2,4-Dichloro-5-fluoro-6-methylpyrimidine
- CAS No.
- 954220-98-5
- Chemical Name:
- 2,4-Dichloro-5-fluoro-6-methylpyrimidine
- Synonyms
- Pyrimidine, 2,4-dichloro-5-fluoro-6-methyl-
- CBNumber:
- CB12617674
- Molecular Formula:
- C5H3Cl2FN2
- Molecular Weight:
- 181
- MDL Number:
- MFCD09863051
- MOL File:
- 954220-98-5.mol
| Product description | Number | Pack Size | Price |
| 2,4-dichloro-5-fluoro-6-methylpyrimidine | D400710 | 100mg | $240 |
| 2,4-DICHLORO-5-FLUORO-6-METHYLPYRIMIDINE 95.00% | HCH0357306 | 5MG | $496.69 |
| 2,4-dichloro-5-fluoro-6-methylpyrimidine | 4456AQ | 100mg | $227.6 |
| 2,4-Dichloro-5-fluoro-6-methylpyrimidine 95% | A100355 | 1g | $235 |
| 2,4-Dichloro-5-fluoro-6-methylpyrimidine 95% | A100355 | 100mg | $67 |
| Boiling point | 225.1±35.0 °C(Predicted) |
|---|---|
| Density | 1.504±0.06 g/cm3(Predicted) |
| storage temp. | -20°C, stored under nitrogen |
| pka | -3.23±0.39(Predicted) |
| Appearance | Colorless to light yellow Solid-Liquid Mixture |
| InChI | InChI=1S/C5H3Cl2FN2/c1-2-3(8)4(6)10-5(7)9-2/h1H3 |
| InChIKey | IYGLMCCNOPCDCR-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(C)=C(F)C(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H302-H319-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P |
2,4-Dichloro-5-fluoro-6-methylpyrimidine price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D400710 | 2,4-dichloro-5-fluoro-6-methylpyrimidine | 954220-98-5 | 100mg | $240 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0357306 | 2,4-DICHLORO-5-FLUORO-6-METHYLPYRIMIDINE 95.00% | 954220-98-5 | 5MG | $496.69 | 2021-12-16 | Buy |
| AK Scientific | 4456AQ | 2,4-dichloro-5-fluoro-6-methylpyrimidine | 954220-98-5 | 100mg | $227.6 | 2021-12-16 | Buy |
| Ambeed | A100355 | 2,4-Dichloro-5-fluoro-6-methylpyrimidine 95% | 954220-98-5 | 1g | $235 | 2021-12-16 | Buy |
| Ambeed | A100355 | 2,4-Dichloro-5-fluoro-6-methylpyrimidine 95% | 954220-98-5 | 100mg | $67 | 2021-12-16 | Buy |
2,4-Dichloro-5-fluoro-6-methylpyrimidine Chemical Properties,Uses,Production
Synthesis
75-16-1
2927-71-1
954220-98-5
The general procedure for the synthesis of 2,4-dichloro-5-fluoro-6-methylpyrimidines from methylmagnesium bromide and 2,4-dichloro-5-fluoropyrimidines is as follows (adapted from the literature methodology: M. Butters, J. Ebbs, S.P. Green, J. MacRae, M.C. Morland, C.W. Murtiashaw and A.J. Pettman, Organic Process Research & Development 2001, 5, 28-36): to a solution of 3.0 M methylmagnesium bromide in tetrahydrofuran (20 mL) in ether (15 mL, 45 mmol, 1.5 eq.) was added 2,4-dichloro-5-fluoropyrimidine (5 g, 30 mmol, 1 equivalent) in 1,2-dimethoxyethane, keeping the temperature below 15 °C while maintaining a volume of 20 mL. The resulting solution was stirred at 15 °C for 1 h and then cooled to 0 °C. The reaction mixture was then cooled to 0 °C. A solution of triethylamine (4.17 mL, 30 mmol, 1 eq.) in tetrahydrofuran (10 mL) was slowly added to the reaction mixture, maintaining an internal temperature of about 5 °C, followed by a solution of iodine (30 mmol, 1 eq.) in tetrahydrofuran (10 mL). The reaction mixture was quenched with water, warmed to room temperature, extracted with ethyl acetate and concentrated. The crude product was purified by silica gel column chromatography (dichloromethane/hexane) to afford 2,4-dichloro-5-fluoro-6-methylpyrimidine in 74% yield.
References
[1] Patent: WO2009/131974, 2009, A1. Location in patent: Page/Page column 88
[2] Patent: WO2012/138590, 2012, A1. Location in patent: Page/Page column 71
[3] Patent: WO2018/118842, 2018, A1. Location in patent: Paragraph 0505-0508
[4] Patent: WO2014/13076, 2014, A1. Location in patent: Page/Page column 43
[5] Patent: WO2014/66132, 2014, A1. Location in patent: Page/Page column 16
2,4-Dichloro-5-fluoro-6-methylpyrimidine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2,4-Dichloro-5-fluoro-6-methylpyrimidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Compound Net Biotechnology Inc. | +8615303909093 | sales@compound-net.com | China | 2914 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shandong Baiqi Biomedical Co. Ltd | 0536-8998390; 13173160180 | sales@baiqpharm.com | China | 594 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 42446 | 60 |
| BioPharmaMatrix,Inc. | 0510-86010668 | sales@biopharmamatrix.com | China | 4721 | 55 |
| Shanghai Pingguo Pharmaceutical Co., Ltd. | 021-20432229 | 2412110556@qq.com | China | 6017 | 55 |
| Aikon International Limited | 025-58859352 18068836627 | sales01@aikonchem.com | China | 16027 | 58 |
| Nantong Kaisheng Biotechnology Co., Ltd. | 13951303301 | 2084934672@qq.com | China | 716 | 58 |
