N-(4-Mesitylthiazol-2-yl)benzaMide
- CAS No.
- 1001753-24-7
- Chemical Name:
- N-(4-Mesitylthiazol-2-yl)benzaMide
- Synonyms
- INH6;INH-6; INH6;INH6, 10 mM in DMSO;N-(4-Mesitylthiazol-2-yl)benzaMide;Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6;Apoptosis,Inhibitor,INH 6,INH6,INH-6,inhibit;N-(4-Mesitylthiazol-2-yl)benzaMide USP/EP/BP;N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]benzamide;N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide;Benzamide, N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-
- CBNumber:
- CB12707933
- Molecular Formula:
- C19H18N2OS
- Molecular Weight:
- 322.42
- MDL Number:
- MFCD04722622
- MOL File:
- 1001753-24-7.mol
- MSDS File:
- SDS
| Melting point | 192-193 °C |
|---|---|
| Density | 1.216±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | ≥32.2 mg/mL in DMSO; insoluble in H2O; ≥3.55 mg/mL in EtOH with gentle warming and ultrasonic |
| form | Powder |
| pka | 7.07±0.70(Predicted) |
| color | White to off-white |
| CAS DataBase Reference | 1001753-24-7 |
| UNSPSC Code | 12352200 |
N-(4-Mesitylthiazol-2-yl)benzaMide price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 373271 | Hec1/Nek2MitoticPathwayInhibitorII,INH6-CAS1001753-24-7-Calbiochem TheHec1/Nek2MitoticPathwayInhibitorII,INH6,alsoreferencedunderCAS1001 | 1001753-24-7 | 10mg | $167 | 2023-06-20 | Buy |
| Cayman Chemical | 21772 | INH6 ≥98% | 1001753-24-7 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 21772 | INH6 ≥98% | 1001753-24-7 | 5mg | $76 | 2024-03-01 | Buy |
| Cayman Chemical | 21772 | INH6 ≥98% | 1001753-24-7 | 10mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 21772 | INH6 ≥98% | 1001753-24-7 | 25mg | $249 | 2024-03-01 | Buy |
N-(4-Mesitylthiazol-2-yl)benzaMide Chemical Properties,Uses,Production
Uses
INH6 is a Hec1 inhibitor that targets the Hec1/Nek2 pathway and causes chromosome mis-alignment as well as cell death.
Biological Activity
inh6 is a potent inhibitor of hec1/nek2 [1].hec1 is an oncogene that involved in spindle checkpoint signaling and is overexpressed in many human cancers. nek2 is a serine/threonine-protein kinase that phosphorylates hec1, which is critical for its mitotic function and cell survival [1].inh6 is a potent hec1/nek2 inhibitor. inh6 inhibited hec1/nek2 function through protein degradation that led to chromosome mis-segregation and cell death. in mda-mb468 and mda-mb231 human breast cancer cell lines, hela human cervical cancer line and k562 human erythromyeloblastoid leukemia cell line, inh6 exhibited significantly anti-proliferation activities with ic50 values of 2.1, 1.7, 2.4 and 2.5 μm, respectively. in hela cell extract, inh6-conjugated matrix selectively co-precipitated with cellular hec1, which suggested that inh6 bound to cellular hec1. in hela cells, inh6 (6.25 μm) reduced nek2 by 50% at 8-11 h. in addition, inh6 slightly reduced hec1 over time. also, inh6 increased mitotic population with multipolar spindle configurations. in hela cells expressing the chromosome marker protein h2b-gfp, inh6 increased chromosome misalignment. in hela cells, inh6 exhibited progressive morphological changes of dying cells and induced apoptosis by 20% [1].
target
Hec1/Nek2 complex
IC 50
NEK2
References
[1]. qiu xl, li g, wu g, et al. synthesis and biological evaluation of a series of novel inhibitor of nek2/hec1 analogues. j med chem, 2009, 52(6): 1757-1767.
N-(4-Mesitylthiazol-2-yl)benzaMide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22866 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5899 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 |
