Piperine
- CAS No.
- 94-62-2
- Chemical Name:
- Piperine
- Synonyms
- Bioperine;(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one;Piperin;FEMA 2909;Piperine Powder;1-PIPERYLPIPERIDINE;1-PIPEROYLPIPERIDINE;(E,E)-1-[5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-piperidine;PIPERINE;Piperine
- CBNumber:
- CB1249813
- Molecular Formula:
- C17H19NO3
Lewis structure
- Molecular Weight:
- 285.34
- MDL Number:
- MFCD00005839
- MOL File:
- 94-62-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Piperine ≥95%, FG | W290904 | 1 each | $76.6 |
| Piperine European Pharmacopoeia (EP) Reference Standard | Y0001217 | 30 mg | $167 |
| Piperine ≥95%, FG | W290904 | 100g | $279 |
| Piperine ≥95%, FG | W290904 | 1kg | $1590 |
| Piperine Pharmaceutical Secondary Standard; Certified Reference Material | PHR2211 | 50mg | $182 |
| More product size | |||
| Melting point | 131-135 °C(lit.) |
|---|---|
| Boiling point | 427.77°C (rough estimate) |
| Density | 1.0864 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| FEMA | 2909 | PIPERINE |
| FLAVIS Number | 14.003 | Piperine |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Slightly soluble in water, 10% soluble in alcohol, soluble only in certain oils |
| form | Crystalline Powder |
| pka | 12.22(at 18℃) |
| color | Off-white to tan or yellow-tan |
| Odor | at 1.00 % in propylene glycol. pepper animal |
| Odor Type | spicy |
| Water Solubility | 40 mg/L (18 ºC) |
| JECFA Number | 1600 |
| Merck | 14,7472 |
| BRN | 90741 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions | SKIN CONDITIONING - MISCELLANEOUS |
| InChI | 1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+ |
| InChIKey | MXXWOMGUGJBKIW-YPCIICBESA-N |
| SMILES | O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3 |
| LogP | 2.66 |
| CAS DataBase Reference | 94-62-2(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | PIPERINE |
| EWG's Food Scores | 1 |
| FDA UNII | U71XL721QK |
| NCI Drug Dictionary | Bioperine |
| NIST Chemistry Reference | Piperine(94-62-2) |
| EPA Substance Registry System | 2,4-Pentadien-1-one, 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-, (2E,4E)- (94-62-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H411 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi,N | |||||||||
| Risk Statements | 22-21/22-20/21/22-51/53 | |||||||||
| Safety Statements | 22-24/25-36/37-36-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TN2321500 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 2 |
|||||||||
| Toxicity | LD50 orally in Rabbit: 514 mg/kg | |||||||||
| NFPA 704 |
|
Piperine price More Price(131)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W290904 | Piperine ≥95%, FG | 94-62-2 | 1 each | $76.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001217 | Piperine European Pharmacopoeia (EP) Reference Standard | 94-62-2 | 30 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | W290904 | Piperine ≥95%, FG | 94-62-2 | 100g | $279 | 2026-04-30 | Buy |
| Sigma-Aldrich | W290904 | Piperine ≥95%, FG | 94-62-2 | 1kg | $1590 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2211 | Piperine Pharmaceutical Secondary Standard; Certified Reference Material | 94-62-2 | 50mg | $182 | 2026-04-30 | Buy |
Piperine Chemical Properties,Uses,Production
Description
Piperine is an alkaloid responsible for the taste and fl avor of pepper. In pure form it exists as a yellow to pale-yellow crystal, with a burning taste and pungent order. It is found naturally in plants in the Piperaceae family, particularly Piper nigrum (black pepper) and Piper longum (Indian long pepper). Piper nigrum is a perennial woody vine that grows to approximately 30 feet. It produces spikelike flowers that hold berries called peppercorns.
Chemical Properties
Piperine is odorless. It is tasteless at first, but develops a burning aftertaste of pepper.
Chemical Properties
light yellow powder
Occurrence
Reported found in black pepper; also in Piper longum, Piper officinarum, Piper lowong BI., Piper famechoni, Piper chaba and the leaves of Rhododendron fauriae var. rupescens.
