AG 825
- CAS No.
- 149092-50-2
- Chemical Name:
- AG 825
- Synonyms
- AG 825;Zinc02572484;TYRPHOSTIN C15;AG 825 USP/EP/BP;TYRPHOSTIN AG 825;AG-825, 10 mM in DMSO;AG 825, ErbB2 inhibitor;AG 825 (Tyrphostin AG 825);AG 825 - CAS 149092-50-2 - Calbiochem;4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE
- CBNumber:
- CB1283828
- Molecular Formula:
- C19H15N3O3S2
- Molecular Weight:
- 397.47
- MDL Number:
- MFCD01074971
- MOL File:
- 149092-50-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tyrphostin AG 825 ≥92.5% | T5443 | 2mg | $105.4 |
| AG 825 | 121765 | 2mg | $190 |
| AG-825 ≥98% | 10010243 | 1mg | $31 |
| AG-825 ≥98% | 10010243 | 5mg | $99 |
| AG-825 ≥98% | 10010243 | 10mg | $168 |
| storage temp. | −20°C |
|---|---|
| solubility | DMSO: soluble |
| form | Yellow solid |
| color | Light yellow to yellow |
| Sensitive | Light Sensitive |
| InChI | 1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+ |
| InChIKey | KXDONFLNGBQLTN-WUXMJOGZSA-N |
| SMILES | COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
AG 825 price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T5443 | Tyrphostin AG 825 ≥92.5% | 149092-50-2 | 2mg | $105.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | 121765 | AG 825 | 149092-50-2 | 2mg | $190 | 2026-04-30 | Buy |
| Cayman Chemical | 10010243 | AG-825 ≥98% | 149092-50-2 | 1mg | $31 | 2026-04-30 | Buy |
| Cayman Chemical | 10010243 | AG-825 ≥98% | 149092-50-2 | 5mg | $99 | 2026-04-30 | Buy |
| Cayman Chemical | 10010243 | AG-825 ≥98% | 149092-50-2 | 10mg | $168 | 2026-04-30 | Buy |
AG 825 Chemical Properties,Uses,Production
Uses
A selective ErbB2 inhibitor
Uses
AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer.
Definition
ChEBI: An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth factor receptor antagonist.
Biological Activity
Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
in vivo
AG-825 (20 mg/kg, i.p.) decreases peritoneal inflammation in Zymosan (HY-159069)-treated mice, and increases lung neutrophil apoptosis and macrophage efferocytosis in a murine acute lung injury model[4].
AG-825 (1 mg/kg, min-osmotic pump, 14 days) causes cardiac dilation and selective increase in β1AR density in mice[7].
| Animal Model: | Murine model of LPS induced acute lung inflammation[4] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Had no effect on percentage of, or absolute number of neutrophils or macrophages. Increased the percentage of neutrophil apoptosis. Elevated macrophage efferocytosis. |
| Animal Model: | Murine model of Zymosan (HY-159069)-induced peritonitis[4] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Did not induce leukopenia. Showed fewer inflammatory cells in peritoneal lavage. Reduced the neutrophil chemoattractant and proinflammatory cytokine, KC. Reduced IgM. |
IC 50
ErbB2: 0.35 μM (IC50); EGFR: 19 μM (IC50)
storage
Store at +4°C
AG 825 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 825 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10001 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Suzhou Chireach Biomedical Technology Co., Ltd. | 0512-65856968 | sales@chireach.com | China | 59 | 70 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9658 | 60 |
