ABT-492
- CAS No.
- 189279-58-1
- Chemical Name:
- ABT-492
- Synonyms
- Delafloxacin;Delafloxacine;Delafloxacin Impurity;WQ3034;CS-711;RX-3341;ABT-492;CS-2335;Delafloxacinum;ABT492/ABT-492
- CBNumber:
- CB12561456
- Molecular Formula:
- C18H12ClF3N4O4
- Molecular Weight:
- 440.76
- MDL Number:
- MFCD09955301
- MOL File:
- 189279-58-1.mol
| Melting point | 238-241℃ |
|---|---|
| Boiling point | 698.5±55.0 °C(Predicted) |
| Density | 1.796 |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Very Slightly, Heated, Sonicated) |
| pka | 5.49±0.50(Predicted) |
| form | powder |
| color | white to beige |
| CAS DataBase Reference | 189279-58-1 |
| FDA UNII | 6315412YVF |
| ATC code | J01MA23 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
ABT-492 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1869 | Delafloxacin ≥98% (HPLC) | 189279-58-1 | 5MG | $102 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1869 | Delafloxacin ≥98% (HPLC) | 189279-58-1 | 25MG | $413 | 2023-06-20 | Buy |
| Cayman Chemical | 20314 | Delafloxacin 98% | 189279-58-1 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 20314 | Delafloxacin 98% | 189279-58-1 | 1mg | $25 | 2021-12-16 | Buy |
| Cayman Chemical | 20314 | Delafloxacin 98% | 189279-58-1 | 10mg | $82 | 2024-03-01 | Buy |
ABT-492 Chemical Properties,Uses,Production
Uses
Delafloxacin is a potent agent and broad-spectrum anionic fluoroquinolone against Streptococcus pneumoniae and diverse group of pathogens.
Biochem/physiol Actions
Delafloxacin is a fluoroquinolone antibiotic active against both Gram-negative and Gram-positive bacteria such as MRSA. Delafloxacin targets both DNA gyrase and topoisomerase IV, inhibiting DNA synthesis. Unlike most fluoroquinolones, delafloxacin is weakly acidic, which increases its potency in an acidic environments such as those existing in inflammatory cells and in skin and soft tissue infections. Delafloxacin shows good activity against most fluoroquinolone-resistant strains.
in vivo
Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log10 CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log10 kill from initial burden for all S. aureus strains[1].
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)[1].
| Animal Model: | Mice with a neutropenic murine lung infection model (four S. aureus , four S. pneumoniae, and four K. pneumoniae strains)[1] |
| Dosage: | The total daily doses vary from 0.156 to 640 mg/kg/24 h |
| Administration: | 0.03 to 160 mg/kg are administered every 6 h (q6h) to infected mice by subcutaneous injection |
| Result: | Inhibited S. aureus strains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively. Inhibited S. pneumoniae strains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively. Inhibited K. pneumonia strains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively. |
| Animal Model: | Neutropenic mice[1] |
| Dosage: | 2.5, 10, 40, and 160 mg/kg; 0.2 mL |
| Administration: | Subcutaneous injection; 24 h |
| Result: | The maximum drug concentrations (Cmax) concentrations ranged from 2 to 71 mg/L. AUC0-∞ values ranged from 2.8 to 152 mg?h/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t1/2) ranged from 0.7 to 1 h. |
IC 50
Quinolone
ABT-492 Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| hebei hongtan Biotechnology Co., Ltd | +852-6619 3215 +86-17731935328 | sales03@chemcn.cn | China | 970 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 485 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Klong Industrial Co., Ltd | 0086-519-68231162 | info@klongchem.com | CHINA | 131 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
View Lastest Price from ABT-492 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-07 | Delafloxacin
189279-58-1
|
US $39.00-153.00 / mg | 99.81% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-03-04 | Delafloxacin API
189279-58-1
|
US $50.00-30.00 / KG | 1KG | 99.9% | 500 | hebei hongtan Biotechnology Co., Ltd | |
 |
2025-03-04 | Delafloxacin
189279-58-1
|
US $15.00-1.00 / kg | 1kg | 99.9% | 500 | hebei hongtan Biotechnology Co., Ltd |
-
- Delafloxacin
189279-58-1
- US $39.00-153.00 / mg
- 99.81%
- TargetMol Chemicals Inc.
-
- Delafloxacin API
189279-58-1
- US $50.00-30.00 / KG
- 99.9%
- hebei hongtan Biotechnology Co., Ltd
-
- Delafloxacin
189279-58-1
- US $15.00-1.00 / kg
- 99.9%
- hebei hongtan Biotechnology Co., Ltd