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2-Bromo-6-methoxypyridine

CAS No.
40473-07-2
Chemical Name:
2-Bromo-6-methoxypyridine
Synonyms
6-BroMo-2-Methoxypyridine;NSC 84173;2-BROMO-6-METHOXYPYRIDINE;2-Methoxy-6-broMopyridine;2-BROMO-6-METHOXYPYRIMIDINE;Pyridine, 2-broMo-6-Methoxy-;2-Bromo-6-(methyloxy)pyridine;2-Bromo-6-methoxypyridine >2-BROMO-6-METHOXY-PYRIDINE 98%;2-Bromo-6-methoxypyridine ,98%
CBNumber:
CB1210598
Molecular Formula:
C6H6BrNO
Molecular Weight:
188.02
MDL Number:
MFCD00088345
MOL File:
40473-07-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:14:19
Product description Number Pack Size Price
2-Bromo-6-methoxypyridine 97% 520535 5ml $101
2-Bromo-6-methoxypyridine >97.0%(GC) B3260 5g $32
2-Bromo-6-methoxypyridine >97.0%(GC) B3260 25g $127
2-Bromo-6-methoxypyridine Asreported 266380 10g $333
2-Bromo-6-methoxypyridine Asreported 266380 25g $513
More product size

2-Bromo-6-methoxypyridine Properties

Boiling point 206 °C (lit.)
Density 1.53 g/mL at 25 °C (lit.)
refractive index n20/D 1.559(lit.)
Flash point 220 °F
storage temp. Inert atmosphere,Room Temperature
pka -1.04±0.10(Predicted)
form Liquid
color Clear colorless to golden
InChI InChI=1S/C6H6BrNO/c1-9-6-4-2-3-5(7)8-6/h2-4H,1H3
InChIKey KMODISUYWZPVGV-UHFFFAOYSA-N
SMILES C1(Br)=NC(OC)=CC=C1
CAS DataBase Reference 40473-07-2(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,T,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333990
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Bromo-6-methoxypyridine price More Price(81)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 520535 2-Bromo-6-methoxypyridine 97% 40473-07-2 5ml $101 2026-04-30 Buy
TCI Chemical B3260 2-Bromo-6-methoxypyridine >97.0%(GC) 40473-07-2 5g $32 2026-04-30 Buy
TCI Chemical B3260 2-Bromo-6-methoxypyridine >97.0%(GC) 40473-07-2 25g $127 2026-04-30 Buy
Usbiological 266380 2-Bromo-6-methoxypyridine Asreported 40473-07-2 10g $333 2026-06-03 Buy
Usbiological 266380 2-Bromo-6-methoxypyridine Asreported 40473-07-2 25g $513 2026-06-03 Buy
Product number Packaging Price Buy
520535 5ml $101 Buy
B3260 5g $32 Buy
B3260 25g $127 Buy
266380 10g $333 Buy
266380 25g $513 Buy

2-Bromo-6-methoxypyridine Chemical Properties,Uses,Production

Chemical Properties

Light yellow liquid

Uses

The commercial 2-Bromo-6-methoxypyridine could be used as a starting material to synthesize cyclopenta[b]pyridin-2,5-dione. The overall route consists of a first sequence of regioselective ortho lithiation and methoxycarbonylation followed by Heck vinylation, alkene reduction, cyclization, and decarboxylation[1].

Synthesis

2,6-Dibromopyridine

626-05-1

Sodium Methoxide

124-41-4

2-Bromo-6-methoxypyridine

40473-07-2

Under argon protection, sodium methanol (1.82 g) was slowly added to a solution of toluene (120 mL) containing 2,6-dibromopyridine (8.0 g), followed by continuous stirring at 120 °C for 13 hours. During the reaction, sodium methanol (0.728 g) was added supplementally and stirring was continued at the same temperature for 6 hours. Upon completion of the reaction, the mixture was naturally cooled to room temperature. The reaction mixture was transferred to a dispensing funnel and partitioned by adding water and ethyl acetate. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the solvent was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate gradient) to afford 2-bromo-6-methoxypyridine as an oil (5.64 g, 89% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 3.93 (3H, s, OCH3), 6.68 (1H, d, J = 8.0 Hz, Ar-H), 7.05 (1H, d, J = 7.2 Hz, Ar-H), 7.39-7.42 (1H, m, Ar-H).

References

[1] Robert, Nicolas , et al. "A convenient synthesis of cyclopenta[b]pyridin-2,5-dione as a non- glycosidic cardiotonic agent." ARKIVOC 2008.7(2008):92-100.

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View Lastest Price from 2-Bromo-6-methoxypyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-6-methoxypyridine pictures 2026-03-20 2-Bromo-6-methoxypyridine
40473-07-2
$9.80 1KG 99% 10 tons Hebei Chuanghai Biotechnology Co., Ltd
2-Bromo-6-methoxypyridine  pictures 2025-11-18 2-Bromo-6-methoxypyridine
40473-07-2
$1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
	2-Bromo-6-methoxypyridine pictures 2025-09-25 2-Bromo-6-methoxypyridine
40473-07-2
$5.00 1KG 98% Henan Fengda Chemical Co., Ltd

2-Bromo-6-methoxypyridine Spectrum

2-Bromo-6-methoxypyridine ,98% 2-Bromo-6-methoxy-pyridine ,97% 2-Bromo-6-methoxypyrimidine ,98% Pyridine, 2-broMo-6-Methoxy- 2-Methoxy-6-broMopyridine NSC 84173 2-Bromo-6-(methyloxy)pyridine 2-BROMO-6-METHOXYPYRIDINE 2-BROMO-6-METHOXYPYRIMIDINE 2-BROMO-6-METHOXY-PYRIDINE 98% 2-Bromo-6-methoxypyridine > 2-Bromo-6-methoxypyridine ISO 9001:2015 REACH 6-BroMo-2-Methoxypyridine 40473-07-2 40473-07-3 40474-07-2 Building Blocks Pyridines Heterocyclic Building Blocks Halogenated Heterocycles C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Heterocycle-Pyridine series alkyl bromide blocks Bromides Pyridines Heterocyclic Series Halides Pyridine compounds of pyridine