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Methyl 2-aminopyridine-4-carboxylate

Methyl 2-aminopyridine-4-carboxylate structure

CAS No.: 6937-03-7

Chemical Name:: Methyl 2-aminopyridine-4-carboxylate

Synonyms: METHYL 2-AMINOISONICOTINATE;2-Aminopyridine-4-carboxylic acid methyl ester;NSC 40138;Methyl 2-aMinopy;CHEMBRDG-BB 4015127;2-aminopyridine-4-carboxyL;2- aMinoMethyl isonicotinate;Methyl2-Aminoisonicotinate>Methyl 2-aminoisonicotinate 98%;Methyl 2-aminoisonicotinate, 98%

CBNumber:: CB1212183

Molecular Formula:: C7H8N2O2

Molecular Weight:: 152.15

MDL Number:: MFCD04039316

MOL File:: 6937-03-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:14:28

Product description	Number	Pack Size	Price
Methyl 2-aminopyridine-4-carboxylate 97%	704482	1g	$76.3
Methyl 2-aminopyridine-4-carboxylate 97%	704482	5G	$137
Methyl 2-Aminoisonicotinate >98.0%(GC)(T)	M2172	1g	$19
Methyl 2-Aminoisonicotinate >98.0%(GC)(T)	M2172	5g	$59
Methyl 2-Aminoisonicotinate	016497	2.5g	$418
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Methyl 2-aminopyridine-4-carboxylate Properties

Melting point	144-148 °C
Boiling point	296.1±20.0 °C(Predicted)
Density	1.238±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform
pka	4.89±0.11(Predicted)
form	Crystalline Powder
color	White to brown
Water Solubility	Insoluble in water.
BRN	128642
InChI	InChI=1S/C7H8N2O2/c1-11-7(10)5-2-3-9-6(8)4-5/h2-4H,1H3,(H2,8,9)
InChIKey	SVWWNEYBEFASMP-UHFFFAOYSA-N
SMILES	C1(N)=NC=CC(C(OC)=O)=C1
CAS DataBase Reference	6937-03-7(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

P280-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38-41-20/22

Safety Statements

26-36-26/36-39-36/37/39-22

WGK Germany

WGK 2

HazardClass

IRRITANT

HS Code

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Dam. 1

NFPA 704

	1
2		0

Methyl 2-aminopyridine-4-carboxylate price More Price(90)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	704482	Methyl 2-aminopyridine-4-carboxylate 97%	6937-03-7	1g	$76.3	2023-06-20	Buy
Sigma-Aldrich	704482	Methyl 2-aminopyridine-4-carboxylate 97%	6937-03-7	5G	$137	2023-06-20	Buy
TCI Chemical	M2172	Methyl 2-Aminoisonicotinate >98.0%(GC)(T)	6937-03-7	1g	$19	2026-04-30	Buy
TCI Chemical	M2172	Methyl 2-Aminoisonicotinate >98.0%(GC)(T)	6937-03-7	5g	$59	2026-04-30	Buy
Usbiological	016497	Methyl 2-Aminoisonicotinate	6937-03-7	2.5g	$418	2026-06-03	Buy

Product number	Packaging	Price	Buy
704482	1g	$76.3	Buy
704482	5G	$137	Buy
M2172	1g	$19	Buy
M2172	5g	$59	Buy
016497	2.5g	$418	Buy

Methyl 2-aminopyridine-4-carboxylate Chemical Properties,Uses,Production

Chemical Properties

Tan Solid

Uses

Methyl 2-aminopyridine-4-carboxylate is an inhibitor of nitrogen monoxide synthetase.

Uses

A nitrogen monoxide synthetase inhibitor.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

Synthesis

67-56-1

13362-28-2

6937-03-7

The general procedure for the synthesis of methyl 2-aminoisonicotinate from methanol and 2-aminoisonicotinic acid was as follows: 2-aminoisonicotinic acid (207 g, 1.5 mol) was dissolved in methanol (1.8 L) to prepare a solution. The solution was slowly added dropwise to thionyl chloride (238 g, 2 mol) at 50 °C. After the dropwise addition was completed, the reaction temperature was maintained at 50 °C and the reaction mixture continued to be stirred for 5 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, saturated aqueous sodium carbonate solution was added and the pH was adjusted to 9-10 to make the reaction mixture basic. Subsequently, the mixed solution was extracted with dichloromethane (300 ml each time for 3 times). The organic layers were combined and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration to give methyl 2-aminoisonicotinate (189 g, 83% yield) as a yellow solid. The structure of the product was confirmed by 1H-NMR (d6-DMSO, 300 MHz): δ 3.96 (s, 3H); 7.14 (d, 1H); 7.49 (br, 1H); 8.07 (d, 1H); 8.18 (br, 2H, NH).

