
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Adamas Reagent, Ltd.	59
Shanghai Longsheng chemical Co.,Ltd.	59
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
XiaoGan ShenYuan ChemPharm co,ltd	52
Shanghai Ennopharm Co., Ltd.	65
Tongchuang Pharma(Suzhou). Co., Ltd.	62

View Latest Price from 1-Methyl-5-nitro-1H-indole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-06-30	1-METHYL-5-NITRO-1H-INDOLE 29906-67-0		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
	2019-07-06	1-METHYL-5-NITRO-1H-INDOLE 29906-67-0	$1.00	1G	98%	100KG	Career Henan Chemical Co

1-METHYL-5-NITRO-1H-INDOLE
29906-67-0
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

1-METHYL-5-NITRO-1H-INDOLE
29906-67-0
$1.00
98%
Career Henan Chemical Co

1-Methyl-5-nitro-1H-indole Spectrum

1-METHYL-5-NITRO-1H-INDOLE(29906-67-0)¹HNMR

29906-67-0 (1-Methyl-5-nitro-1H-indole) Related Search:

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1-Methyl-5-nitro-1H-indole ,97% 1H-Indole, 1-Methyl-5-nitro- 1-Methyl-5-Nitroindole 1-Methyl-5-nitro-1H-indole 29906-67-0 Heterocycle-Indole series