（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine
- CAS No.
- 13500-53-3
- Chemical Name:
- （2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine
- Synonyms
- (2S,4R)-Dibenzyl 4-hydroxypyrrolidine-1,2-dicarboxylate;（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine;dibenzyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;DIBENZYL (2S,4R)-4-HYDROXY-1,2-PYRROLIDINEDICARBOXYLATE;N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester;1,2-dibenzyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;(2S,4R)-4-hydroxypyrolidine-1,2-dicarboxylic acidibenzyl ester;(2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylic acid dibenzyl ester;(2S,4R)-4-hydroxy-1,2-Pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester;1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1,2-bis(phenylmethyl) ester, (2S,4R)-
- CBNumber:
- CB12469882
- Molecular Formula:
- C20H21NO5
- Molecular Weight:
- 355.38
- MDL Number:
- MFCD12407103
- MOL File:
- 13500-53-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (2S,4R)-1,2-DICARBOBENZYLOXY-4-HYDROXYPYRROLIDINE 95.00% | CCH0001436 | 250MG | $204.75 |
| (2S,4R)-1,2-Dicarbobenzyloxy-4-hydroxypyrrolidine 98% | 057252 | 1g | $292 |
| (2S,4R)-1,2-Dicarbobenzyloxy-4-hydroxypyrrolidine | X6459 | 1g | $304 |
| (2S,4R)-1,2-Dicarbobenzyloxy-4-hydroxypyrrolidine | X6459 | 5g | $791 |
| (2S,4R)-1,2-DICARBOBENZYLOXY-4-HYDROXYPYRROLIDINE 95.00% | CCH0001436 | 1G | $898.59 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| HazardClass | IRRITANT |
（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CCH0001436 | (2S,4R)-1,2-DICARBOBENZYLOXY-4-HYDROXYPYRROLIDINE 95.00% | 13500-53-3 | 250MG | $204.75 | 2021-12-16 | Buy |
| Matrix Scientific | 057252 | (2S,4R)-1,2-Dicarbobenzyloxy-4-hydroxypyrrolidine 98% | 13500-53-3 | 1g | $292 | 2021-12-16 | Buy |
| AK Scientific | X6459 | (2S,4R)-1,2-Dicarbobenzyloxy-4-hydroxypyrrolidine | 13500-53-3 | 1g | $304 | 2021-12-16 | Buy |
| AK Scientific | X6459 | (2S,4R)-1,2-Dicarbobenzyloxy-4-hydroxypyrrolidine | 13500-53-3 | 5g | $791 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0001436 | (2S,4R)-1,2-DICARBOBENZYLOXY-4-HYDROXYPYRROLIDINE 95.00% | 13500-53-3 | 1G | $898.59 | 2021-12-16 | Buy |
（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine Chemical Properties,Uses,Production
Synthesis
100-39-0
13504-85-3
13500-53-3
A solution of triethylamine (15 mmol, 3.98 g) and benzyl bromide (16.5 mmol, 2.82 g) in THF (25 mL) at 0 °C was added to Cbz-L-hydroxyproline. The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was dissolved in 50 mL of dichloromethane and washed sequentially with 1N HCl, water, 5% Na2CO3 solution and water. The organic layer was dried with anhydrous Na2SO4, filtered and the solvent evaporated. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 2:1) to afford (2S,4R)-1,2-dibenzyloxycarbonyl-4-hydroxypyrrolidine (Compound 3) as a light yellow oil (2.66 g, 50% yield).
References
[1] Advanced Synthesis and Catalysis, 2008, vol. 350, # 17, p. 2747 - 2760
[2] Journal of Organic Chemistry, 2001, vol. 66, # 3, p. 1038 - 1042
[3] Angewandte Chemie - International Edition, 2007, vol. 46, # 47, p. 9073 - 9077
[4] Synlett, 1999, # 9, p. 1465 - 1467
[5] Tetrahedron, 2008, vol. 64, # 10, p. 2480 - 2488
（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
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| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Mainchem Co., Ltd. | -- | sarah@mainchem.com | China | 6547 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 028-85114309 18982182443 | yangli@happysyn.com | China | 2179 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9891 | 58 | |
| SynAsst Chemical. | 021-60343070 | China | 12740 | 55 |