References

[1] European Journal of Medicinal Chemistry, 2013, vol. 61, p. 26 - 40
[2] Journal of the American Chemical Society, 2018, vol. 140, # 9, p. 3322 - 3330
[3] Chemistry - A European Journal, 2012, vol. 18, # 27, p. 8498 - 8507
[4] Patent: EP3018125, 2016, A1. Location in patent: Paragraph 0515-0518
[5] Russian Journal of Organic Chemistry, 2015, vol. 51, # 5, p. 744 - 745

Methyl 2-aminopyridine-4-carboxylate synthesis

Synthesis of Methyl 2-aminopyridine-4-carboxylate from 4-Methylpyridin-2-amine and Methanol

Methyl 2-aminopyridine-4-carboxylate Preparation Products And Raw materials

Raw materials

Methanol Chloroacetaldehyde 4-Methylpyridin-2-amine Methyl 2-amino-5-bromo-4-pyridinecarboxylate 2-Aminoisonicotinic acid

Preparation Products

TERT-BUTYL 4-(HYDROXYMETHYL)PYRIDIN-2-YLCARBAMATE TERT-BUTYL 4-(AMINOMETHYL)PYRIDIN-2-YLCARBAMATE (2-TERT-BUTOXYFORMAMIDO-PYRIDIN-4-YL)METHYL METHANESULFONATE TERT-BUTYL 4-(METHOXYCARBONYL)PYRIDIN-2-YLCARBAMATE Methyl 2-aMino-5-chloropyridine-4-carboxylate

2-(2-Amino-4-pyridyl)-2-propanol 1-(2-AMINO-PYRIDIN-4-YL)-ETHANONE 2-PHENYL-IMIDAZO[1,2-A]PYRIDINE-7-CARBOXYLIC ACID METHYL ESTER

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Methyl 2-aminopyridine-4-carboxylate Suppliers

Global( 254)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3970	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58

View Lastest Price from Methyl 2-aminopyridine-4-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	Methyl 2-aminopyridine-4-carboxylate 6937-03-7		1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-01	Methyl 2-aminopyridine-4-carboxylate 6937-03-7		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-11-18	Methyl 2-aminopyridine-4-carboxylate 6937-03-7	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

Methyl 2-aminopyridine-4-carboxylate
6937-03-7
$0.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Methyl 2-aminopyridine-4-carboxylate
6937-03-7
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

Methyl 2-aminopyridine-4-carboxylate
6937-03-7
$1.10
99.00%
Dideu Industries Group Limited

Methyl 2-aminopyridine-4-carboxylate Spectrum

Methyl 2-aminopyridine-4-carboxylate(6937-03-7)¹HNMR Methyl 2-aminopyridine-4-carboxylate(6937-03-7)FT-IR

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METHYL 2-AMINOPYRIDINE-4-CARBOXYLATE CHEMBRDG-BB 4015127 2-Aminopyridinecarboxylic acid methyl ester~Methyl 2-aminoisonicotinate 2-Aminopyridine-4-carboxylic acid methyl ester 2-aminopyridinecarboxylic acid methyl ester 2-amino-3-methyl-4-pyridinecarboxylate Methyl 2-aminoisonicotinate 98% 2-Amniopyridine-4-carboxylic acid methyl ester methyl 2-aminoisonicotinate(SALTDATA: FREE) Methyl 2-aminopyridine-4-carboxylate, 4-(Methoxycarbonyl)pyridin-2-amine methyl 2-aminoisonicotinate, (2-Amino-4-pyridinecarboxylic acid methylester) Methyl 2-Amino-4-pyridinecarboxylate NSC 40138 2-Aminoisonicotinic Acid Methyl Ester Methyl 2-Aminopyridine-4-carboxylate 2-Aminopyridine-4-carboxylic Acid Methyl Ester Methyl 2-aMinoisonicotinate-CAS6937-03-7 Methyl 2-aMinopy 2- aMinoMethyl isonicotinate Methyl 2-aMinopyridine-4-carboxylate, >95% 4-Pyridinecarboxylic acid, 2-amino-, methyl ester Methyle2-aminopyridine-4-carboxylate Methyl2-Aminoisonicotinate> 2-aminopyridine-4-carboxyL Methyl 2-aminopyridine-4-carboxylate ISO 9001：2015 REACH 4-Pyridinecarboxylic acid, 2-amino-, methyl ester (9CI, ACI) 2-amino-4-Pyridinecarboxylic acid methyl ester (9CI ACI) Methyl 2-aminoisonicotinate, 98% Methyl 2-aminoisopyridin-3-carboxylate METHYL 2-AMINOISONICOTINATE 6937-03-7 1839794 6837-03-7 Amines Heterocycles Inhibitors Esters Pyridines Pyridine API intermediates Heterocycle-Pyridine series