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ACT-132577

ACT-132577 Structure
ACT-132577 structure
CAS No.
1103522-45-7
Chemical Name:
ACT-132577
Synonyms
ACT-132577;Aprocitentan;Depropylmethacetin;Despropyl Macitentan;Macitentan ACT-132577;N-Despropyl Macitentan;Macitentan Impurity 07;Macitentan ACT-132577-D4;Aprocitentan, 10 mM in DMSO;Macitentan N-Despropyl Impurity
CBNumber:
CB12685914
Molecular Formula:
C16H14Br2N6O4S
Molecular Weight:
546.19
MDL Number:
MFCD28155267
MOL File:
1103522-45-7.mol
MSDS File:
SDS
Last updated:2025-04-28 21:36:36
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ACT-132577 Properties

Melting point 139-141°C
Boiling point 705.0±70.0 °C(Predicted)
Density 1.841±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form Solid
pka 13.56±0.60(Predicted)
color White to Off-White
FDA UNII MZI81HV01P

ACT-132577 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D297305 N-DespropylMacitentan 1103522-45-7 10mg $580 2021-12-16 Buy
TRC D297305 N-DespropylMacitentan 1103522-45-7 5mg $305 2021-12-16 Buy
TRC D297305 N-DespropylMacitentan 1103522-45-7 50mg $1635 2021-12-16 Buy
ChemScene CS-2687 Aprocitentan 98.13% 1103522-45-7 100mg $2520 2021-12-16 Buy
ChemScene CS-2687 Aprocitentan 98.13% 1103522-45-7 5mg $420 2021-12-16 Buy
Product number Packaging Price Buy
D297305 10mg $580 Buy
D297305 5mg $305 Buy
D297305 50mg $1635 Buy
CS-2687 100mg $2520 Buy
CS-2687 5mg $420 Buy

ACT-132577 Chemical Properties,Uses,Production

Uses

N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)

Definition

ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.

in vivo

Aprocitentan (ACT-132577) has a volume of distribution greater than the plasma volume and a longer half-life than its parent compound in the rat[1]. In rat plasma, the mean recovery of Aprocitentan (ACT-132577) ranges from 82.6% to 90.6%, matrix effect of Aprocitentan (ACT-132577) in rat plasma ranges from 101.4% to 115.2%[2].

IC 50

ETA: 3.4 nM (IC50); ETA: 6.7 (pA2); ETB: 987 nM (IC50); ETB: 5.5 (pA2)

ACT-132577 Preparation Products And Raw materials

Raw materials

Preparation Products

ACT-132577 Suppliers

Global( 169)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Jianfeng Chemical Co., Ltd 		+86-0531-88110457 +86-15562555968 info@pharmachemm.com China 333 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
ENBRIDGE PHARMTECH CO., LTD. 		+8613812269233 tinayang@enbridgepharm.com China 322 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
Supplier Advantage
Jinan Jianfeng Chemical Co., Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Jinan Carbotang Biotech Co.,Ltd. 		58
Shochem(Shanghai) Co.,Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
ENBRIDGE PHARMTECH CO., LTD. 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
sgtlifesciences pvt ltd 		58

View Lastest Price from ACT-132577 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Aprocitentan pictures 2025-05-14 Aprocitentan
1103522-45-7
 US $0.00-0.00 / g 1g 99% 1000 Jinan Jianfeng Chemical Co., Ltd
Aprocitentan pictures 2025-05-13 Aprocitentan
1103522-45-7
 US $0.00-0.00 / g 1g 98 1000 Wuhan Circle Star Chem-medical Technology Co.,Ltd
Aprocitentan pictures 2025-04-27 Aprocitentan
1103522-45-7
 US $53.00-178.00 / mg 99.17% 10g TargetMol Chemicals Inc.
  • Aprocitentan pictures
  • Aprocitentan
    1103522-45-7
  • US $0.00-0.00 / g
  • 99%
  • Jinan Jianfeng Chemical Co., Ltd
  • Aprocitentan pictures
  • Aprocitentan
    1103522-45-7
  • US $0.00-0.00 / g
  • 98
  • Wuhan Circle Star Chem-medical Technology Co.,Ltd
  • Aprocitentan pictures
  • Aprocitentan
    1103522-45-7
  • US $53.00-178.00 / mg
  • 99.17%
  • TargetMol Chemicals Inc.
N-Despropyl Macitentan Aprocitentan 5-(4-BROMOPHENYL)-4-[2-(5-BROMOPYRIMIDIN-2-YL)OXYETHOXY]-6-(SULFAMOYLAMINO)PYRIMIDINE ACT-132577 N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN Despropyl Macitentan Macitentan N-Despropyl Impurity Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]- N-[5-(4-bromophenyl)-6-[2-(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl Macitentan ACT-132577 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(sulfamoyl)pyrimidin-4-amine Macitentan ACT-132577-D4 Macitentan Impurity 07 N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]aminosulfonamide 5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]-ethoxy]-4-pyrimidinyl]sulfamide Despropyl Macitentan (COLD SHIPMENT REQUIRED) N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfamide N-(5-(4-Bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)sulfamide , Aprocitentan Aprocitentan, 10 mM in DMSO N - [5- (4-bromophenyl) -6- [2- [(5-bromo-2-pyrimidinyl) oxy] ethoxy] -4-pyrimidinyl] aminosulfonamide Depropylmethacetin 1103522-45-7 110-65-7 C16H14Br2N6O4S APIS API