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Sparsentan

Sparsentan structure

CAS No.: 254740-64-2

Chemical Name:: Sparsentan

Synonyms: Sparsentan;RE-021;2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide;RE 201;DARA-a;PS433540;Sparentan;Spasentan;BMS-346567;Spashentan

CBNumber:: CB12707221

Molecular Formula:: C32H40N4O5S

Molecular Weight:: 592.75

MDL Number:: MFCD16628036

MOL File:: 254740-64-2.mol

Last updated:2025-10-13 18:39:35

Product description	Number	Pack Size	Price
Sparsentan ≥98% (HPLC)	SML2808	5MG	$83.31
Sparsentan ≥98% (HPLC)	SML2808	25MG	$362
RE201	R129300	1mg	$165
RE201	R129300	10mg	$1320
RE201	72248	10mg	$2200

Request For Quotation

Sparsentan Properties

Melting point	148 °C(Solv: isopropanol (67-63-0); water (7732-18-5))
Boiling point	744.4±70.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: soluble
form	A crystalline solid
pka	7.06±0.50(Predicted)
color	White to off-white
InChIKey	WRFHGDPIDHPWIQ-UHFFFAOYSA-N
SMILES	C1(C2=CC=C(CN3C(=O)C4(CCCC4)N=C3CCCC)C=C2COCC)=CC=CC=C1S(NC1C(C)=C(C)ON=1)(=O)=O
FDA UNII	9242RO5URM
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Sparsentan price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML2808	Sparsentan ≥98% (HPLC)	254740-64-2	5MG	$83.31	2025-07-31	Buy
Sigma-Aldrich	SML2808	Sparsentan ≥98% (HPLC)	254740-64-2	25MG	$362	2025-07-31	Buy
TRC	R129300	RE201	254740-64-2	1mg	$165	2021-12-16	Buy
TRC	R129300	RE201	254740-64-2	10mg	$1320	2021-12-16	Buy
Medical Isotopes, Inc.	72248	RE201	254740-64-2	10mg	$2200	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML2808	5MG	$83.31	Buy
SML2808	25MG	$362	Buy
R129300	1mg	$165	Buy
R129300	10mg	$1320	Buy
72248	10mg	$2200	Buy

Sparsentan Chemical Properties,Uses,Production

Description

Sparsentan is an oral, dual endothelin angiotensin receptor antagonist that is being developed by Travere Therapeutics for the treatment of immunoglobulin A (IgA) nephropathy and focal segmental glomerulosclerosis (FSGS).^[1]

Uses

RE 201 is used an Endothelin A receptor antagonist used in the treatment of hypertension.

Definition

Sparsentan (RE-021) is a selective dual-acting receptor antagonist with affinity for endothelin (A type) and angiotensin II receptors (Type 1). Sparsentan combines the active moieties of the selective AT1 receptor antagonist irbesartan and a selective ETA receptor antagonist.

Biological Activity

Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.

Side effects

Common side effects of Sparsentan include swelling of the hands, legs, ankles and feet; dizziness; and low red blood cells (anaemia).
Serious side effects of Sparsentan include hives; difficulty breathing; swelling of the face, lips, tongue, or throat; nausea; vomiting; stomach pain (upper right side); tiredness; loss of appetite; yellowing of the skin or eyes (jaundice); dark urine; fever; itching; severe birth defects low blood pressure; dizziness; lightheadedness; fainting; muscle cramps; dry skin; shortness of breath; trouble sleeping; frequent urination; little or no urination; abnormal blood test results (increased potassium); unusual weight gain and swelling of the ankles or legs.

in vitro

Sparsentan dose dependently antagonizes the angiotensin II-induced pressor response with an ED50 value of 0.8 μmol/kg iv and 3.6 μmol/kg po. Sparsentan also shows efficacious and long acting in the big ET-1-induced pressor model. Sparsentan causes a significant lowering of blood pressure at the lowest dose tested (10 μmol/kg/day) in spontaneously hypertensive rats. Sparsentan shows good oral bioavailability in rats, dogs, and monkeys, averaging 40%, 86%, and 21% F, respectively. At 100 μmol/kg/day, Sparsentan reduces the blood pressure from 170 to less than 100 mmHg during the course of the drug’s pharmacokinetic duration. Sparsentan at 100 μmol/kg/day essentially converts the spontaneously hypertensive rats into normotensive rats during the course of its pharmacokinetic duration.

References

[1] Syed, Yahiya Y. “Sparsentan: First Approval.” Drugs 83 6 (2023): 563–568.

Sparsentan Preparation Products And Raw materials

Raw materials

Preparation Products

Sparsentan Suppliers

Global( 175)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.	+86-512-68780025 +8618962125825	sales@ryanchem.com	China	136	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368	sales@sjar-tech.com	China	504	58
Eaglech（shanghai）Pharmaceutical Co., Ltd	+86-2160290089 +86-13884467586	eagpharm@gmail.com	China	114	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13470	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Nanjing Shizhou Biotechnology Co., Ltd	+86-15850508050	sean.lv@synzest.com	China	323	58

Supplier	Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	58
Eaglech（shanghai）Pharmaceutical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Nanjing Shizhou Biotechnology Co., Ltd	58

Is sparsentan an FDA-approved drug?
The US Food and Drug Administration has granted full approval to Travere Therapeutics’ sparsentan (Filspari) for slowing kidne....
Jan 20，2025

View Lastest Price from Sparsentan manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-14	Sparsentan 254740-64-2	US $53.00-173.00 / mg		98.81%	10g	TargetMol Chemicals Inc.
2025-09-11	Sparsentan 254740-64-2	US $0.00 / g	1g	More Than 99%	100kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2024-09-19	Sparsentan 254740-64-2	US $0.00-0.00 / Gram	10Gram	99	5Tons	Chengdu Aupone Pharmaceutical Co.Ltd.

Sparsentan
254740-64-2
US $53.00-173.00 / mg
98.81%
TargetMol Chemicals Inc.

Sparsentan
254740-64-2
US $0.00 / g
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Sparsentan
254740-64-2
US $0.00-0.00 / Gram
99
Chengdu Aupone Pharmaceutical Co.Ltd.

254740-64-2(Sparsentan )Related Search:

Isobutylbenzene 2-Chloro-2-methylpropane 4-Methyl-2-pentanone

4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide Sparsentan (RE-021) Sparsentan-d5 (RE-021-d5) RE 201 [1,1'-Biphenyl]-2-sulfonamide, 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)- Sparsentan 4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide BMS-346567 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide formerly known as DARA PS433540 PS433540; RE-021; FORMERLY KNOWN AS DARA RE-021 Sparsentan(PS433540) 4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-... DARA-a Sparsentan,RE 021,Inhibitor,inhibit,Angiotensin Receptor,Endothelin Receptor,RE021 Sparentan Spashentan Sparsentan, 10 mM in DMSO Sparsentan (PS-433540, RE-021) Spasentan 254740-64-2 54740-64-2 C32H40N4O5S API