3-CARBETHOXYUMBELIFERONE
- CAS No.
- 6093-71-6
- Chemical Name:
- 3-CARBETHOXYUMBELIFERONE
- Synonyms
- YZ9;AURORA 9226;AKOS BBS-00008132;YZ9, 10 mM in DMSO;YZ9, PFKFB3 inhibitor;3-CARBETHOXYUMBELIFERONE;ETHYL 3-UMBELLIFERYLCARBOXYLATE;ethyl umbelliferone-3-carboxylate;Ethyl 7-Hydroxycoumarin-3-carboxylate;Ethyl7-Hydroxycoumarin-3-carboxylate>
- CBNumber:
- CB1302710
- Molecular Formula:
- C12H10O5
- Molecular Weight:
- 234.2
- MDL Number:
- MFCD00017641
- MOL File:
- 6093-71-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 7-Hydroxycoumarin-3-carboxylic acid ethyl ester ≥98% (HPLC) | SML1270 | 10mg | $96.9 |
| Ethyl 7-Hydroxycoumarin-3-carboxylate >98.0%(GC) | E1017 | 200mg | $157 |
| YZ9 ≥98% | 15352 | 5mg | $32 |
| YZ9 ≥98% | 15352 | 10mg | $57 |
| YZ9 ≥98% | 15352 | 50mg | $139 |
| More product size | |||
| Melting point | 170.0 to 174.0 °C |
|---|---|
| Boiling point | 448.3±45.0 °C(Predicted) |
| Density | 1.397±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 7.32±0.20(Predicted) |
| form | powder |
| color | white to beige |
| λmax | 398nm(EtOH)(lit.) |
| CAS DataBase Reference | 6093-71-6 |
| FDA UNII | X538NC636R |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H227 |
| Precautionary statements | P501-P210-P280-P370+P378-P403+P235 |
| WGK Germany | 3 |
| HS Code | 29339900 |
3-CARBETHOXYUMBELIFERONE price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1270 | 7-Hydroxycoumarin-3-carboxylic acid ethyl ester ≥98% (HPLC) | 6093-71-6 | 10mg | $96.9 | 2025-07-31 | Buy |
| TCI Chemical | E1017 | Ethyl 7-Hydroxycoumarin-3-carboxylate >98.0%(GC) | 6093-71-6 | 200mg | $157 | 2025-07-31 | Buy |
| Cayman Chemical | 15352 | YZ9 ≥98% | 6093-71-6 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 15352 | YZ9 ≥98% | 6093-71-6 | 10mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 15352 | YZ9 ≥98% | 6093-71-6 | 50mg | $139 | 2024-03-01 | Buy |
3-CARBETHOXYUMBELIFERONE Chemical Properties,Uses,Production
Chemical Properties
Brown solid
Uses
Z9 is a potent inhibitor of PFKFB3, a member of 6-phosphofructo-2-kinases family. It avidly competes with fructose 6-phosphate (F6P) at PFKFB3. YZ9 is also cell permeable, inhibiting the growth of HeLa cells.
Biological Activity
YZ9 is a 5, 6, 7, 8-tetrahydroxy-2-(4-hydroxyphenyl) chromen-4-one (N4A) inhibitor.', 'YZ9 is a potent inhibitor of PFKFB3 (6-phosphfructo-2-kinase/fructose-2,6-bisphosphatase) with an IC50 = 183 nM. PFKFB3 is over expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YZ9 dose dependently inhibits proliferation of HeLa cells.
Synthesis
105-53-3
95-01-2
6093-71-6
The general procedure for the synthesis of ethyl 7-hydroxy-2-oxo-2H-benzopyran-3-carboxylate from 2,4-dihydroxybenzaldehyde (3.70 mmol) and diethyl malonate (7.90 mmol) was as follows: piperidine (10 drops) was added to a solution of diethyl malonate of 2,4-dihydroxybenzaldehyde and the resulting mixture was stirred and reacted for 2 hours at room temperature. Upon completion of the reaction, the reaction mixture was acidified with 10% aqueous hydrochloric acid solution (5 mL). The precipitated solid was collected by filtration and washed with cold water (10 mL). The crude product was purified by fast column chromatography using dichloromethane:ethyl acetate (70:30, v/v) as eluent to afford the target compound ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate (0.735 g, 97% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100 MHz, DMSO-d6): 1H NMR δ 1.28 (t, J = 7.1 Hz, 3H), 4.24 (q, J = 7.1 Hz, 2H), 6.71 (d, J = 1.8 Hz, 1H), 6.83 (dd, J = 1.8, 8.3 Hz, 1H), 7.74 (d, J = 8.3 Hz, 1H), 8.66 (s, 1H), 11.07 (s, 1H); 13C NMR δ 14.1, 60.8, 101.7, 110.4, 113.9, 120.0, 132.1, 149.4, 156.3, 157.0, 162.9, 164.0.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 22, p. 2715 - 2718
[2] Patent: KR101744655, 2017, B1. Location in patent: Paragraph 0058-0060
[3] Patent: CN106279125, 2017, A. Location in patent: Paragraph 0039; 0040
[4] Letters in Organic Chemistry, 2013, vol. 10, # 7, p. 468 - 477
[5] Chemical Communications, 2017, vol. 53, # 11, p. 1813 - 1816
3-CARBETHOXYUMBELIFERONE Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| Jiangxi Lotchem Co.,Ltd. | +8615270827708 | lancetu@jxlotchem.com | CHINA | 338 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32436 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20284 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Hebei Fengmu Trading Co., Ltd. | +8613393234347 | Lyla@fengmuchem.com | China | 2943 | 58 |
View Lastest Price from 3-CARBETHOXYUMBELIFERONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-09 | YZ9
6093-71-6
|
US $50.00 / mg | 99.13% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-11-18 | 3-CARBETHOXYUMBELIFERONE
6093-71-6
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-12-20 | 3-CARBETHOXYUMBELIFERONE
6093-71-6
|
US $1.00 / KG | 1KG | 99% | KG/T | Career Henan Chemical Co |
-
- YZ9
6093-71-6
- US $50.00 / mg
- 99.13%
- TargetMol Chemicals Inc.
-
- 3-CARBETHOXYUMBELIFERONE
6093-71-6
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 3-CARBETHOXYUMBELIFERONE
6093-71-6
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
