PYRIDINE, 2,6-DIFLUORO-4-IODO-
- CAS No.
- 685517-71-9
- Chemical Name:
- PYRIDINE, 2,6-DIFLUORO-4-IODO-
- Synonyms
- 2 6-DICHLORO-4-IODOPYRI;2,6-fluoro-4-iodopyridine;4-Iodo-2,6-difluoropyridine;2,6-DIFLUORO-4-IODODPYRIDINE;2,6-difluoro-4- iodo-Pyridine;PYRIDINE, 2,6-DIFLUORO-4-IODO-
- CBNumber:
- CB12468476
- Molecular Formula:
- C5H2F2IN
- Molecular Weight:
- 240.98
- MDL Number:
- MFCD11977432
- MOL File:
- 685517-71-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,6-Difluoro-4-iodopyridine | D448733 | 50mg | $45 |
| 2,6-Difluoro-4-iodopyridine | 9718AL | 250mg | $46 |
| 2,6-Difluoro-4-iodopyridine | 446274 | 250mg | $22 |
| 2,6-Difluoro-4-iodopyridine 97% | PC502363 | 1g | $65 |
| 2,6-Difluoro-4-iodopyridine 97% | 3H32-K-38 | 1g | $104 |
| More product size | |||
| Melting point | 80-82 °C(Solv: ligroine (8032-32-4)) |
|---|---|
| Boiling point | 222.0±35.0 °C(Predicted) |
| Density | 2.129±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -7.48±0.10(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C5H2F2IN/c6-4-1-3(8)2-5(7)9-4/h1-2H |
| InChIKey | AXPNCSVJCFXRBC-UHFFFAOYSA-N |
| SMILES | C1(F)=NC(F)=CC(I)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H318-H315-H335 |
| Precautionary statements | P280-P305+P351+P338-P310-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2933399990 |
PYRIDINE, 2,6-DIFLUORO-4-IODO- price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D448733 | 2,6-Difluoro-4-iodopyridine | 685517-71-9 | 50mg | $45 | 2021-12-16 | Buy |
| AK Scientific | 9718AL | 2,6-Difluoro-4-iodopyridine | 685517-71-9 | 250mg | $46 | 2021-12-16 | Buy |
| Oakwood | 446274 | 2,6-Difluoro-4-iodopyridine | 685517-71-9 | 250mg | $22 | 2021-12-16 | Buy |
| Apolloscientific | PC502363 | 2,6-Difluoro-4-iodopyridine 97% | 685517-71-9 | 1g | $65 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H32-K-38 | 2,6-Difluoro-4-iodopyridine 97% | 685517-71-9 | 1g | $104 | 2021-12-16 | Buy |
PYRIDINE, 2,6-DIFLUORO-4-IODO- Chemical Properties,Uses,Production
Synthesis
685517-67-3
685517-71-9
The general procedure for the synthesis of 2,6-difluoro-4-iodopyridine from 2,6-difluoro-3-iodopyridine was as follows: n-butyllithium (1.66 mL, 4.15 mmol, 2.5 mol/L hexane solution) was slowly added dropwise to a solution of tetrahydrofuran (THF, 2 mL) with diisopropylamine (1.30 mL, 4.15 mmol) at -78 °C. 25 minutes later, a solution of 2,6-difluoro-3-iodopyridine (1.00 g, 4.15 mmol) in THF (5 mL) was added dropwise to the above mixture via cannula. The reaction mixture was kept at -78 °C for 12 h. THF (2 mL) solution in water (0.2 mL, 11 mmol) was subsequently added and slowly warmed up to room temperature over a period of 1 h. The reaction was carried out at -78 °C for 1 h. The reaction was carried out in a controlled manner. Upon completion of the reaction, the reaction mixture was washed with 10% aqueous Na2SO3 solution (5 mL) and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure. The target product 2,6-difluoro-4-iodopyridine was obtained by hexane crystallization as colorless crystals (740 mg, 74% yield). The product was characterized as follows: 1H NMR (400 MHz, CDCl3): δ 7.22 (t, 2H, J = 1.2 Hz); 13C NMR (100 MHz, CDCl3): δ 161.1 (dd, J = 250, 16 Hz, 2C), 115.6 (dd, J = 24, 10 Hz, 2C), 110.3; 19F NMR (376 MHz, CDCl3): δ -68.1; GC-MS m/z: Calculated value 241 [M+], measured value 241; Melting point: 78-80 °C.
References
[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 18, p. 5026 - 5030
[2] Angew. Chem., 2017, vol. 129, p. 5108 - 5112,5
[3] Chinese Chemical Letters, 2017, vol. 28, # 3, p. 525 - 530
[4] Organic Letters, 2007, vol. 9, # 25, p. 5175 - 5178
PYRIDINE, 2,6-DIFLUORO-4-IODO- Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2161 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
View Lastest Price from PYRIDINE, 2,6-DIFLUORO-4-IODO- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | PYRIDINE, 2,6-DIFLUORO-4-IODO-
685517-71-9
|
US $1.00 / KG | 1KG | 95% | 500KG | Career Henan Chemical Co |
-
- PYRIDINE, 2,6-DIFLUORO-4-IODO-
685517-71-9
- US $1.00 / KG
- 95%
- Career Henan Chemical Co
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