Dirlotapide
- CAS No.
- 481658-94-0
- Chemical Name:
- Dirlotapide
- Synonyms
- Slentrol;CP742033;Dirlotapide;(S)-N-[2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[4'-(trifluoromethyl)-2-biphenylylcarboxamido]indole-2-carboxamide;1H-Indole-2-carboxamide, 1-methyl-N-[(1S)-2-[methyl(phenylmethyl)amino]-2-oxo-1-phenylethyl]-5-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-
- CBNumber:
- CB12648771
- Molecular Formula:
- C40H33F3N4O3
- Molecular Weight:
- 674.71
- MDL Number:
- MFCD27976718
- MOL File:
- 481658-94-0.mol
- MSDS File:
- SDS
| Boiling point | 821.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 12.40±0.46(Predicted) |
| color | White to off-white |
| FDA UNII | 578H0RMP25 |
Dirlotapide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | GUA65894 | Dirlotapide | 481658-94-0 | 1mg | $3035.87 | 2026-06-04 | Buy |
| ChemScene | CS-6779 | Dirlotapide 99.86% | 481658-94-0 | 1mg | $758 | 2026-06-04 | Buy |
| aablocks | AA00DJV0 | Dirlotapide | 481658-94-0 | 1mg | $620 | 2026-05-28 | Buy |
| aablocks | AA00DJV0 | Dirlotapide | 481658-94-0 | 5mg | $1244 | 2026-05-28 | Buy |
| aablocks | AA00DJV0 | Dirlotapide | 481658-94-0 | 10mg | $1604 | 2026-05-28 | Buy |
Dirlotapide Chemical Properties, Uses, Production
Uses
Treatment of obesity in companion animals (dogs) (gut microsomal triglyceride transport protein (gMTP) inhibitor) .
Veterinary Drugs and Treatments
Dirlotapide oral solution is indicated for the management of obesity in dogs.
in vivo
Dogs receiving 0.3 mg dirlotapide/kg once daily have a small but significant (P=0.018) decrease (6.16 ± 2.22%, mean ± SD) in crude fat digestibility compared with the placebo-treated food-restricted dogs, but no difference in crude protein, dry matter, or energy digestibility is observed. Dirlotapide effectively reduces appetite and energy intake without affecting nutrient digestibility, except for a minimal decrease in fat digestibility[1]. Dirlotapide (0.5 mg/kg) results in a high rate of weight loss (3.3% weekly) and anorexia, emesis, and loose stools for some dogs. Dirlotapide produces weight loss by both reducing appetite (about 90% of the weight loss activity) and by increasing fecal fat excretion (about 10% of the weight loss activity)[2].
Dirlotapide Preparation Products And Raw materials
Raw materials
Preparation Products
Dirlotapide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2970 | 58 |
| Wuhan FengyaoTonghui Chemical Products Co., Ltd. | 027-87466105 15377573527 | 2678564200@qq.com | China | 17968 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15030 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Lotusland Life Sciences | +8615821988213 | info@longyupharma.com | China | 2411 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
