6-Bromo-4-iodoquinoline
- CAS No.
- 927801-23-8
- Chemical Name:
- 6-Bromo-4-iodoquinoline
- Synonyms
- 6-Bromo-4-iodoquinoline;4-Iodo-6-bromoquinoline;Quinoline, 6-bromo-4-iodo-;6-Bromo-4-iodoquinoline 97%
- CBNumber:
- CB1222641
- Molecular Formula:
- C9H5BrIN
- Molecular Weight:
- 333.95
- MDL Number:
- MFCD08437008
- MOL File:
- Mol file
- MSDS File:
- SDS
| Boiling point | 375.5±22.0 °C(Predicted) |
|---|---|
| Density | 2.154±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | solid |
| pka | 2.77±0.16(Predicted) |
| color | Brown |
| InChI | InChI=1S/C9H5BrIN/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-5H |
| InChIKey | BWFLFNVNIISPPK-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC(Br)=CC=2)C(I)=CC=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 2933491090 |
6-Bromo-4-iodoquinoline price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR927338 | 6-Bromo-4-iodoquinoline 97% | 927801-23-8 | 250mg | $32 | 2026-06-04 | Buy |
| Apolloscientific | OR927338 | 6-Bromo-4-iodoquinoline 97% | 927801-23-8 | 1g | $98 | 2026-06-04 | Buy |
| Apolloscientific | OR927338 | 6-Bromo-4-iodoquinoline 97% | 927801-23-8 | 5g | $408 | 2026-06-04 | Buy |
| Activate Scientific | AS16188 | 6-Bromo-4-iodoquinoline 97% | 927801-23-8 | 1g | $76 | 2026-06-04 | Buy |
| Activate Scientific | AS16188 | 6-Bromo-4-iodoquinoline 97% | 927801-23-8 | 5g | $199 | 2026-06-04 | Buy |
6-Bromo-4-iodoquinoline Chemical Properties, Uses, Production
Synthesis
1086062-75-0
927801-23-8
4.1.9 Synthesis of 6-bromo-4-iodoquinoline (12): To an anhydrous ethyl acetate (20 mL) solution of 6-bromo-4-chloroquinoline (11) (3.50 g, 14.46 mmol) was added hydrochloric acid saturated ethyl acetate (40 mL), and the formation of a white precipitate was immediately observed. After stirring for 30 min, the suspension was concentrated under vacuum to give 6-bromo-4-chloroquinoline hydrochloride as an off-white solid (3.91 g, 14.14 mmol). Subsequently, 6-bromo-4-chloroquinoline hydrochloride (3.91 g, 14.14 mmol), anhydrous potassium iodide (9.76 g, 70.70 mmol), and anhydrous acetonitrile (100 mL) were added in a two-neck flask. The resulting slurry was stirred under reflux conditions for 48 hours and then cooled to room temperature. The reaction mixture was treated with saturated aqueous sodium bicarbonate solution (40 mL) and 5% sodium sulfite solution (20 mL). The reaction mixture was extracted with dichloromethane (200 mL x 2), and the combined organic phases were dried over magnesium sulfate and concentrated under vacuum to give the crude product. The crude product was further purified by silica gel column chromatography (25% ethyl acetate/petroleum ether) to afford the target compound 6-bromo-4-iodoquinoline (4.42 g, 13.27 mmol, 94% yield) as an off-white solid. 1H NMR (500 MHz, DMSO-d6) δ 8.51 (d, J = 4.5 Hz, 1H, Ar-H), 8.21 (d, J = 4.5 Hz, 1H, Ar-H), 8.11 (t, J = 1.5 Hz, 1H, Ar-H), 7.97-7.91 (m, 2H, Ar-H). ESI-MS: m/z = 334 [M + H]+.
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 99, p. 36 - 50
[2] RSC Advances, 2017, vol. 7, # 4, p. 2342 - 2350
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1569 - 1574
[4] Patent: WO2014/22128, 2014, A1. Location in patent: Paragraph 0156; 0157
[5] Patent: CN103539777, 2016, B. Location in patent: Paragraph 0276; 0327; 0328
6-Bromo-4-iodoquinoline Preparation Products And Raw materials
6-Bromo-4-iodoquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei Ruiluo New Material Technology Co., Ltd. | 19567218739 | 1759672789@qq.com | China | 569 | 58 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4905 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai XinKai Chemical Technology Co., Ltd. | 021-58930698 15921516558 | zhangyichao84@126.com | China | 979 | 55 |
View Latest Price from 6-Bromo-4-iodoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 6-BROMO-4-IODOQUINOLINE
927801-23-8
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- 6-BROMO-4-IODOQUINOLINE
927801-23-8
- $1.00
- 95-99%
- Career Henan Chemical Co
