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ChemicalBook >> CAS DataBase List >>1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine Structure
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine structure
CAS No.
61337-89-1
Chemical Name:
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine
Synonyms
1-(3-HYDROXYMETHYL PYRIDIN-2-YL)-2-PHENYL-4-METHYL PIPERAZINE;Mirtazapine EP IMpurity B;1-(3-HYDROXYMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE;Misoprolol;Mirtazapine IMpurity B;1-(3-Hydroxymethylpyridin-2-Yl;Mirtazapine Penutimate Impurity-B;[2-[(2RS)-4-Methyl-2-phenylpiperazi;Mirtazapine Impurity 2(Mirtazapine EP Impurity B);2-(4-METHYL-2-PHENYL-1-PIPERAZINYL)-3-PYRIDINEMETHANOL
CBNumber:
CB1263044
Molecular Formula:
C17H21N3O
Molecular Weight:
283.37
MDL Number:
MFCD08063948
MOL File:
61337-89-1.mol
MSDS File:
SDS
Last updated:2026-05-27 23:20:58
Product description Number Pack Size Price
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol FM25652 5g $295
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol FM25652 10g $413
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol 198635 5.00mg $90
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol 198635 10.00mg $122
2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol 198635 25.00mg $185
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1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine Properties

Melting point 113-115°C
Boiling point 478.8±45.0 °C(Predicted)
Density 1.161±0.06 g/cm3(Predicted)
vapor pressure 0-0Pa at 20-25℃
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Sparingly), Methanol (Slightly)
form Solid
pka 13.59±0.10(Predicted)
color White to Off-White
InChI InChI=1S/C17H21N3O/c1-19-10-11-20(17-15(13-21)8-5-9-18-17)16(12-19)14-6-3-2-4-7-14/h2-9,16,21H,10-13H2,1H3
InChIKey PYZPABZGIRHQTA-UHFFFAOYSA-N
SMILES C1(N2CCN(C)CC2C2=CC=CC=C2)=NC=CC=C1CO
LogP 1.3 at 20℃
Surface tension 59.72N/m at 1g/L and 20℃
CAS DataBase Reference 61337-89-1(CAS DataBase Reference)
FDA UNII XRO2GE880O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
REACH Registrations Active

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FM25652 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol 61337-89-1 5g $295 2026-06-04 Buy
Biosynth FM25652 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol 61337-89-1 10g $413 2026-06-04 Buy
Matrix Scientific 198635 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol 61337-89-1 5.00mg $90 2026-05-18 Buy
Matrix Scientific 198635 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol 61337-89-1 10.00mg $122 2026-05-18 Buy
Matrix Scientific 198635 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol 61337-89-1 25.00mg $185 2026-05-18 Buy
Product number Packaging Price Buy
FM25652 5g $295 Buy
FM25652 10g $413 Buy
198635 5.00mg $90 Buy
198635 10.00mg $122 Buy
198635 25.00mg $185 Buy

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

An impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.

Uses

2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol is an impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.

Synthesis

1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine

61338-13-4

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine

61337-89-1

General procedure for the synthesis of 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol from 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinecarboxylic acid: 1618 mL (1618 mmol) of a 1 mol/L lithium aluminum hydride solution in tetrahydrofuran was added to a 2 L four-necked flask equipped with stirring blades and a thermometer. Subsequently, 120 g (404 mmol) of 2-(4-methyl-2-phenyl-1-piperazine)-3-pyridinecarboxylic acid was dissolved in 1800 mL of tetrahydrofuran, the reaction temperature was maintained at about 25 °C and the solution was added slowly dropwise to the reaction flask over a period of 30 min. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 25°C for 3 hours. Upon completion of the reaction, 70 mL of water was slowly added while the reaction solution was cooled with a water bath and the mixture was stirred. After that, the organic and aqueous layers were separated, and the organic layer was washed sequentially with 70 mL of 15 wt% aqueous sodium hydroxide solution and 200 mL of water. The organic layer was concentrated under reduced pressure to give a crude product of 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol. To the crude product was added 840 mL of isopropyl acetate, heated to 60°C to dissolve it completely, and then 840 mL of heptane was added slowly and dropwise at an internal temperature of not less than 50°C. The resulting solution was cooled to 5°C and the slurry was aged at that temperature for 2 hours. Subsequently, the solid was collected by vacuum filtration and the crystals obtained by filtration were washed with a mixture of 60 mL of isopropyl acetate and 60 mL of heptane. Finally, the white crystals were dried under reduced pressure at 40 °C for 5 h to obtain 102 g (363 mmol, yield: 89%) of 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridine methanol with a purity of 99.53% and a water content of 320 ppm.

