(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid
- CAS No.
- 122225-33-6
- Chemical Name:
- (R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid
- Synonyms
- 5-CHLOROMETHYL-3-OXAZOLIDINONE;(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid;(R)-2-Benzylbutanedioic acid 4-tert-butyl ester;1H-Imidazole-4-carboxylicacid,1-(5-bromophenyl)-;Butanedioic acid, 2-(phenylmethyl)-, 4-(1,1-dimethylethyl) ester, (2R)-
- CBNumber:
- CB12470529
- Molecular Formula:
- C15H20O4
- Molecular Weight:
- 264.32
- MDL Number:
- MFCD12755810
- MOL File:
- 122225-33-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (R)-2-Benzyl-4-tert-butoxy-4-oxobutanoic acid 97%EE | AS3408-2R | 250mg | $213 |
| (R)-2-Benzyl-4-tert-butoxy-4-oxobutanoic acid 97%EE | AS3408-2R | 1g | $538 |
| (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid | 309613 | 100.00mg | $128 |
| (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid | 309613 | 250.00mg | $171 |
| (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid | 309613 | 1.00g | $422 |
| Melting point | 57.0-59.8 °C |
|---|---|
| Boiling point | 400.4±38.0 °C(Predicted) |
| Density | 1.118 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 4.17±0.10(Predicted) |
| Appearance | white solid |
| CAS DataBase Reference | 122225-33-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS3408-2R | (R)-2-Benzyl-4-tert-butoxy-4-oxobutanoic acid 97%EE | 122225-33-6 | 250mg | $213 | 2026-06-04 | Buy |
| Activate Scientific | AS3408-2R | (R)-2-Benzyl-4-tert-butoxy-4-oxobutanoic acid 97%EE | 122225-33-6 | 1g | $538 | 2026-06-04 | Buy |
| Matrix Scientific | 309613 | (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid | 122225-33-6 | 100.00mg | $128 | 2026-05-19 | Buy |
| Matrix Scientific | 309613 | (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid | 122225-33-6 | 250.00mg | $171 | 2026-05-19 | Buy |
| Matrix Scientific | 309613 | (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid | 122225-33-6 | 1.00g | $422 | 2026-05-19 | Buy |
(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid Chemical Properties,Uses,Production
Uses
(R)-2-benzyl-4-tert-butoxy-4-oxobutyric acid is an organic intermediate that can be prepared from maleic anhydride and benzaldehyde through a six-step reaction.
Synthesis
1229380-18-0
122225-33-6
To a solution of tert-butyl (R)-4-methyl-2-benzyl succinate (308 mg, 1.11 mmol) in tetrahydrofuran (THF, 3 mL) was added an aqueous solution (3 mL) of lithium hydroxide (107 mg, 4.44 mmol). The reaction mixture was stirred at room temperature overnight. Completion of the reaction was confirmed by monitoring the progress of the reaction by thin layer chromatography (TLC, unfolding agent: cyclohexane/ethyl acetate = 7/3). The reaction mixture was acidified to pH = 1 with 2 M hydrochloric acid (HCl) and then extracted with dichloromethane (DCM, 2 x 20 mL). The organic layers were combined and the solvent was evaporated after separation by a phase separator. The crude product was purified by fast column chromatography (eluent: cyclohexane/ethyl acetate = 9/1 → 7/3), using the starting eluent as solution loading, to afford (R)-2-benzyl-4-(tert-butoxy)-4-oxobutanoic acid as a colorless oil. Yield: 274 mg (94%), purity > 95%, retention time (rt) = 4.17 min (gradient A), mass spectrum (M + H)+ = 209 (loss of tert-butyl).
References
[1] Patent: WO2010/66682, 2010, A1. Location in patent: Page/Page column 207-208
(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16512 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 | info@afinechem.com | China | 15080 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49923 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29974 | 65 |
View Lastest Price from (R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-02 | (R)-2-Benzylbutanedioic acid 4-tert-butyl ester
122225-33-6
|
$2.00-6.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- (R)-2-Benzylbutanedioic acid 4-tert-butyl ester
122225-33-6
- $2.00-6.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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