4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine
- CAS No.
- 1979-96-0
- Chemical Name:
- 4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine
- Synonyms
- 4,6-Dichloro-2-(Methylthio)-5-nitropyriMidine;2-Methylthio-4,6-dichloro-5-nitro-pyriMidine;Pyrimidine, 4,6-dichloro-2-(methylthio)-5-nitro-;4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine;4,6-Dichloro-2-(methylthio)-5-nitropyrimidine 98%;4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine-3;4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine ISO 9001：2015 REACH
- CBNumber:
- CB12508624
- Molecular Formula:
- C5H3Cl2N3O2S
- Molecular Weight:
- 240.07
- MDL Number:
- MFCD02323208
- MOL File:
- 1979-96-0.mol
- MSDS File:
- SDS
| Melting point | 61 °C |
|---|---|
| Boiling point | 360.4±37.0 °C(Predicted) |
| Density | 1.70±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -8.04±0.39(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C5H3Cl2N3O2S/c1-13-5-8-3(6)2(10(11)12)4(7)9-5/h1H3 |
| InChIKey | GHAWBARMICSLQS-UHFFFAOYSA-N |
| SMILES | C1(SC)=NC(Cl)=C([N+]([O-])=O)C(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H302-H335 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HS Code | 2933599590 |
4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR307014 | 4,6-Dichloro-2-(methylthio)-5-nitropyrimidine ≥95% | 1979-96-0 | 250mg | $35 | 2026-06-04 | Buy |
| Apolloscientific | OR307014 | 4,6-Dichloro-2-(methylthio)-5-nitropyrimidine ≥95% | 1979-96-0 | 1g | $45 | 2026-06-04 | Buy |
| Apolloscientific | OR307014 | 4,6-Dichloro-2-(methylthio)-5-nitropyrimidine ≥95% | 1979-96-0 | 5g | $134 | 2026-06-04 | Buy |
| Synthonix | D40612 | 4,6-Dichloro-2-(methylthio)-5-nitropyrimidine 98% | 1979-96-0 | 250mg | $17 | 2026-05-06 | Buy |
| Synthonix | D40612 | 4,6-Dichloro-2-(methylthio)-5-nitropyrimidine 98% | 1979-96-0 | 1g | $23 | 2026-05-06 | Buy |
4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine Chemical Properties, Uses, Production
Uses
4,6-Dichloro-2-(methylthio)-5-nitro-pyrimidine is a useful synthetic intermediate. It is used to prepare Cathepsin K inhibition SAR. It is also used to synthesize GS39783 (G797150) which is an allosteric positive modulator of GABAB receptors.
Synthesis
1979-97-1
1979-96-0
Step 2: 4,6-Dihydroxy-2-methylthio-5-nitropyrimidine (9.30 g, 45.81 mmol) was mixed with phosphorus trichloride (40 mL) and diethylaniline (12 mL) and the reaction was carried out at reflux for 1 hour. Upon completion of the reaction, the reaction mixture was partially evaporated, followed by slow pouring of the remaining liquid into ice water to precipitate a brown solid. The solid product was collected by filtration and washed well with cold water. The resulting solid was dried under vacuum to afford 4,6-dichloro-2-methylthio-5-nitropyrimidine (10.5 g, 95% yield) as a brown solid. Low resolution mass spectra (LRMS) of the product showed m/z = 240 (corresponding to the [M + H]+ ion of C5H3Cl2N3O2S). Nuclear magnetic resonance (NMR) spectral analysis showed results consistent with the structure of the target compound.
References
[1] Patent: US2007/270433, 2007, A1. Location in patent: Page/Page column 51
[2] Patent: US2008/4253, 2008, A1. Location in patent: Page/Page column 13
[3] Patent: US2009/156599, 2009, A1. Location in patent: Page/Page column 12
[4] Patent: WO2013/68438, 2013, A1. Location in patent: Page/Page column 29-30
[5] Patent: US2010/143301, 2010, A1. Location in patent: Page/Page column 45-46
4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine Preparation Products And Raw materials
Raw materials
Preparation Products
4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lianyungang City and Rui Technology Co., Ltd. | 015162260526; 15162260526 | sales@henrychem.com | China | 300 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| JIANGYIN CANAL PHARMTECH CO.,LIMITED. | +86-18921203887 | sales@canalpharm.net | China | 288 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hunan HuaTeng Pharmaceutical Co., Ltd., | 400-8592883 15367835770 | sales@huatengsci.com | China | 5869 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14959 | 55 |
View Latest Price from 4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-20 | 4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine
1979-96-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-03-24 | 4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine
1979-96-0
|
$3.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- 4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine
1979-96-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine
1979-96-0
- $3.00
- 98%
- Career Henan Chemical Co