References

[1] Patent: US2002/35255, 2002, A1
[2] Organic Preparations and Procedures International, 2007, vol. 39, # 4, p. 399 - 402
[3] Patent: JP2017/39659, 2017, A. Location in patent: Paragraph 0048-0049
[4] Patent: JP2017/88565, 2017, A. Location in patent: Paragraph 0060; 0061
[5] Patent: JP2017/88564, 2017, A. Location in patent: Paragraph 0056; 0057

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine Preparation Products And Raw materials

Raw materials

1-(3-Cyanopyridyl-2)-2-Phenyl-4-Methylpyperazine 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

Mirtazapine

1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine Suppliers

Global( 197)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 923 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88298848 info@edengenechem.com China 2165 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1319 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Changzhou Ditong Chemical Co.,Ltd 		58
Standardpharm Co. Ltd. 		58
Alchem Pharmtech,Inc. 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58

View Lastest Price from 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine pictures 2025-03-04 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine
61337-89-1
 1kg 99%min 20 tons Hangzhou Verychem Science And Technology Co.Ltd
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine pictures 2021-08-12 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine
61337-89-1
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine pictures 2019-07-06 1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine
61337-89-1
 $1.00 1kg 98%min Career Henan Chemical Co

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[2-(4-METHYL-2-PHENYLPIPERAZIN-1-YL)PYRIDIN-3-YL]METHANOL 2-(4-METHYL-2-PHENYL-1-PIPERAZINYL)-3-PYRIDINEMETHANOL 1-(3-HYDROXYMETHYL PYRIDIN-2-YL)-4-METHYL-2-PHENYL PIPERAZINE 1-(3-HYDROXYMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE 1-(3-HYDROXIDMETHYLPYRIDINE)-2-PHENYL-4-METHYL-PIPERAZINE 1-(3-Hydroxymethylpyridyl-2)-2-Phenyl-4-Methylpyperazine 1-(3-Hydroxymethylpyridin-2-Yl 2-(4-methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol (intermediate of mirtazapine) 2-[(2-chloro-phenyl)-acetyl benzoic acid (intermediate of azelastine hcl) 2-[(2-phenyl-4-methyl)-piperazine-1-yl]pyridine-3-methanol (intermediate of mirtazapine) 1--3--2-(4-METHYL-2-PHENYL-1-PIPERAZINE)-3-PYRIDINE METHANOL (PREPARATION FOR MIRTAZAPINE) D-(+)-METHYL-ALPHA-(2-THIENYLETHAMINO)(2-CHLOROPHENYL)ACETATEHCL 2-[(2-PHENYL-4-METHYL)-PIPERAZINE-1-YL]PYRIDINE-3-METHANO 1-(3-HydroxyMethyl-2-pyridyl)-4-Methyl-2-phenylpiperazine 2-(4-Methyl-2-phenylpiperazin-1-yl)pyridine-3-Methanol Mirtazapine IMpurity B 1-(3-hydroxy Methyl pyridine-2-yl)-4-Methyl-2-phenyl piperazine 3-Pyridinemethanol, 2-(4-methyl-2-phenyl-1-piperazinyl)- 1-(3-HYDROXY METHYL PYRIDYL-2-)2 PHENYL 4 METHYL PIPERAZINE [MRT-6] Mirtazapine Impurity 2(Mirtazapine EP Impurity B) Mirtazapine EP Impurity B/[2-[(2RS)-4-Methyl-2-phenylpiperazin-1-yl]pyridin-3-yl]methanol [2-[(2RS)-4-Methyl-2-phenylpiperazi 1-(3-HydroxyMethyl pyridyl-2)-2-phenyl-4-methyl Piperazine (N-1 Intermdediate) (3-Hydroxymethylpyridyl-2)-2-phenyl-4-methylpyperazine Misoprolol Mirtazapine Penutimate Impurity-B 1-(3-Hydroxymethyl-2-pyridinyl)-2-phenyl-4-methylpiperazine 1-(3-HYDROXYMETHYL PYRIDIN-2-YL)-2-PHENYL-4-METHYL PIPERAZINE Mirtazapine EP IMpurity B 61337-89-1 C17H21N3O Intermediate Mirtazapine l(intermediate of mirtazapine) Aromatics Heterocycles Miscellaneous Reagents Alkohols Organic acids Piperazine derivates (intermediate of mirtazapine) (intermediate of azelastine hcl)