CRA-02478
- CAS No.
- 783355-60-2
- Chemical Name:
- CRA-02478
- Synonyms
- Abexinostat;CS-423;PCI-24781;CRA-02478;CRA 24781;CRA 024781;PCI-24781, >=98%;PCI-24781;CRA-02478;CRA-02478 PCI-24781;PCI-24781(CRA-024781)
- CBNumber:
- CB12501009
- Molecular Formula:
- C21H23N3O5
- Molecular Weight:
- 397.42
- MDL Number:
- MFCD10565969
- MOL File:
- 783355-60-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| PCI-24781 ≥98% (HPLC) | SML4043 | 5 mg | $84.7 |
| PCI-24781 ≥98% (HPLC) | SML4043 | 25 mg | $342 |
| PCI-24781 ≥98% (HPLC) | SML4043 | 1 unit | $319 |
| PCI 24781 ≥95% | 20059 | 1mg | $36 |
| PCI 24781 ≥95% | 20059 | 5mg | $110 |
| More product size | |||
| Melting point | 198-202oC (dec.) |
|---|---|
| Density | 1.284 |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 9.04±0.10(Predicted) |
| color | White |
| InChI | 1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25) |
| InChIKey | MAUCONCHVWBMHK-UHFFFAOYSA-N |
| SMILES | N(O)C(=O)c1ccc(cc1)OCCNC(=O)c2[o]c3c(c2CN(C)C)cccc3 || CN(C)CC1=C(C(NCCOC2=CC=C(C(NO)=O)C=C2)=O)OC3=CC=CC=C31 |
| NCI Dictionary of Cancer Terms | CRA-024781 |
| FDA UNII | IYO470654U |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
CRA-02478 price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML4043 | PCI-24781 ≥98% (HPLC) | 783355-60-2 | 5 mg | $84.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML4043 | PCI-24781 ≥98% (HPLC) | 783355-60-2 | 25 mg | $342 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML4043 | PCI-24781 ≥98% (HPLC) | 783355-60-2 | 1 unit | $319 | 2025-07-31 | Buy |
| Cayman Chemical | 20059 | PCI 24781 ≥95% | 783355-60-2 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 20059 | PCI 24781 ≥95% | 783355-60-2 | 5mg | $110 | 2026-04-30 | Buy |
CRA-02478 Chemical Properties,Uses,Production
Uses
PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor). PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.
Definition
ChEBI: 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide is a member of benzofurans.
Biological Activity
cra-024781 is a novel hdac inhibitor targeting hdac1, hdac2, hadc3, hadc6, hadc8, hadc10 with ic50 value of 7 nm(ki), 19 nm(ki), 8.2 nm(ki), 17 nm(ki), 280 nm(ki), 24 nm(ki), respectively [1].histone deacetylases (hdac) are a class of enzymes that remove acetyl groups (o=c-ch3) from an ε-n-acetyl lysine amino acid on a histone, allowing the histones to wrap the dna more tightly.cra-024781 exhibits potent antitumor activity against ten human tumor cell lines with gi50 ranging from 0.15 μm to 3.09 μm. cra-024781 also has an antiproliferative effect on huvec endothelial cells with gi50 of 0.43 μm. cra-024781 treatment causes dose-dependent accumulation of both acetylated histones and acetylated tubulin in hct116 or dld-1 cells suggesting that hdac enzymes are inhibited in these cells. cra-024781 also induces the expression of p21 (a protein playing a role in the antitumor effect) and leads to parp cleavage and accumulation of the γh2ax, which indicate apoptosis [1].treatment with cra-024781 at 200 mg/kg once daily every other day significantly inhibits the growth of hct116 and dld-1 xenografts in mice by 69% and 59%, respectively. in the hct116 model, treatment with cra-024781 at 20 mg/kg, 40 mg/kg, 80 mg/kg, or 160 mg/kg (q.d. × 4 per week) causes inhibition of tumor growth by 48%, 57%, 82.2%, or 80.0%, respectively [1].
Enzyme inhibitor
This broad-spectrum histone deacetylase inhibitor (FW = 394.48 g/mol; CASs = 783355-60-2, 783356-67-2 (HCl)); Solubility: 80 mg/mL DMSO; <1 mg/mL Water; Formulated in 30% HP-cyclodextrin in water), also known as CRA-024781 and systematically as 3-((dimethylamino)methyl)- N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide, is a novel broad-spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively. PCI-24781 treatment causes dosedependent accumulation of both acetylated histones and acetylated tubulin in HCT116 or DLD-1 cells. It also induces expression of p21 and leads to PARP cleavage and accumulation of the γH2AX.
target
HDAC1
References
[1]. buggy jj, cao za, bass ke, et al. cra-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. mol cancer ther, 2006, 5(5): 1309-1317..
CRA-02478 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
View Lastest Price from CRA-02478 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-29 | Abexinostat
783355-60-2
|
US $33.00-109.00 / mg | 98.39% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-29 | Abexinostat
783355-60-2
|
US $33.00-109.00 / mg | 98.39% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-30 | Abexinostat
783355-60-2
|
US $33.00-72.00 / mg | 98.39% | 10g | TargetMol Chemicals Inc. |
-
- Abexinostat
783355-60-2
- US $33.00-109.00 / mg
- 98.39%
- TargetMol Chemicals Inc.
-
- Abexinostat
783355-60-2
- US $33.00-109.00 / mg
- 98.39%
- TargetMol Chemicals Inc.
-
- Abexinostat
783355-60-2
- US $33.00-72.00 / mg
- 98.39%
- TargetMol Chemicals Inc.
