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17(S)-HpDoHE

CAS No.
123673-33-6
Chemical Name:
17(S)-HpDoHE
Synonyms
17(S)-HpDHA;17(S)-HpDoHE;BNHQALRBDJVUQB-YTQNUIGOSA-N;17(S)-HpDHA(solution in ethanol);17(S)-hydroperoxy-4(E),7(Z),10(Z),13(Z),15(Z),19(Z)-DHA;17(S)-hydroperoxy-4(E),7(Z),10(Z),13(Z),15(Z),19(Z)-Docosahexaenoic acid;4,7,10,13,15,19-Docosahexaenoic acid, 17-hydroperoxy-, (4Z,7Z,10Z,13Z,15E,17S,19Z)-
CBNumber:
CB12589933
Molecular Formula:
C22H32O4
Molecular Weight:
360.49
MDL Number:
MFCD18428009
MOL File:
123673-33-6.mol
MSDS File:
SDS
Last updated:2026-07-28 08:09:04

17(S)-HpDoHE Properties

Boiling point 531.121±50.00 °C(Press: 760.00 Torr)(predicted)
Density 1.023±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Store at -20°C
solubility DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka 4.581±0.10(predicted)

17(S)-HpDoHE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13185 17(S)-HpDHA ≥98% 123673-33-6 25μg $146 2026-04-30 Buy
Cayman Chemical 13185 17(S)-HpDHA ≥98% 123673-33-6 50μg $277 2026-04-30 Buy
Cayman Chemical 13185 17(S)-HpDHA ≥98% 123673-33-6 100μg $523 2026-04-30 Buy
Cayman Chemical 13185 17(S)-HpDHA ≥98% 123673-33-6 250μg $947 2024-03-01 Buy
Product number Packaging Price Buy
13185 25μg $146 Buy
13185 50μg $277 Buy
13185 100μg $523 Buy
13185 250μg $947 Buy

17(S)-HpDoHE Chemical Properties, Uses, Production

Description

17(S)-HpDHA is a mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, human glial cells, and mouse brain. 17(S)-HpDHA is generally reduced to 17(S)-HDHA , a compound that serves as a precursor to 17(S)-resolvins. 17(S)-HDHA has been shown to inhibit TNF-α-induced interleukin-1β expression in human glioma cells and inhibit TNF-α-induced leukocyte trafficking to the murine air pouch.

Uses

17(S)-HpDHA is the main 15-Lipoxygenase (LOX) isoenzyme: h15-LOX-1 and h15-LOX-2 and docosahexaenoic acid (DHA). product. 17(S)-HpDHA negatively regulates epoxide synthesis via allosteric regulation. 17(S)-HpDHA also inhibits platelet aggregation with an EC50 of approximately 1 μM[1].

Definition

ChEBI: (4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid is a docosanoid that is (4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying a hydroperoxy substituent at position 17S. It has a role as a mouse metabolite. It is a docosanoid, a long-chain fatty acid and a hydroperoxy polyunsaturated fatty acid. It is functionally related to an all-cis-docosa-4,7,10,13,16,19-hexaenoic acid. It is a conjugate acid of a (4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoate.

References

[1] Tsai WC, et al. In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. Biochemistry. 2021 Jun 8;60(22):1741-1754. DOI:10.1021/acs.biochem.0c00931

17(S)-HpDoHE Preparation Products And Raw materials

Raw materials

Preparation Products

17(S)-HpDoHE Suppliers

Global Suppliers ( 29)
Supplier Tel Email Country ProdList Advantage
Yichang Zhongyitai Trading Co., Ltd. 0717-6449896 13886658719 root@zhongyitai.com China 1978 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7982 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
17(S)-HpDoHE 17(S)-HpDHA BNHQALRBDJVUQB-YTQNUIGOSA-N 4,7,10,13,15,19-Docosahexaenoic acid, 17-hydroperoxy-, (4Z,7Z,10Z,13Z,15E,17S,19Z)- 17(S)-hydroperoxy-4(E),7(Z),10(Z),13(Z),15(Z),19(Z)-Docosahexaenoic acid 17(S)-hydroperoxy-4(E),7(Z),10(Z),13(Z),15(Z),19(Z)-DHA 17(S)-HpDHA(solution in ethanol) 123673-33-6