10Panx
- CAS No.
- 955091-53-9
- Chemical Name:
- 10Panx
- Synonyms
- 10Panx;Pannexin-1、Panx1;10Panx1 trifluoroacetate salt;10Panx, gap junction blocking peptide;Trp Arg Gln Ala Ala Phe Val Asp Ser Tyr;Pannexin-1 (Panx1), Mimetic Blocking Peptide - 1 mg;L-Tyrosine, L-tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-;L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-Alpha-aspartyl-L-seryl-L-tyrosine TFA Salt
- CBNumber:
- CB12522406
- Molecular Formula:
- C58H79N15O16
- Molecular Weight:
- 1242.36
- MDL Number:
- MFCD09842372
- MOL File:
- 955091-53-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 10Panx1 trifluoroacetate salt ≥98% (HPLC) | SML2152 | 1MG | $162 |
| 10Panx ~96%(HPLC) | 254341 | 1mg | $389 |
| L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-Alpha-aspartyl-L-seryl-L-tyrosine TFA Salt | TRC-T895400-1MG | 1mg | $72 |
| 10Panx | PP50791 | 10mg | $150 |
| 10Panx | PP50791 | 50mg | $653 |
| Density | 1.48±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥124.2 mg/mL in DMSO; insoluble in EtOH; ≥4.26 mg/mL in H2O with ultrasonic |
| form | solid |
| pka | 3.05±0.10(Predicted) |
| color | White to off-white |
| Water Solubility | Soluble to 1 mg/ml in water |
| Sequence | Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr |
| InChIKey | JCJASTVQGSKHKZ-QZHJRRRASA-N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
10Panx price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2152 | 10Panx1 trifluoroacetate salt ≥98% (HPLC) | 955091-53-9 | 1MG | $162 | 2026-04-30 | Buy |
| Usbiological | 254341 | 10Panx ~96%(HPLC) | 955091-53-9 | 1mg | $389 | 2026-06-03 | Buy |
| TRC | TRC-T895400-1MG | L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-Alpha-aspartyl-L-seryl-L-tyrosine TFA Salt | 955091-53-9 | 1mg | $72 | 2026-06-03 | Buy |
| Biosynth | PP50791 | 10Panx | 955091-53-9 | 10mg | $150 | 2026-06-04 | Buy |
| Biosynth | PP50791 | 10Panx | 955091-53-9 | 50mg | $653 | 2026-06-04 | Buy |
10Panx Chemical Properties,Uses,Production
Uses
L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine is a connexin mimetic peptide that inhibits pannexin-1 gap junctions.
Biological Activity
10panx is a mimetic inhibitory peptide of panx1, which is a mammalian protein ectopically expressed to function as a hemi-channel, that readily and reversibly inhibits the panx1 currents. 10panx has attracted increasing attention as it allows scientists readily and reliably to examine inhibition of panx1 in cells where efficient and consistent delivery of sirna is highly difficult. according to results of multiple previous studies, 10panx selectively inhibits p2x7r-induced dye uptake without altering other aspects of r2x7r activation and atp-evoked membrane currents, constitutive dye-uptake and hemichannel-like currents that are induced by the overexpression of panx1, and atp-mediated il-1β release.pablo pelegrin and annmarie surprenant. pannexin-1 mediates large pore formation and interleukin-1β release by the atp-gated p2x7 receptor. the embo journal (2006) 25, 5071-5082
in vivo
10Panx (300 μM; intrathecal injection; single dose; 1 h pretreatment) completely abolished NMDA- and BzATP-induced mechanical hyperalgesia and C-reflex wind-up potentiation in a neuropathic rat model[3].
storage
Store at -20°C
10Panx Preparation Products And Raw materials
Raw materials
Preparation Products
10Panx Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4734 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7858 | 58 |
