BCTC
- CAS No.
- 393514-24-4
- Chemical Name:
- BCTC
- Synonyms
- BCTC;BCTC, 10 mM in DMSO;BCTC, inhibitor of TRPV1;N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide;1-Piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-diMethylethyl)phenyl]-1-piperazinecarboxaMide (BCTC)
- CBNumber:
- CB12122071
- Molecular Formula:
- C20H25ClN4O
- Molecular Weight:
- 372.89
- MDL Number:
- MFCD08690556
- MOL File:
- 393514-24-4.mol
- MSDS File:
- SDS
| Melting point | 150-152℃ |
|---|---|
| Boiling point | 561.6±50.0 °C(Predicted) |
| Density | 1.229±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: >10mg/mL |
| pka | 13.95±0.70(Predicted) |
| form | powder |
| color | white to beige |
| Sensitive | Light Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stord at -20°C for up to 2 months. |
| InChIKey | ROGUAPYLUCHQGK-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264b-P270-P301+P312-P330-P403-P501c | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
BCTC price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0355 | BCTC ≥98% (HPLC) | 393514-24-4 | 5mg | $96.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0355 | BCTC ≥98% (HPLC) | 393514-24-4 | 25mg | $314 | 2024-03-01 | Buy |
| Alfa Aesar | J67361 | BCTC, 98% | 393514-24-4 | 50mg | $507 | 2021-12-16 | Buy |
| Alfa Aesar | J67361 | BCTC, 98% | 393514-24-4 | 10mg | $172 | 2021-12-16 | Buy |
| Cayman Chemical | 10006309 | BCTC ≥98% | 393514-24-4 | 5mg | $41 | 2024-03-01 | Buy |
BCTC Chemical Properties,Uses,Production
Description
BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) blocker, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. BCTC is orally active and cell permeable.
Uses
BCTC is a antagonists of TRPA1 and TRPV1, a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons. BCTC inhibits both capsaicin and proton activation.
Definition
ChEBI: 1-piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-n-[4-(1,1-dimethylethyl)phenyl]- is a member of piperazines and a member of pyridines.
in vivo
BCTC (1-30 mg/kg; Oral gavage; Single dose) can inhibit inflammatory and neuropathic heat pain and mechanical hyperalgesia in Sprague-Dawley rats by targeting VR1, which has analgesic effect[2].
BCTC (10-100 mg/kg; Oral gavage, Twice daily for 4 weeks) improves the insulin resistance and systemic glucose and lipid metabolism, and increase insulin secretion in diabetic ob/ob mice[5].
| Animal Model: | Capsaicin-induced Sprague-Dawley rats model[2] |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg |
| Administration: | Oral gavage (p.o.), Single dose. Before capsaicin (HY-10448) treatment (30 μg; intraplantar injection; Single dose) |
| Result: | Inhibited capsaicin-mediated thermal hyperalgesia in a dose-dependent manner. |
| Animal Model: | Freund’s complete adjuvant (FCA) Sprague-Dawley rats model[2] |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg |
| Administration: | Oral gavage (p.o.), Single dose. After 100 % FAC treatment (50 μL; intraplantar injection; Single dose) |
| Result: | Significantly reduced FAC-induced inflammation-related thermal pain and mechanical hyperalgesia, and extended the inhibitory effect of mechanical hyperalgesia to 6 h at high doses (10 mg/kg, 30 mg/kg). |
| Animal Model: | Partial sciatic nerve ligation Sprague-Dawley rats model[2] |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg |
| Administration: | Oral gavage (p.o.), Single dose. After partial sciatic nerve ligation. |
| Result: | Reduced post-operative abnormal tactile pain and mechanical hyperalgesia in a dose-dependent manner. |
| Animal Model: | Particularly strong insulin resistance and hyperinsulinemia ob/ob mice model[5] |
| Dosage: | 10 mg/kg, 30 mg/kg, 100 mg/kg |
| Administration: | Oral gavage (p.o.); Twice daily for 4 weeks |
| Result: | Reduced plasma triglyceride and glucose area under the curve (AUC) level. Decreased calcitonin gene-related peptide (CGRP) levels in a dose-dependent manner. |
storage
Room temperature
References
1) Valenzano et al. (2003), N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties; J. Pharmacol. Exp. Ther., 306 377 2) Pomonis et al. (2003), N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain; J. Pharmacol. Exp. Ther., 306 387
BCTC Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49980 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
