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Flumatinib mesylate

Flumatinib mesylate structure

CAS No.: 895519-91-2

Chemical Name:: Flumatinib mesylate

Synonyms: CS-1023;HHGV678 mesylate;FluMatinib Mesylate;Flumatinib mesylate (HHGV-678);Flumatinib mesylate, 10 mM in DMSO;N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl);N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide methanesulfonate;methanesulfonic acid,4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide;HHGV-678,PDGFRβ,HHGV678,c-Abl,Bcr-Abl,Platelet-derived growth factor receptor,PDGFR,HHGV 678,SCFR,Flumatinib mesylate,c-Kit,Flumatinib,CD117,Inhibitor,inhibit;BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)

CBNumber:: CB12667200

Molecular Formula:: C30H33F3N8O4S

Molecular Weight:: 658.6944296

MDL Number:: MFCD28053502

MOL File:: 895519-91-2.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:38

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Flumatinib mesylate Properties

storage temp.	Store at -20°C
solubility	H2O : 50 mg/mL (75.91 mM; Need ultrasonic)DMSO : 50 mg/mL (75.91 mM; Need ultrasonic)
form	Powder
color	Light brown to yellow
FDA UNII	95Y8L63NBC
NCI Drug Dictionary	flumatinib mesylate

Flumatinib mesylate price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ApexBio Technology	A8691	Flumatinibmesylate	895519-91-2	500mg	$91	2021-12-16	Buy
ChemScene	CS-1826	Flumatinib(mesylate) 99.97%	895519-91-2	500mg	$120	2021-12-16	Buy
ApexBio Technology	A8691	Flumatinibmesylate	895519-91-2	1g	$155	2021-12-16	Buy
Crysdot	CD31000381	Flumatinibmesylate 98+%	895519-91-2	250mg	$47	2021-12-16	Buy

Product number	Packaging	Price	Buy
A8691	500mg	$91	Buy
CS-1826	500mg	$120	Buy
A8691	1g	$155	Buy
CD31000381	250mg	$47	Buy

Flumatinib mesylate Chemical Properties,Uses,Production

Uses

Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model[1][2].

in vivo

Flumatinib mesylate (HH-GV-678) (18-75 mg/kg; p.o.; Twice daily, for 14 days.) inhibits tumor growth in nude mice^[1].

Animal Model:	Nude mice (subcutaneously injecting K562 cells)^[1]
Dosage:	18.75, 37.5, 75 mg/kg
Administration:	Oral administration; Twice daily, for 14 days.
Result:	Inhibited the growth of K562 xenografts in a dose-dependent manner and induced regression in all tumors at a daily dose of 75 mg/kg for nine days.

IC 50

PDGFRβ: 307.6 nM (IC₅₀); c-Abl: 1.2 nM (IC₅₀)

References

[1] Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance. Leukemia. 2010 Oct;24(10):1807-9. DOI:10.1038/leu.2010.169
[2] Zhao J, et al. Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2013 Nov 10. DOI:10.1111/cas.12320

Flumatinib mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

Flumatinib mesylate Suppliers

Global( 61)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29807	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38664	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
Shanghai Hanhong Scientific Co., Ltd.	+undefined17612118332	Lucky@hanhonggroup.com	China	6035	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7552	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2782	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Hanhong Scientific Co., Ltd.	58
Amadis Chemical Company Limited	58
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
AdooQ BioScience, LLC	58

How to synthesize Flumatinib mesylate?
Flumatinib mesylate, also known as HHGV-678, is a selective inhibitor of the tyrosine kinase BCR-ABL1. The drug was discovered....
Jan 19，2024

View Lastest Price from Flumatinib mesylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-05	BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI) 895519-91-2	US $1.00 / KG	1KG	95--99%	1ton	Career Henan Chemical Co

BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)
895519-91-2
US $1.00 / KG
95--99%
Career Henan Chemical Co

895519-91-2(Flumatinib mesylate)Related Search:

Lenalidomide

BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI) FluMatinib Mesylate BenzaMide, 4-[(4-Methyl-1-piperazinyl)Methyl]-N-[6-Methyl-5-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-3-pyridinyl]-3-(trifluoroMethyl)-, MonoMethanesulfonate (9CI)/FluMatinib Mesylate N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl) methanesulfonic acid,4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]pyridin-3-yl]-3-(trifluoromethyl)benzamide CS-1023 HHGV678 mesylate Flumatinib mesylate (HHGV-678) N-(6-Methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)pyridin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide methanesulfonate HHGV-678,PDGFRβ,HHGV678,c-Abl,Bcr-Abl,Platelet-derived growth factor receptor,PDGFR,HHGV 678,SCFR,Flumatinib mesylate,c-Kit,Flumatinib,CD117,Inhibitor,inhibit Flumatinib mesylate, 10 mM in DMSO 895519-91-2 C29H29F3N8OCH4O3S C30H33F3N8O4S