History
Hans Christian Oersted (1777 1851) isolated piperine from black pepper in 1819 and published his findings in 1820. Oersted extracted a resin from pepper plants with alcohol, formed a soluble saltby adding hydrochloric acid with alcohol, and then separated piperine from solution by precipitation and distillation. In 1882, Leopold Rügheimer (1850 1917) synthesized piperine from piperinic acid chloride and piperidine. The complete synthesis of piperine was reported in 1894 by Albert Ladenburg (1842 1911) and M. Scholtz. Ladenburg and Scholtz used piperonal (C8H6O3) and acetaldehyde (CH3CHO) to produce piperinic acid (C12H10O4), which was then reacted with thionyl chloride (COCl2) and piperidine (C5H11N) to produce piperine.
Uses
Piperine is used in granular formulations as a pesticide against small animals such as dogs, cats, skunks, raccoons, and squirrels. Piperine pesticides are nontoxic and operate as a repellant when animals smell or test them. Piperine is also incorporated with other compounds to make insecticides; it is effective against houseflies, lice, and various other pests.
Piperine has been used medicinally for thousands of years and this continues today. It is used to treat asthma and chronic bronchitis. It also has putative analgesic and antiinfl ammatory properties that stem from its antioxidant properties. Research is examining the use of piperine in treating malaria. Antiepilepsirine is a derivative of piperine that is used to treat different types of epilepsy, especially in China. A current area of interest is the efficacy of piperine in increasing the bioavailability of certain nutrients and drugs. It is thought to possibly aid digestion and increase the absorption in the digestive tract of numerous drugs used as cancer treatments, antihistamines, steroidal inflammation reducers, and antibiotics.
Uses
The alkaloid which gives pepper its spiciness, and has been used as an organic insecticide.
Uses
analeptic, antibacterial
Uses
A black pepper extract TRPV1 activator.
It finds use in flavor compositions, not only
as ingredient in artificial Black Pepper, but
also in various spice blends, and as an additive
to the flavor composition used in "Celery
Soda" (a carbonated beverage of sweet, but
pungent Celery flavor, sometimes used as an
appetizer).
Preparation
From piperoyl chloride and piperidine.
Definition
ChEBI: Piperine is a N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. It has a role as a NF-kappaB inhibitor, a plant metabolite, a food component and a human blood serum metabolite. It is a member of benzodioxoles, a N-acylpiperidine, a piperidine alkaloid and a tertiary carboxamide. It is functionally related to an (E,E)-piperic acid.
Safety Profile
Poison by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Piperine crystallises as light yellow crystals from EtOH or EtOAc (m 132o), aqueous EtOH (m 128-129o), Et2O (m129o), or*benzene/ligroin. [Beilstein 20 H 79, 20 I 23, 20 II 53, 20 III/IV 1341, 20/3 V 469.]
References
Oersred., Schweigger's Journal, 29, 80 (1819)
Fliickiger, Hanbury., Pharmacographica, 584 London (1879)
Stenhouse., Pharm. J., 14,363 (1855)
Cazeneuve, Caillot., Bull. Soc. Chim. Fr., 27,291 (1877)
Riigheimer., Ber., 15, 1391 (1882)
Peinemann., Arch. Pharm., 234, 245 (1896)
Newman., Chem. Products, 16,379 (1953)
Piperine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 906 | 58 |
| Lianyungang Kaiyu Environmental Tech Co., Ltd. | +86-0086-19851820538 +8619851820538 | carlos@khonorchem.com | China | 314 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 670 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
View Lastest Price from Piperine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-06 | Piperine
94-62-2
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-06-06 | Piperine; Sichuan?Pepper oil | 1KG | >99% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
 |
2026-06-02 | Piperine
94-62-2
|
1kg | 0.99 | 1000kg | Shaanxi Xianhe Biotech Co., Ltd |
-
- Piperine
94-62-2
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Piperine; Sichuan?Pepper oil
- $0.00
- >99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Piperine
94-62-2
- $0.00
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
