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Birinapant

Birinapant structure

CAS No.: 1260251-31-7

Chemical Name:: Birinapant

Synonyms: CS-801;TL 32711;Birinapan;Birinapant;SMAC mimetic;TL-32711 ≥98%;Birinapant, >=98%;Birinapant (TL32711);TL 32711. Birinapant;Birinapant USP/EP/BP

CBNumber:: CB12658183

Molecular Formula:: C42H56F2N8O6

Molecular Weight:: 806.94

MDL Number:: MFCD25976869

MOL File:: 1260251-31-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
Birinapant ≥95%	19699	1mg	$63
Birinapant ≥95%	19699	5mg	$213
Birinapant ≥95%	19699	10mg	$363
Birinapant ≥95%	19699	25mg	$678
Birinapant	442740	2.5mg	$382
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Birinapant Properties

Melting point	>245oC (dec.)
Boiling point	1090.5±65.0 °C(Predicted)
Density	1.320±0.06(20.0000℃)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	13.99±0.46(Predicted)
form	Solid
color	White to Off-White
InChIKey	PKWRMUKBEYJEIX-AUTGSTJINA-N
FDA UNII	6O4Z07B57R
NCI Drug Dictionary	birinapant

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338
HS Code	29339900

Birinapant price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	19699	Birinapant ≥95%	1260251-31-7	1mg	$63	2026-04-30	Buy
Cayman Chemical	19699	Birinapant ≥95%	1260251-31-7	5mg	$213	2026-04-30	Buy
Cayman Chemical	19699	Birinapant ≥95%	1260251-31-7	10mg	$363	2026-04-30	Buy
Cayman Chemical	19699	Birinapant ≥95%	1260251-31-7	25mg	$678	2026-04-30	Buy
Usbiological	442740	Birinapant	1260251-31-7	2.5mg	$382	2026-06-03	Buy

Product number	Packaging	Price	Buy
19699	1mg	$63	Buy
19699	5mg	$213	Buy
19699	10mg	$363	Buy
19699	25mg	$678	Buy
442740	2.5mg	$382	Buy

Birinapant Chemical Properties,Uses,Production

Description

Birinapant is a bivalent mimetic of the Diablo homolog known as second mitochondria-derived activator of caspase (Smac). It is an antagonist of cellular inhibitor of apoptosis 1 (cIAP1, or BIRC2), cIAP2 (BIRC3), and XIAP (BIRC4), binding each at nanomolar concentrations. Birinapant causes rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation in breast cancer cells. It shows in vivo antitumor activity, inducing apoptosis in several types of cancer xenografts in mice.

Uses

Birinapant is a bivalent SMAC mimetic compound antagonist of TRAF2 associated cIAP1 and cIAP2.

Definition

ChEBI: Birinapant is a dipeptide.

Enzyme inhibitor

This rotationally symmetric SMAC mimetic antagonist and anticancer agent (FW = 806.94 g/mol; CAS 1260251-31-7) targets cellular Inhibitor of Apoptosis Protein (or cIAP1; Kd of <1 nM), arguably the most potent mammalian caspase inhibitor, showing single-agent efficacy due to its panIAP antagonism and causing rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation. When administered in combination with TNF-α, Birinapant is effective against a melanoma cell line with acquired resistance to BRAF inhibitors

target

XIAP

References

[1] JENNIFER L ALLENSWORTH. Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.[J]. Breast Cancer Research and Treatment, 2013, 137 2: 359-371. DOI: 10.1007/s10549-012-2352-6
[2] CLEMENS KREPLER. The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells.[J]. Clinical Cancer Research, 2013, 19 7: 1784-1794. DOI: 10.1158/1078-0432.ccr-12-2518
[3] QUANG-Dé NGUYEN. Temporal and spatial evolution of therapy-induced tumor apoptosis detected by caspase-3-selective molecular imaging.[J]. Clinical Cancer Research, 2013, 19 14: 3914-3924. DOI: 10.1158/1078-0432.ccr-12-3814

Birinapant Preparation Products And Raw materials

Raw materials

Preparation Products

Birinapant Suppliers

Global( 166)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30203	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6290	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29096	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15058	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9539	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10378	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from Birinapant manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	Birinapant 1260251-31-7	$41.00-117.00		99.78%	10g	TargetMol Chemicals Inc.
	2021-07-02	Birinapant 1260251-31-7	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Birinapant
1260251-31-7
$41.00-117.00
99.78%
TargetMol Chemicals Inc.

Birinapant
1260251-31-7
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Birinapant Spectrum

Birinapant(1260251-31-7)¹HNMR

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Birinapant Birinapant (TL32711) TL 32711 Birinapant(TL32711)/TL-32711/TL32711/TL-32711 (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-, (2S,2'S)- (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide Birinapant TL 32711 Birinapant (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-propanamide Birinapant, >=98% (2S,2'S)-N,N'-[(6,6'-Difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]b Birinapant, Free Base Birinapan TL-32711 ≥98% (2S,2'S)-N,N'-[(6,6'-DIFLUORO[2,2'-BI-1H-INDOLE]-3,3'-DIYL)BIS[METHYLENE[(2R,4S)-4-HYDROXY-2,1-PYRRO TL 32711. Birinapant TL-32711; TL32711; TL 32711. BIRINAPANT CS-801 Birinapant USP/EP/BP (2S,2'S)-N,N'-((2S,2'S)-((3S,3'S,5R,5'R)-5,5'-((6,6'-Difluoro-1H,1'H-[2,2'-biindole]-3,3'-diyl)bis(methylene))bis(3-hydroxypyrrolidine-5,1-diyl))bis(1-oxobutane-2,1-diyl))bis(2-(methylamino)propanamide) SMAC mimetic Birinapant, 10 mM in DMSO (2S)-N-((2R)-1-((4S)-2-((6,6'-difluoro-3'-(((2S,4S)-4-hydroxy-1-(2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidin-2-yl)methyl)-1H,1'H-[2,2'-biindol]-3-yl)methyl)-4-hydroxypyrrolidin-1-yl)-1-oxobutan-2-yl)-2-(methylamino)propanamide 1260251-31-7 C42H56F2N8O6 Inhibitors Inhibitor