Metoclopramide monohydrochloride monohydrate
- CAS No.
- 54143-57-6
- Chemical Name:
- Metoclopramide monohydrochloride monohydrate
- Synonyms
- MetoclopraMide HCI;Metoclopramide HCl monohydrate;Metoclopramide hydrochloride CRS;MetocL;Annavar;Gastromax;GastreseL.A;Levohypropizine;Gastrobidcontinus;opramide hydrochL
- CBNumber:
- CB1262047
- Molecular Formula:
- C14H25Cl2N3O3
- Molecular Weight:
- 354.27
- MDL Number:
- MFCD00150634
- MOL File:
- 54143-57-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Metoclopramide hydrochloride | 1440808 | 500mg | $455 |
| Metoclopramide Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | PHR1132 | 1 g | $105 |
| Metoclopramide Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | PHR1132 | 1g | $97.5 |
| Metoclopramide hydrochloride European Pharmacopoeia (EP) Reference Standard | M1825000 | M1825000 | $150 |
| Metoclopramide hydrochloride hydrate | FA61507 | 50g | $255.5 |
| More product size | |||
| Melting point | 182.5-184° |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | It is very soluble in water, easily soluble in ethyl alcohol, slightly soluble in dichloromethane. |
| Sensitive | Light Sensitive |
| BCS Class | 3 |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C14H22ClN3O2.ClH.H2O/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H;1H2 |
| InChIKey | RVFUNJWWXKCWNS-UHFFFAOYSA-N |
| SMILES | C(C1C=C(Cl)C(N)=CC=1OC)(=O)NCCN(CC)CC.Cl.O |
| CAS DataBase Reference | 54143-57-6(CAS DataBase Reference) |
| FDA UNII | W1792A2RVD |
| NCI Drug Dictionary | metoclopramide hydrochloride |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| WGK Germany | 3 |
| HS Code | 2924296000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
Metoclopramide monohydrochloride monohydrate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1440808 | Metoclopramide hydrochloride | 54143-57-6 | 500mg | $455 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR1132 | Metoclopramide Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 1 g | $105 | 2025-07-31 | Buy | |
| Sigma-Aldrich | PHR1132 | Metoclopramide Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 54143-57-6 | 1g | $97.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | M1825000 | Metoclopramide hydrochloride European Pharmacopoeia (EP) Reference Standard | 54143-57-6 | M1825000 | $150 | 2024-03-01 | Buy |
| Biosynth | FA61507 | Metoclopramide hydrochloride hydrate | 54143-57-6 | 50g | $255.5 | 2026-06-04 | Buy |
Metoclopramide monohydrochloride monohydrate Chemical Properties,Uses,Production
Originator
Primperan,Delagrange,France,1964
Uses
Dopamine receptor antagonist; antiemetic.
Uses
Metoclopramide Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological fluids by chromatography and chemiluminescence techniques.
Indications
Metoclopramide (Reglan) stimulates upper GI tract motility and has both central and peripheral actions. Centrally, it is a dopamine antagonist, an action that is important both for its often desirable antiemetic effect and other less desirable effects. Peripherally, it stimulates the release of intrinsic postganglionic stores of acetylcholine and sensitizes the gastric smooth muscle to muscarinic stimulation. The ability of metoclopramide to antagonize the inhibitory neurotransmitter effect of dopamine on the GI tract results in increased gastric contraction and enhanced gastric emptying and small bowel transit.
Definition
ChEBI: A hydrate that is the monohydrate form of metoclopramide monohydrochloride.
Manufacturing Process
The N-(diethylaminoethyl)-2-methoxy-4-aminobenzamide used as the starting
material may be prepared from o-toluidine. The o-toluidine is initially nitrated
with nitric acid to produce 4-nitro-o-toluidine. The 4-nitro-o-toluidine is then
converted to 2-hydroxy-4-nitrotoluene by heating with nitrous acid. By
reacting the resulting 2-hydroxy-4-nitrotoluene with dimethyl sulfate, 2-
methoxy-4-nitrotoluene is formed. The 2-methoxy-4-nitrotoluene is oxidized
with potassium permanganate to produce 2-methoxy-4-nitrobenzoic acid. The
latter substituted benzoic acid is treated with thionyl chloride to form 2-
methoxy-4-nitrobenzoyl chloride. A methyl ethyl ketone solution of the 2-
methoxy-4-nitrobenzoyl chloride is added over a period of about 1 hours to
a methyl ethyl ketone solution containing an equal molecular quantity of N,Ndiethylethylene diamine while stirring and maintaining the temperature
between 0°C and 5°C. The N-(diethylaminoethyl)-2-methoxy-4-
nitrobenzamide hydrochloride formed precipitates. It is filtered, washed twice
with methyl ethyl ketone, dissolved in alcohol, and reduced catalytically in an
absolute isopropyl alcohol solution to form N-(diethylaminoethyl)-2-methoxy-
4-aminobenzamide. The base is obtained by precipitating with sodium
hydroxide.
