OXOMEMAZINE
- CAS No.
- 3689-50-7
- Chemical Name:
- OXOMEMAZINE
- Synonyms
- Imakol;6847 RP;6487 RP;Dysedon;RP-6847;Doxergan;Dosegran;6847 R.P.;Oxomemazin;OXOEMAZINE
- CBNumber:
- CB1236273
- Molecular Formula:
- C18H22N2O2S
- Molecular Weight:
- 330.44
- MDL Number:
- MFCD00868197
- MOL File:
- 3689-50-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (±)-Oxomemazine ≥98% | 39511 | 100mg | $215 |
| (±)-Oxomemazine ≥98% | 39511 | 250mg | $510 |
| (±)-Oxomemazine ≥98% | 39511 | 500mg | $966 |
| (±)-Oxomemazine ≥98% | 39511 | 1g | $1287 |
| Oxomemazine 99.18% | CS-0131898 | 5mg | $41 |
| Melting point | 115° |
|---|---|
| Boiling point | 492.4±34.0 °C(Predicted) |
| Density | 1.1453 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Store at -20°C |
| solubility | ≥ 33mg/mL in DMSO |
| form | Solid |
| pka | 9.31±0.28(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C18H22N2O2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)23(21,22)18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3 |
| InChIKey | QTQPVLDZQVPLGV-UHFFFAOYSA-N |
| SMILES | N1(CC(C)CN(C)C)C2C=CC=CC=2S(=O)(=O)C2C=CC=CC1=2 |
| FDA UNII | 305MB38V1C |
| ATC code | R06AD08 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H330-H311-H301 |
| Precautionary statements | P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501 |
| Toxicity | LD50 oral in mouse: 140mg/kg |
OXOMEMAZINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 39511 | (±)-Oxomemazine ≥98% | 3689-50-7 | 100mg | $215 | 2026-04-30 | Buy |
| Cayman Chemical | 39511 | (±)-Oxomemazine ≥98% | 3689-50-7 | 250mg | $510 | 2026-04-30 | Buy |
| Cayman Chemical | 39511 | (±)-Oxomemazine ≥98% | 3689-50-7 | 500mg | $966 | 2026-04-30 | Buy |
| Cayman Chemical | 39511 | (±)-Oxomemazine ≥98% | 3689-50-7 | 1g | $1287 | 2026-04-30 | Buy |
| ChemScene | CS-0131898 | Oxomemazine 99.18% | 3689-50-7 | 5mg | $41 | 2026-06-04 | Buy |
OXOMEMAZINE Chemical Properties,Uses,Production
Originator
Doxergan,Specia,France,1964
History
The development of oxomemazine is the result of a systematic exploration of phenothiazine compounds in the mid-20th century. Following the significant sedative effects of the first-generation antihistamine promethazine, scientists focused on optimizing its pharmacological properties through structural modification. In the late 1950s and early 1960s, researchers synthesized oxomemazine by chemically modifying the side chains of promethazine. This new compound retained potent antihistamine activity while enhancing its antitussive and sedative effects. Based on these properties, oxomemazine was marketed as an antitussive in the 1960s, often under the brand name Toplexil®, and was particularly suitable for treating allergic dry cough accompanied by sleep disturbances.
Uses
(±)-Oxomemazine, is a phenothiazine-type antihistamines, that has also shown antibacterial activity against Mycobacterium tuberculosis.
Definition
ChEBI: Oxomemazine is a member of phenothiazines.
Manufacturing Process
Phenothiazine is reacted with 3-dimethylamino-2-methylpropyl chloride in the presence of sodium amide to give 3-(10-phenthiazinyl)-2-methyl-1dimethylaminopropane. 11.9 g of of this intermediate is dissolved with agitation in glacial acetic acid (120 cc). Pure sulfuric acid (d = 1.83; 0.5 cc) is added and a mixture of glacial acetic acid (10 cc) and hydrogen peroxide (8.5 cc of a solution containing 38 g of hydrogen peroxide in 100 cc) is then run in over 20 minutes. The temperature rises from 25°C to 35°C and is then kept at 60°C for 18 hours. The mixture is cooled and water (150 cc) is added and, with cooling, aqueous sodium hydroxide (d = 1.33; 220 cc). The resulting
mixture is extracted with ethyl acetate (3 x 100 cc), the solvent is evaporated on a water bath and the residue is recrystallized from heptane (150 cc). 3(9,9-dioxy-10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (78 g) is obtained, MP 115°C.
The corresponding hydrochloride prepared in ethyl acetate and recrystallized from a mixture of ethanol and isopropanol melts at 250°C.
Therapeutic Function
Antihistaminic
OXOMEMAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
OXOMEMAZINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shijiazhuang Gantuo Biotechnology Co., Ltd | gantuo02@cngantuo.com | China | 196 | 58 | |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15058 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-86-17392712779 +86-13289823923 | 1090@dideu.com | China | 8651 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 |
View Lastest Price from OXOMEMAZINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | OXOMEMAZINE
3689-50-7
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-04-22 | OXOMEMAZINE
3689-50-7
|
$30.00 | 99.58% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-06-26 | Oxomemazine
3689-50-7
|
$200.00 | 1kg | 99% | 1000kg/Month | Hebei Mingeng Biotechnology Co., Ltd |
-
- OXOMEMAZINE
3689-50-7
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- OXOMEMAZINE
3689-50-7
- $30.00
- 99.58%
- TargetMol Chemicals Inc.
-
- Oxomemazine
3689-50-7
- $200.00
- 99%
- Hebei Mingeng Biotechnology Co., Ltd
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