Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>DAz-1

DAz-1

DAz-1 Structure
DAz-1 structure
CAS No.
1112977-84-0
Chemical Name:
DAz-1
Synonyms
DAZ;SPGY;DAz-1;N-(3-Azidopropyl)-3,5-dioxocyclohexanecarboxamide;N-(3-azidopropyl)-3,5-dioxocyclohexane-1-carboxamide
CBNumber:
CB12590807
Molecular Formula:
C10H14N4O3
Molecular Weight:
238.243
MDL Number:
MOL File:
1112977-84-0.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:40
Request For Quotation

DAz-1 Properties

storage temp. Store at -20°C
solubility DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 20 mg/ml
form A crystalline solid

DAz-1 price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13173 DAz-1 ≥98% 1112977-84-0 1mg $109 2026-04-30 Buy
Cayman Chemical 13173 DAz-1 ≥98% 1112977-84-0 5mg $517 2026-04-30 Buy
Cayman Chemical 13173 DAz-1 ≥98% 1112977-84-0 10mg $981 2026-04-30 Buy
ChemScene CS-0085945 DAz-1 1112977-84-0 1mg $448 2026-06-04 Buy
ChemScene CS-0085945 DAz-1 1112977-84-0 5mg $1120 2026-06-04 Buy
Product number Packaging Price Buy
13173 1mg $109 Buy
13173 5mg $517 Buy
13173 10mg $981 Buy
CS-0085945 1mg $448 Buy
CS-0085945 5mg $1120 Buy

DAz-1 Chemical Properties, Uses, Production

Description

Redox-sensitive cysteine residues in proteins may function as sensors of reactive oxygen species (ROS) and also serve as molecular switches, activating or deactivating proteins, following a change in oxidation state. Modification of protein function through the reversible oxidation of cysteine is emerging as a biologically relevant signal transduction mechanism. Sulfenic acid is the initial oxidation product of cysteine by relatively mild oxidizing agents such as hydrogen peroxide. Sulfenic acid can be reduced back to the free thiol or be further oxidized to sulfinic and sulfonic acids. DAz-1 is a cell-permeable chemical probe that reacts specifically with sulfenic acid-modified proteins. The azido group of DAz-1 provides a method for selective conjugation to phosphine- or alkynyl- derivatized reagents, such as biotin or various fluorophores, for subsequent analysis of the labeled proteins. DAz-1 is a less sensitive probe for sulfenic acid detection compared to its analog DAz-2 .

Uses

DAz-1 is a sulfonic acid probe for living cells, which can directly detect sulfonic acid-modified proteins in living cells and is cell-permeable[1].

References

[1] Leonard SE, et al. Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells. ACS Chem Biol. 2009 Sep 18;4(9):783-99. DOI:10.1021/cb900105q

DAz-1 Preparation Products And Raw materials

Raw materials

Preparation Products

DAz-1 Suppliers

Global Suppliers ( 26)
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
Hubei Aiputi Bioengineering Co., Ltd. 17762444226 d17762444226@163.com China 2400 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
Hubei Aiputi Bioengineering Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

1112977-84-0 (DAz-1) Related Search:

WYneO BCN-E-BCN DAz-2 Phosphonium, [2-oxo-2-(2-propyn-1-ylamino)ethyl]triphenyl-, bromide (1:1) S-Phenylsulfonylcysteine
Doxorubicin hydrochloride

1of2

DAz-1 N-(3-azidopropyl)-3,5-dioxocyclohexane-1-carboxamide N-(3-Azidopropyl)-3,5-dioxocyclohexanecarboxamide DAZ SPGY 1112977-84-0