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Gefitinib-d6

Gefitinib-d6 Structure
Gefitinib-d6 structure
CAS No.
1228664-49-0
Chemical Name:
Gefitinib-d6
Synonyms
Gefitinib-d6;D6-Gefitinib;[2H6]-Gefitinib;Hexadeuterated gefitinib;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
CBNumber:
CB12674404
Molecular Formula:
C22H24ClFN4O3
Molecular Weight:
446.91
MDL Number:
MFCD21363632
MOL File:
1228664-49-0.mol
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
Product description Number Pack Size Price
Gefitinib-d6 ≥99% deuterated forms (d1-d6) 22364 500μg $130
Gefitinib-d6 ≥99% deuterated forms (d1-d6) 22364 1mg $243
Gefitinib-d6 G304008 10mg $1540
Gefitinib-d6 G304008 25mg $3520
Gefitinib-d6 3663DG 1mg $370
Request For Quotation

Gefitinib-d6 Properties

storage temp. Store at -20°C
solubility DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
form A solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501
NFPA 704
0
3 0

Gefitinib-d6 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22364 Gefitinib-d6 ≥99% deuterated forms (d1-d6) 1228664-49-0 500μg $130 2024-03-01 Buy
Cayman Chemical 22364 Gefitinib-d6 ≥99% deuterated forms (d1-d6) 1228664-49-0 1mg $243 2024-03-01 Buy
TRC G304008 Gefitinib-d6 1228664-49-0 10mg $1540 2021-12-16 Buy
TRC G304008 Gefitinib-d6 1228664-49-0 25mg $3520 2021-12-16 Buy
AK Scientific 3663DG Gefitinib-d6 1228664-49-0 1mg $370 2021-12-16 Buy
Product number Packaging Price Buy
22364 500μg $130 Buy
22364 1mg $243 Buy
G304008 10mg $1540 Buy
G304008 25mg $3520 Buy
3663DG 1mg $370 Buy

Gefitinib-d6 Chemical Properties,Uses,Production

Description

Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).

Uses

Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.

References

[1] JOHN MENDELSOHN  Jose B. The EGF receptor family as targets for cancer therapy[J]. Oncogene, 2000, 19 56: 6550-6565. DOI: 10.1038/sj.onc.1204082
[2] F CIARDIELLO. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.[J]. Clinical Cancer Research, 2000, 6 5: 2053-2063.

Gefitinib-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

Gefitinib-d6 Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19957 58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd. 		+undefined18603013401 jack.lin@sincopharmachem.com China 9996 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57422 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Cato Research Chemicals Inc. +86-020-81960175-877 4000-868-328 tianwen.zhan@cato-chem.com United States 10404 58
Shanghai YuZn Pharm. Technology Co.,Ltd. 15921286451; 15921286451 2010681527@qq.com China 4918 58
CHINA ISOTOPE CO., LIMITED 02151600108 13062666369 info@isotopechem.com China 4724 58
Shanghai Beiwanta Biotechnology Co., Ltd. 021-67187366 19901745723 info@bwtlab.com China 9778 58
Supplier Advantage
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd. 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Cato Research Chemicals Inc. 58
Shanghai YuZn Pharm. Technology Co.,Ltd. 58
CHINA ISOTOPE CO., LIMITED 58
Shanghai Beiwanta Biotechnology Co., Ltd. 58

View Lastest Price from Gefitinib-d6 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Gefitinib-D6 pictures 2026-04-20 Gefitinib-D6
1228664-49-0
 US $0.00-0.00 / mg 10g TargetMol Chemicals Inc.
  • Gefitinib-D6 pictures
  • Gefitinib-D6
    1228664-49-0
  • US $0.00-0.00 / mg
  • TargetMol Chemicals Inc.

1228664-49-0(Gefitinib-d6)Related Search:

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Gefitinib-d6 Hexadeuterated gefitinib [2H6]-Gefitinib N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine D6-Gefitinib 1228664-49-0