3-Indoleacetamide
- CAS No.
- 879-37-8
- Chemical Name:
- 3-Indoleacetamide
- Synonyms
- INDOLE-3-ACETAMIDE;2-(1H-INDOL-3-YL)ACETAMIDE;INDOLEACETAMIDE;1H-Indole-3-acetamide;NSC 1969;BRN0873543;3-Indoleace;BRN 0873543;BRN-0873543;ACETAMIDOINDOZE
- CBNumber:
- CB1278653
- Molecular Formula:
- C10H10N2O
- Molecular Weight:
- 174.2
- MDL Number:
- MFCD00005641
- MOL File:
- 879-37-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Indole-3-acetamide 98% | 286281 | 1g | $58.2 |
| Indole-3-acetamide 98% | 286281 | 5g | $80.5 |
| Indole-3-acetamide >98.0%(HPLC)(N) | I0668 | 5g | $40 |
| Indole-3-acetamide >98.0%(HPLC)(N) | I0668 | 25g | $157 |
| Indole-3-acetamide | 34475 | 5G | $288 |
| More product size | |||
| Melting point | 148-150 °C(lit.) |
|---|---|
| Boiling point | 469.7±28.0 °C(Predicted) |
| Density | 1.285±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly) |
| pka | 16.37±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C10H10N2O/c11-10(13)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,12H,5H2,(H2,11,13) |
| InChIKey | ZOAMBXDOGPRZLP-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2)C(CC(N)=O)=C1 |
| CAS DataBase Reference | 879-37-8(CAS DataBase Reference) |
| FDA UNII | O9SEW65XW3 |
| NIST Chemistry Reference | 3-Indoleacetamide(879-37-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xi |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
3-Indoleacetamide price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 286281 | Indole-3-acetamide 98% | 879-37-8 | 1g | $58.2 | 2026-03-19 | Buy |
| Sigma-Aldrich | 286281 | Indole-3-acetamide 98% | 879-37-8 | 5g | $80.5 | 2026-03-19 | Buy |
| TCI Chemical | I0668 | Indole-3-acetamide >98.0%(HPLC)(N) | 879-37-8 | 5g | $40 | 2026-03-19 | Buy |
| TCI Chemical | I0668 | Indole-3-acetamide >98.0%(HPLC)(N) | 879-37-8 | 25g | $157 | 2026-03-19 | Buy |
| Medical Isotopes, Inc. | 34475 | Indole-3-acetamide | 879-37-8 | 5G | $288 | 2021-12-16 | Buy |
3-Indoleacetamide Chemical Properties,Uses,Production
Chemical Properties
White to Orange to Green powder to crystal
Uses
Indole-3-acetamide was used in the synthesis of [5.5.6.6]diazafenestrane skeleton and indole-3-acetic acid.
Reactant for the synthesis of:
PET agent for imaging of protein kinase C
A potential agent against Prion Disease
Protein kinase C (PKC) inhibitor bisindolylmaleimide IV
Glycogen synthase kinase-3 (GSK-3) inhibitors
Inhibitors of CaMKIId
A VEGF inhibitor
JAK3 inhibitors
Inhibitors of NAD+-Dependent Histone Deacetylases
Inhibitors of human adipocyte fatty acid-binding protein
Cyclin-dependent kinase inhibitors
Definition
ChEBI: Indole-3-acetamide is a member of the class of indoles that is acetamide substituted by a 1H-indol-3-yl group at position 2. It is an intermediate in the production of plant hormone indole acetic acid (IAA). It has a role as a fungal metabolite, a bacterial metabolite and a plant metabolite. It is a N-acylammonia, a monocarboxylic acid amide and a member of indoles. It is functionally related to an acetamide.
General Description
Indole-3-acetamide is an auxin precursor.
Biological Activity
Indole-3-acetamide is a biosynthesis intermediate of indole-3-acetic acid. Indole-3-acetic acid is the most common natural plant growth hormone of the auxin class.
Synthesis
771-51-7
879-37-8
The general procedure for the synthesis of 3-indoleacetamide from indole-3-acetonitrile was as follows: the reaction was carried out in a 100-mL stainless steel autoclave. Indole-3-acetonitrile (0.10 g, 1.00 mmol) was added to a mixture of ethylenediamine (0.12 g, 2.00 mmol), CoCl2-H2O (0.24 g, 1.00 mmol), and Zn (0.07 g, 1.00 mmol) and the mixture was transferred to the autoclave. For reactions to be performed in solvent, an additional 5 mL of solvent was added. The autoclave was pressurized to 5.00 atm using O2. the reaction mixture was stirred in a preheated 120°C oil bath for 12 hr. Upon completion of the reaction, the mixture was cooled to room temperature and the product was purified by silica gel column chromatography using a solvent mixture of n-hexane and CH2Cl2 (1:1) as eluent to give the final 3-indoleacetamide in 88% yield.
References
[1] Tetrahedron, 1989, vol. 45, # 5, p. 1347 - 1354
[2] Research on Chemical Intermediates, 2015, vol. 41, # 8, p. 5071 - 5078
[3] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980, vol. 16, # 5, p. 501 - 506
[4] Khimiya Geterotsiklicheskikh Soedinenii, 1980, # 5, p. 645 - 650
3-Indoleacetamide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2949 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2542 | 58 |
Related articles
- 3-Indoleacetamide: Conformational Analysis & Auxin Biosynthesis in Plants
- 3-Indoleacetamide shows high structural rigidity via rotational spectroscopy and is converted to auxin by specific hydrolases ....
- Feb 26，2026
View Lastest Price from 3-Indoleacetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | Indole-3-acetamide
879-37-8
|
US $31.00 / mg | 99.87% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | 3-Indoleacetamide
879-37-8
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-25 | Indole-3-acetamide
879-37-8
|
US $122.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- Indole-3-acetamide
879-37-8
- US $31.00 / mg
- 99.87%
- TargetMol Chemicals Inc.
-
- 3-Indoleacetamide
879-37-8
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Indole-3-acetamide
879-37-8
- US $122.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
