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N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine structure

CAS No.: 444731-74-2

Chemical Name:: N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

Synonyms: BNKY007-PZ01;Pazopanib Impurity 20;Pazopanil impurity 12;2H-indazol-6aMine,2,3-diMethyl.HCl(1:1);N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-;6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole;N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine

CBNumber:: CB12526161

Molecular Formula:: C13H12ClN5

Molecular Weight:: 273.72

MDL Number:: MFCD17014818

MOL File:: 444731-74-2.mol

MSDS File:: SDS

Last updated:2025-07-28 09:52:40

Product description	Number	Pack Size	Price
N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine	C380080	1g	$175
N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	FC32848	250mg	$315
N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine 95+%	095743	250mg	$439
N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	FC32848	500mg	$525
N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	X3179	5g	$728
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N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Properties

Melting point	>216oC (dec.)
Boiling point	550.0±35.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Hygroscopic, Refrigerator, under inert atmosphere
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	2.56±0.30(Predicted)
color	Pale Orange to Light Brown
Stability	Hygroscopic
InChI	InChI=1S/C13H12ClN5/c1-8-10-4-3-9(7-11(10)18-19(8)2)16-12-5-6-15-13(14)17-12/h3-7H,1-2H3,(H,15,16,17)
InChIKey	SCUMWVJJSLLWHQ-UHFFFAOYSA-N
SMILES	N1=C2C(C=CC(NC3C=CN=C(Cl)N=3)=C2)=C(C)N1C

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C380080	N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine	444731-74-2	1g	$175	2021-12-16	Buy
Biosynth Carbosynth	FC32848	N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	444731-74-2	250mg	$315	2021-12-16	Buy
Matrix Scientific	095743	N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine 95+%	444731-74-2	250mg	$439	2021-12-16	Buy
Biosynth Carbosynth	FC32848	N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	444731-74-2	500mg	$525	2021-12-16	Buy
AK Scientific	X3179	N-(2-Chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine	444731-74-2	5g	$728	2021-12-16	Buy

Product number	Packaging	Price	Buy
C380080	1g	$175	Buy
FC32848	250mg	$315	Buy
095743	250mg	$439	Buy
FC32848	500mg	$525	Buy
X3179	5g	$728	Buy

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Chemical Properties,Uses,Production

Uses

N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine (N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine) is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Application

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine is a valuable organic compound that could be used to synthesize N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, N- (2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, and others.

Synthesis

2,3-dimethyl-6-amino-2H- indazole 5.00g,2,4-Dichloropyrimidine 13.9g and sodium bicarbonate 10.4g were dissolved in 100mL absolute ethanol and heated to 79°C.After refluxing for 4 h, cool to room temperature and filter. The cake was washed well with ethyl acetate, and the filtrate was collected. Concentrate under reduced pressure, remove the solvent, and fully beat with ethyl acetate and filter to give an off-white solid. Recrystallization from methanol gave 7.64 g of product N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine as a white solid, yield: 90.0%.

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine synthesis

Synthesis of N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine from 2,4-Dichloropyrimidine and 2,3-DIMETHYL-2H-INDAZOL-6-AMINE

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Preparation Products And Raw materials

Raw materials

2,3-DIMETHYL-2H-INDAZOL-6-AMINE 2,3-dimethyl-2H-indazol-6-amine hydrochloride 2,4-Dichloropyrimidine

Preparation Products

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Suppliers

Global( 147)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Yangzhou Qinyuan Pharmatech Co.,ltd	+86-18752526868 +86-18752526868	jennysun@yzqyyykj.com	China	80	58
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
BIONNA MEDICINE CO.,LTD	58
Yangzhou Qinyuan Pharmatech Co.,ltd	58
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
Shenzhen Excellent Biotech Co., Ltd.	58
Shanghai Yingrui Biopharma Co.,Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58

How to prepare N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine?
N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine can be prepared from 2-ethylaniline by nitration, cyclization and m....
Jul 28，2025

View Lastest Price from N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine 444731-74-2	US $1.10 / g	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2024-10-31	N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine 444731-74-2	US $0.00 / g	10g	98%	10tons	Yangzhou Qinyuan Pharmatech Co.,ltd
2019-07-06	2H-Indazol-6-amine,N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl- 444731-74-2	US $1.00 / KG	1KG	99%	20tons	Career Henan Chemical Co

N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
444731-74-2
US $1.10 / g
99.0% Min
Dideu Industries Group Limited

N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
444731-74-2
US $0.00 / g
98%
Yangzhou Qinyuan Pharmatech Co.,ltd

2H-Indazol-6-amine,N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl-
444731-74-2
US $1.00 / KG
99%
Career Henan Chemical Co

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Spectrum

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine(444731-74-2)¹HNMR

444731-74-2(N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine)Related Search:

Pazopanib Related Compound 3 (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Pazopanib Impurity 9 N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

2,3-dimethyl-6-nitro-2H-indazole Pazopanib Pazopanib-d6 2,3-dimethyl-2H-indazol-6-amine hydrochloride Pazopanib Related Compound 2

1,3-Dimethyl-6-nitro-1H-indazole 2-Methyl-5-nitrobenzenesulfonamide 3-AMINO-4-METHYLBENZENESULFONAMIDE 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)

1,3-DiMethyl-6-aMino-1H-indazole 4(1H)-Pyrimidinone, 2-chloro- (9CI) Pazopanib Impurity 10

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N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine 2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl- N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine 2H-indazol-6aMine,2,3-diMethyl.HCl(1:1) 6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole Pazopanib Impurity 20 BNKY007-PZ01 N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine ISO 9001：2015 REACH N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine N,2,3-trimethyl-N-(2-((4-methyl-3-sulfamoylphenyl)amino)pyrimidin-4-yl)-2H-indazol-6-amine oxidee Pazopanil impurity 12 444731-74-2 44731-74-2