PF-543 (Citrate)
- CAS No.
- 1415562-83-2
- Chemical Name:
- PF-543 (Citrate)
- Synonyms
- PF-543 (Citrate);PWXXWUWKNPXSGW-VQIWEWKSSA-N;PF543 CITRATE; PF 543 CITRATE;Sphingosine Kinase 1 Inhibitor II Citrate;(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol 2-hydroxy-1,2,3-propanetricarboxylate;(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- CBNumber:
- CB12645149
- Molecular Formula:
- C33H39NO11S
- Molecular Weight:
- 657.73
- MDL Number:
- MFCD23098795
- MOL File:
- 1415562-83-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| PF-543(Citrate) 98.10% | CS-1072 | 5mg | $95 |
| PF543citrate 98% | Axon2350 | 5mg | $108.9 |
| PF-543Citrate | A3718 | 5mg | $110 |
| PF-543(Citrate) 98.10% | CS-1072 | 10mg | $140 |
| PF-543Citrate | A3718 | 10mg | $195 |
PF-543 (Citrate) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1072 | PF-543(Citrate) 98.10% | 1415562-83-2 | 5mg | $95 | 2021-12-16 | Buy |
| Axon Medchem | Axon2350 | PF543citrate 98% | 1415562-83-2 | 5mg | $108.9 | 2021-12-16 | Buy |
| ApexBio Technology | A3718 | PF-543Citrate | 1415562-83-2 | 5mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-1072 | PF-543(Citrate) 98.10% | 1415562-83-2 | 10mg | $140 | 2021-12-16 | Buy |
| ApexBio Technology | A3718 | PF-543Citrate | 1415562-83-2 | 10mg | $195 | 2021-12-16 | Buy |
PF-543 (Citrate) Chemical Properties,Uses,Production
Uses
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy[1][2][3].
in vivo
PF-543 (1 mg/kg; intraperitoneal injection; every second day; for 21 days; female C57BL/6 J mice) treatment has no effect on vascular remodelling but reduces right ventricular hypertrophy. The protection involves a reduction in the expression of p53 and an increase in the expression of anti-oxidant nuclear factor Nrf-2[2].
Mice are initially dosed (ip) with 10 mg/kg or 30 mg/kg of PF-543 for 24 h and the T1/2 is 1.2 h in blood samples. Administration of 10 mg/kg PF-543 for 24 h to mice induces a decrease in SK1 expression in pulmonary vessels[2].
| Animal Model: | Female C57BL/6 J mice (7-12 week-old) with hypoxic-induced pulmonary arterial hypertension[2] |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection; every second day; for 21 days |
| Result: | Reduced right ventricular hypertrophy. The protection involves a reduction in the expression of p53 (that promotes cardiomyocyte death) and an increase in the expression of anti-oxidant nuclear factor Nrf-2. |
IC 50
SphK1
References
[1] Schnute ME, et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88. DOI:10.1042/BJ20111929
[2] MacRitchie N, et al. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cell Signal. 2016 Aug;28(8):946-55. DOI:10.1016/j.cellsig.2016.03.014
[3] Hamada M, et al. Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells. Cell Death Discov. 2017 Aug 14;3:17047. DOI:10.1038/cddiscovery.2017.47
PF-543 (Citrate) Preparation Products And Raw materials
Raw materials
Preparation Products
PF-543 (Citrate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6003 | 61 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3866 | 58 |
View Lastest Price from PF-543 (Citrate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | PF-543 Citrate
1415562-83-2
|
US $0.00 / removed | 99.33% | 10g | TargetMol Chemicals Inc. |
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- PF-543 Citrate
1415562-83-2
- US $0.00 / removed
- 99.33%
- TargetMol Chemicals Inc.
