Ethyl 4-chloro-3-quinolinecarboxylate
- CAS No.
- 13720-94-0
- Chemical Name:
- Ethyl 4-chloro-3-quinolinecarboxylate
- Synonyms
- ETHYL 4-CHLOROQUINOLINE-3-CARBOXYLATE;NSC 136916;NSC 109461;AURORA 18125;4-CHLORO-3-QUINOLINECARBOXYLATE;Ethyl 4-chloro-3-quinolinecarboxylate;4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester;4-chloro-3-Quinolinecarboxylic acid ethyl ester (6CI 8CI 9CI ACI);3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester (6CI, 8CI, 9CI, ACI)
- CBNumber:
- CB1245057
- Molecular Formula:
- C12H10ClNO2
- Molecular Weight:
- 235.67
- MDL Number:
- MFCD00173407
- MOL File:
- 13720-94-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 46-48°C |
|---|---|
| Boiling point | 128-129 °C(Press: 0.2 Torr) |
| Density | 1.286 |
| storage temp. | Storage temp. -20°C |
| pka | 1.78±0.24(Predicted) |
| form | powder to crystal |
| color | White to Orange to Green |
| InChI | 1S/C12H10ClNO2/c1-2-16-12(15)9-7-14-10-6-4-3-5-8(10)11(9)13/h3-7H,2H2,1H3 |
| InChIKey | DWXQUAHMZWZXHP-UHFFFAOYSA-N |
| SMILES | CCOC(=O)c1cnc2ccccc2c1Cl |
| CAS DataBase Reference | 13720-94-0(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-36 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933499090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
Ethyl 4-chloro-3-quinolinecarboxylate price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | JRD0194 | Ethyl 4-chloroquinoline-3-carboxylate Aldrich | 13720-94-0 | 1g | $304 | 2026-04-30 | Buy |
| TCI Chemical | E1201 | Ethyl 4-Chloroquinoline-3-carboxylate | 13720-94-0 | 200MG | $41 | 2026-04-30 | Buy |
| TCI Chemical | E1201 | Ethyl 4-Chloroquinoline-3-carboxylate | 13720-94-0 | 1G | $188 | 2024-03-01 | Buy |
| Apolloscientific | OR309348 | 4-Chloroquinoline-3-carboxylic acid ethyl ester 98% | 13720-94-0 | 1g | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR309348 | 4-Chloroquinoline-3-carboxylic acid ethyl ester 98% | 13720-94-0 | 5g | $62 | 2026-06-04 | Buy |
Ethyl 4-chloro-3-quinolinecarboxylate Chemical Properties,Uses,Production
Uses
Ethyl 4-chloroquinoline-3-carboxylate is used as organic chemical synthesis intermediate.
Synthesis
26892-90-0
13720-94-0
Synthesis of ethyl 4-chloroquinoline-3-carboxylate (A2): ethyl 4-hydroxyquinoline-3-carboxylate (A1) (1.5 g, 7 mmol) solid was placed in a reaction vial and phosphorus oxychloride (POCl3) (2.2 g, 1.3 mL, 14 mmol) was added. The reaction mixture was heated at 110 °C for 20 min. Upon completion of the reaction, the mixture was slowly poured into a pre-cooled mixture of aqueous ammonia solution (28-30%) and ice and stirred until a granular solid was formed. The reaction mixture was extracted with ether (3 x 40 mL), the organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give an oily product. After standing, the product crystallized (1.44 g, 6 mmol, 87% yield) and could be used for subsequent reactions without further purification.
References
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 21, p. 6351 - 6363
[2] Patent: WO2005/123686, 2005, A1. Location in patent: Page/Page column 75-76
[3] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 1 - 16
[4] Patent: CN108623589, 2018, A. Location in patent: Paragraph 0142; 0149
[5] Patent: CN108623581, 2018, A. Location in patent: Page/Page column 7
Ethyl 4-chloro-3-quinolinecarboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
View Lastest Price from Ethyl 4-chloro-3-quinolinecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE
13720-94-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-09 | ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE
13720-94-0
|
500g | 98%; 99% | 500g；1kg； 10kg; 25kg | Career Henan Chemical Co |
-
- ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE
13720-94-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE
13720-94-0
- $0.01
- 98%; 99%
- Career Henan Chemical Co
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