6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine
- CAS No.
- 1123194-98-8
- Chemical Name:
- 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine
- Synonyms
- EOS-60781;6-Bromo-2-methoxy-3-(4-methylimidazol-1-yl)pyridine;6-Bromo-2-methoxy-3-(4-methyl-1-imidazolyl)pyridine;6-bromo-2-methoxy-3-(3-methyl-1H-pyrrol-1-yl)pyridine;6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine;Pyridine, 6-bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)-
- CBNumber:
- CB12693746
- Molecular Formula:
- C10H10BrN3O
- Molecular Weight:
- 268.11
- MDL Number:
- MFCD19690830
- MOL File:
- 1123194-98-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P260-P280-P312 |
| HS Code | 2933399990 |
6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 102444 | 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine | 1123194-98-8 | 1.00g | $79 | 2026-05-18 | Buy |
| Matrix Scientific | 102444 | 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine | 1123194-98-8 | 5.00g | $245 | 2026-05-18 | Buy |
| Matrix Scientific | 102444 | 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine | 1123194-98-8 | 25.00g | $937 | 2026-05-18 | Buy |
| Synthonix | B52345 | 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine 95+% | 1123194-98-8 | 100mg | $39 | 2026-05-06 | Buy |
| Synthonix | B52345 | 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine 95+% | 1123194-98-8 | 250mg | $45 | 2026-05-06 | Buy |
6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine Chemical Properties, Uses, Production
Synthesis
1123194-97-7
1123194-98-8
Ammonium acetate (43 g, 553 mmol) was dissolved in acetic acid (208 mL) under argon protection and stirred for 30 minutes at room temperature. Subsequently, N-(6-bromo-2-methoxypyridin-3-yl)-N-(2-oxopropyl)formamide (32 g, 111 mmol) was added to the mixture and kept at room temperature. The reaction system was warmed up to 130 °C with continuous stirring for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction mixture was diluted with ice water (200 mL) and the pH was adjusted to 7 with 50% sodium hydroxide solution (200 mL), at which point a solid precipitated. The solid was collected by filtration, washed with ether (100 mL) and dried under vacuum to afford the target product 6-bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine (17.5 g, 60% yield) as an off-white solid. The product was characterized by 1H NMR (CDCl3, 400 MHz) and LCMS: 1H NMR δ 7.72 (s, 1H), 7.39 (d, 1H), 7.16 (d, 1H), 6.91 (s, 1H), 4.03 (s, 3H), 2.29 (s, 3H); LCMS purity 99.3%, m/z 267.9 ([M+H]+) Chromatographic conditions: Ascentis Express C-18 column (50 x 3.0 mm, 2.7 μm), retention time 1.54 min, mobile phase 0.025% TFA aqueous solution + 5% acetonitrile: acetonitrile + 5% 0.025% TFA aqueous solution, gradient elution (0.0/5, 0.5/5, 3/100, 5/100), flow rate 1.2 mL/min; TLC unfolding agent was 40% ethyl acetate/hexane (Rf 0.2).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 21, p. 9089 - 9106,18
[2] Patent: WO2010/56722, 2010, A1. Location in patent: Page/Page column 369
[3] Patent: WO2016/201168, 2016, A1. Location in patent: Paragraph 0870
[4] Patent: WO2017/31325, 2017, A1. Location in patent: Paragraph 0319; 0424
[5] Patent: US2017/44182, 2017, A1. Location in patent: Paragraph 0976
6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
| ShangHai Movin Pharmaceutical Co., Ltd. | 13681854265 | info@moenpharm.com | China | 488 | 55 |
| Tcichem, Inc. | 13918644899 | 81587635@qq.com | China | 1994 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6347 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
