EHNA HYDROCHLORIDE
- CAS No.
- 51350-19-7
- Chemical Name:
- EHNA HYDROCHLORIDE
- Synonyms
- EHNA;EHNA HCL;NSC-263165;MEP1 HYDROCHLORIDE;EHNA HYDROCHLORIDE;9-erythro-(2-Hydroxyl-3-nonyl)adenine;(+)-erythro-9-(2-Hydroxy-3-nonyl)adenine;ERYTHRO-9-(2-HYDROXY-3-NONYL)ADENINE, HCL;ERYTHRO-9-(2-HYDROXY-3-NONYL)ADENINE HYDROCHLORIDE;9-erythro-(2-Hydroxy-3-nonyl)-adenine hydrochloride
- CBNumber:
- CB1233267
- Molecular Formula:
- C14H23N5O
- Molecular Weight:
- 277.37
- MDL Number:
- MFCD00151066
- MOL File:
- 51350-19-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem | 324630 | 10mg | $109 |
| 9-erythro-(2-Hydroxyl-3-nonyl)adenine | 440410 | 25mg | $403 |
| 9-erythro-(2-Hydroxyl-3-nonyl)adenine | 440410 | 50mg | $595 |
| EHNA | AA006WFZ | 10mg | $125 |
| EHNA | AA006WFZ | 50mg | $350 |
| Melting point | 183～184℃ |
|---|---|
| storage temp. | 0-6°C |
| solubility | DMSO: 12 mg/mL |
| form | solid |
| color | white |
| Water Solubility | water: 25mg/mL |
| Stability | Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| InChI | 1S/C14H23N5O/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17)/t10-,11-/m0/s1 |
| InChIKey | IOSAAWHGJUZBOG-QWRGUYRKSA-N |
| SMILES | [n]1(c2ncnc(c2nc1)N)[C@H]([C@@H](O)C)CCCCCC |
| CAS DataBase Reference | 51350-19-7 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
EHNA HYDROCHLORIDE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 324630 | EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem | 51350-19-7 | 10mg | $109 | 2026-04-30 | Buy |
| Usbiological | 440410 | 9-erythro-(2-Hydroxyl-3-nonyl)adenine | 51350-19-7 | 25mg | $403 | 2026-06-03 | Buy |
| Usbiological | 440410 | 9-erythro-(2-Hydroxyl-3-nonyl)adenine | 51350-19-7 | 50mg | $595 | 2026-06-03 | Buy |
| aablocks | AA006WFZ | EHNA | 51350-19-7 | 10mg | $125 | 2026-05-28 | Buy |
| aablocks | AA006WFZ | EHNA | 51350-19-7 | 50mg | $350 | 2026-05-28 | Buy |
EHNA HYDROCHLORIDE Chemical Properties,Uses,Production
Description
EHNA (51350-19-7) inhibits phosphodiesterase 2 (PDE2) (IC50 = 0.8 – 5.5 μM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 values > 100 μM).1,2 It also inhibits adenosine deaminase (ADA), IC50 = 1.2 and 1.5 μM in human RBCs and astrocytoma cells, respectively3, which may be responsible for its ability to induce apoptosis in malignant pleural mesothelioma cell lines4. Because it blocks breakdown of adenosine to inosine and hypoxanthine, EHNA prevents formation of free radical substrates, protecting against cardiac reperfusion-mediated injury.5 It inhibits differentiation and maintains expression of pluripotency markers in hESCs, but not through inhibition of PDEs or ADA.6
Chemical Properties
White Solid
Uses
A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM)
Uses
9-erythro-(2-Hydroxyl-3-nonyl)adenine is an intermediate in the synthesis of potent inhibitor of phosphodiesterase II.
Definition
ChEBI: (2R,3S)-EHNA is eHNA of absolute configuration 2R,3S. Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. It has a role as an EC 3.5.4.4 (adenosine deaminase) inhibitor and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor. It is a conjugate base of a (2R,3S)-EHNA(1+). It is an enantiomer of a (2S,3R)-EHNA.
Biological Activity
Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC 50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase.
References
[1] THOMAS PODZUWEIT Antje M Peter Nennstiel. Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine[J]. Cellular signalling, 1995, 7 7: Pages 733-738. DOI:10.1016/0898-6568(95)00042-n
[2] P F MÉRY. Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes.[J]. Molecular Pharmacology, 1995, 48 1: 121-130.
[3] J BARANKIEWICZ. Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors.[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 283 3: 1230-1238.
[4] YASUHIRO NAKAJIMA. Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma.[J]. Cellular Physiology and Biochemistry, 2015: 51-60. DOI:10.1159/000369674
[5] ANWAR S. ABD-ELFATTAH PH.D. Andrew S W M D. Separation Between Ischemic and Reperfusion Injury by Site Specific Entrapment of Endogenous Adenosine and Inosine Using NBMPR and EHNA[J]. Journal of Cardiac Surgery, 1994, 9 3S: 387-396. DOI:10.1111/jocs.1994.9.3s.387
[6] PETER BURTON. Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.[J]. Biochemical Journal, 2010, 432 3: 575-584. DOI:10.1042/bj20100726
EHNA HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
EHNA HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NewCan Biotech Limited | +86-571-86912261 19975279805 | sales@newcanbio.com | China | 9985 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29974 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9863 | 58 |
