ARV-825
- CAS No.
- 1818885-28-7
- Chemical Name:
- ARV-825
- Synonyms
- AVR-825;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-;CS-2252;ARV-825;ARV-825 ，S8297;ARV-825;ARV 825;ARV825;ARV-825, 10 mM in DMSO;Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825;2-[(S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]acetamide;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide
- CBNumber:
- CB13041384
- Molecular Formula:
- C46H47ClN8O9S
- Molecular Weight:
- 923.43
- MDL Number:
- MFCD29472237
- MOL File:
- 1818885-28-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.47±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C(protect from light) |
| solubility |
DMSO:5.0(Max Conc. mg/mL);5.41(Max Conc. mM) DMF:5.0(Max Conc. mg/mL);5.41(Max Conc. mM) Water:0.0(Max Conc. mg/mL);0.0(Max Conc. mM) |
| form | A crystalline solid |
| pka | 10.74±0.40(Predicted) |
| color | Light yellow to yellow |
| InChIKey | RWLOGRLTDKDANT-TYIYNAFKSA-N |
| SMILES | ClC1=CC=C(C2=N[C@@H](CC(NC3=CC=C(C=C3)OCCOCCOCCOCCNC4=C(C5=CC=C4)C(N(C5=O)C6C(NC(CC6)=O)=O)=O)=O)C7=NN=C(C)N7C8=C2C(C)=C(C)S8)C=C1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| WGK Germany | WGK 3 |
|---|---|
| HS Code | 2933998090 |
| Storage Class | 11 - Combustible Solids |
ARV-825 price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3423 | ARV-825 ≥98% (HPLC) | 1818885-28-7 | 5MG | $117 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3423 | ARV-825 ≥98% (HPLC) | 1818885-28-7 | 25MG | $469 | 2026-04-30 | Buy |
| Cayman Chemical | 21109 | ARV-825 ≥98% | 1818885-28-7 | 500μg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 21109 | ARV-825 ≥98% | 1818885-28-7 | 1mg | $102 | 2026-04-30 | Buy |
| Cayman Chemical | 21109 | ARV-825 ≥98% | 1818885-28-7 | 5mg | $444 | 2026-04-30 | Buy |
ARV-825 Chemical Properties,Uses,Production
Description
ARV-825 is a PROTAC molecule composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4.
Uses
ARV-825 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively.
Biological Activity
ARV-825 is a BRD4 inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, causing rapid, efficient and sustained degradation of BRD4 protein and sustained downregulation of MYC levels.
in vivo
In the mouse model transplanted with human leukemia cells, the leukemia burden of the mice in the ARV-825 experimental group was significantly lower than that in the control group, and their survival time was also longer than that in the control group.
target
| Target | Value |
| BRD4 BD2 (Cell-free assay) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 28 nM(Kd)|
| BRD4 BD1 (Cell-free assay) | 90 nM(Kd) |
References
[1] Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22(6):755-63. DOI:10.1016/j.chembiol.2015.05.009
ARV-825 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1875 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
View Lastest Price from ARV-825 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | ARV-825
1818885-28-7
|
1mg | 98%min | 500mg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-05-11 | ARV-825
1818885-28-7
|
$60.00-178.00 | 97.60% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-14 | ARV-825
1818885-28-7
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