80 g (0.3mol) of N-(2-diethylaminoethyl)-2-methoxy-4-aminobenzamide are
dissolved in small portions in 150 cc of acetic acid. The mixture is cooled and
45 g (0.45 mol) of acetic anhydride are added, and the solution obtained is
heated for two hours on a water bath. After cooling, the solution is decanted
into a round-bottomed flask with a stirrer, a thermometer and a tube for
introducing the chlorine. It is stirred and the current of chlorine is passed
through, the temperature being maintained between 20°C and 25°C. The
stirring is continued for one hour after the completion of the absorption of the
chlorine.
The mixture obtained is poured into 2 liters of water and the base is
precipitated with 30% soda. The precipitated base is extracted with 400 cc of
methylene chloride. After evaporation of the solvent, the N-(2-
diethylaminoethyl)-2-methoxy-4-acetamino-5-chlorobenzamide formed
crystallizes. The melting point is 86°C to 87°C and the yield is 95%.
To obtain the corresponding amino derivative, 109 g of base are heated under
agitation in a round-bottomed flask with 300 cc of 35-36% concentrated
hydrochloric acid and 600 cc of water. It is heated on a water bath until
dissolution is complete, then maintained at boiling point for 90 minutes,
cooled, diluted with 1 liter of water, and neutralized with about 350 cc of 30%
soda. The N-(2-diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide
formed crystallizes, is centrifuged and washed in water. Its melting point is
122°C and the yield is 74%.
To obtain the corresponding dihydrochloride, the base is dissolved in absolute
alcohol (3 volumes) and to that solution is added 5 N alcoholic hydrochloric
acid. The dihydrochloride precipitates, is centrifuged and washed with alcohol.
It is a solid white material, having a melting point of 134°C to 135°C.
brand name
Maxolon (King); Reglan (Baxter Healthcare); Reglan (Robins); Reglan (Schwarz Pharma).
Therapeutic Function
Antiemetic
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Metoclopramide Hydrochloride is an antiemetic drug and is generally used for the treatment of gastrointestinal disorders. It can also exhibit sedative, extrapyrimidal, and prolactin secretion stimulation actions.
Mechanism of action
Metoclopramide is rapidly absorbed following an oral dose in a patient with intact gastric emptying. Peak plasma concentration is achieved within 40 to 120 minutes. With normal renal function, plasma half-life is about 4 hours.About 20% of an oral dose is eliminated unchanged in the urine, while 60% is eliminated as sulfate or glucuronide conjugates.
Clinical Use
Improved gastric emptying will frequently alleviate symptoms in patients with diabetic, postoperative, or idiopathic gastroparesis. Since metoclopramide also can decrease the acid reflux into the esophagus that results from slowed gastric emptying or lower esophageal sphincter pressure, the drug can be used as an adjunct in the treatment of reflux esophagitis.
Side effects
Side effects include fatigue, insomnia, and altered motor coordination. Parkinsonian side effects and acute dystonic reactions also have been reported. Metoclopramide stimulates prolactin secretion, which can cause galactorrhea and menstrual disorders. Extrapyramidal side effects seen following administration of the phenothiazines, thioxanthenes, and butyrophenones may be accentuated by metoclopramide.
Metoclopramide monohydrochloride monohydrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 143 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Hebei Jimi Trading Co., Ltd. | +86 319 5273535 | bestoneforyou@sina.com | CHINA | 287 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 1287 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | info@longyupharma.com | China | 2421 | 58 | |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
View Lastest Price from Metoclopramide monohydrochloride monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-06 | Metoclopramide hydrochloride
54143-57-6
|
1kg | 99% | 1T | Shandong Hanjiang Chemical Co., Ltd | ||
 |
2026-05-11 | Metoclopramide hydrochloride hydrate
54143-57-6
|
$53.00 | 99.33% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-15 | Metoclopramide hydrochloride
54143-57-6
|
1kg | 99.9（WhatsApp/telegram：+86 13326778444） | 10 tons（WhatsApp/telegram：+86 13326778444） | Guangdong Junhua Chemical Co., Ltd |
-
- Metoclopramide hydrochloride
54143-57-6
- 99%
- Shandong Hanjiang Chemical Co., Ltd
-
- Metoclopramide hydrochloride hydrate
54143-57-6
- $53.00
- 99.33%
- TargetMol Chemicals Inc.
-
- Metoclopramide hydrochloride
54143-57-6
- 99.9（WhatsApp/telegram：+86 13326778444）
- Guangdong Junhua Chemical Co., Ltd
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