4-Hydroxytolbutamide
- CAS No.
- 5719-85-7
- Chemical Name:
- 4-Hydroxytolbutamide
- Synonyms
- HYDROXY TOLBUTAMIDE;Tolbutamide Hydroxy;4-HYDROXYTOLBUTAMIDE;Tolbutamide Impurity 4;hydroxymethyltolbutamide;HydroxyMethylcarbutaMide;HydroxyMethylcarbutaMide Impurity;4-Hydroxytolbutamide solution ;4-Hydroxytolbutamide Solution, 100ppm;1-Butyl-3-(p-hydroxyMethylphenyl)sulfonylurea
- CBNumber:
- CB1258804
- Molecular Formula:
- C12H18N2O4S
- Molecular Weight:
- 286.35
- MDL Number:
- MFCD00144466
- MOL File:
- 5719-85-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Hydroxytolbutamide ≥98% (HPLC) | UC160 | 5mg | $896 |
| 4-hydroxy Tolbutamide ≥98% | 10008520 | 1mg | $41 |
| 4-hydroxy Tolbutamide ≥98% | 10008520 | 5mg | $153 |
| 4-Hydroxytolbutamide ≥98% (HPLC) | UC160 | 10mg | $1660 |
| 4-hydroxy Tolbutamide ≥98% | 10008520 | 10mg | $286 |
| More product size | |||
| Melting point | 100-102 °C |
|---|---|
| Density | 1.268±0.06 g/cm3(Predicted) |
| Flash point | 2℃ |
| storage temp. | 2-8°C |
| solubility | ethanol: 12 mg/mL |
| pka | 4.96±0.10(Predicted) |
| form | Solid |
| color | white |
| InChI | 1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16) |
| InChIKey | SJRHYONYKZIRPM-UHFFFAOYSA-N |
| SMILES | CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1 |
| FDA UNII | 52K8J94779 |
| UNSPSC Code | 12161501 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H302+H312+H332-H319 |
| Precautionary statements | P210-P261-P302+P352+P312-P304+P340+P312-P337+P313-P403+P235 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | F,Xn |
| Risk Statements | 11-20/21/22-36 |
| Safety Statements | 16-36/37-24/25 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 3 |
| HS Code | 29350090 |
| Storage Class | 11 - Combustible Solids |
4-Hydroxytolbutamide price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | UC160 | 4-Hydroxytolbutamide ≥98% (HPLC) | 5719-85-7 | 5mg | $896 | 2024-03-01 | Buy |
| Cayman Chemical | 10008520 | 4-hydroxy Tolbutamide ≥98% | 5719-85-7 | 1mg | $41 | 2024-03-01 | Buy |
| Cayman Chemical | 10008520 | 4-hydroxy Tolbutamide ≥98% | 5719-85-7 | 5mg | $153 | 2024-03-01 | Buy |
| Sigma-Aldrich | UC160 | 4-Hydroxytolbutamide ≥98% (HPLC) | 5719-85-7 | 10mg | $1660 | 2024-03-01 | Buy |
| Cayman Chemical | 10008520 | 4-hydroxy Tolbutamide ≥98% | 5719-85-7 | 10mg | $286 | 2024-03-01 | Buy |
4-Hydroxytolbutamide Chemical Properties,Uses,Production
Description
4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs.
Chemical Properties
White Solid
Uses
A metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes
Uses
4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.
Definition
ChEBI: A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.
References
[1] J O MINERS D J B. Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9.[J]. Methods in enzymology, 1996, 272: 139-145. DOI: 10.1016/s0076-6879(96)72017-7
[2] VAN NGUYEN Fawzy E Michael Espiritu. Development and validation of a sensitive and specific LC-MS/MS cocktail assay for CYP450 enzymes: Application to study the effect of catechin on rat hepatic CYP activity.[J]. Biomedical Chromatography, 2020, 34 3: e4789. DOI: 10.1002/bmc.4789
4-Hydroxytolbutamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3992 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7245 | 62 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Artis Chemistry (Shanghai) Co. Ltd. | 86-21-60936353 | China | 335 | 58 |
View Lastest Price from 4-Hydroxytolbutamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | 4-Hydroxytolbutamide
5719-85-7
|
US $142.00-987.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- 4-Hydroxytolbutamide
5719-85-7
- US $142.00-987.00 / mg
- TargetMol Chemicals Inc.
